Molecular regulation of neural crest development.

abstract：:Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...

journal_title：Molecular neurobiology

authors： Chen M,Puschmann TB,Marasek P,Inagaki M,Pekna M,Wilhelmsson U,Pekny M

更新日期：2018-07-01 00:00:00

abstract：:The discovery of α-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by α-synuclein accumulation. In fact, as compared with pre-α-synuclein times, a "new" PD can now be described as a whole-body disease in which a progre...

journal_title：Molecular neurobiology

authors： Ulusoy A,Di Monte DA

更新日期：2013-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases (PARPs) are enzymes that catalyze the transfer of ADP-ribose units from β-nicotinamide adenine dinucleotide (NAD(+)) to acceptor proteins. PARP-1 is responsible for more than 90 % of protein poly-ADP-ribosylation in the brain and may play a role as a molecular switch for cell survival and ...

journal_title：Molecular neurobiology

authors： Banasik M,Stedeford T,Strosznajder RP

更新日期：2012-08-01 00:00:00

abstract：:Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). Legumain, a lysosomal cysteine protease, plays an important role in neuroinflammation during ischemic stroke and depressive disorder. Legumain is involved in AD process through cleaving APP; however, it is unclear if legumain can poss...

journal_title：Molecular neurobiology

authors： Chen R,Zhang Q,Yan Y,Zhang Y,Zhang T

更新日期：2020-11-21 00:00:00

abstract：:The gammaretroviral human endogenous retrovirus (HERV) families MRSV/HERV-W and HERV-H (including the closely related HERV-Fc1) are associated with an increased risk of multiple sclerosis (MS). Complete HERV sequences betray their endogenous retroviral origin, with open reading frames in gag, pro, pol and env being fl...

journal_title：Molecular neurobiology

authors： Morris G,Maes M,Murdjeva M,Puri BK

更新日期：2019-04-01 00:00:00

abstract：:In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depres...

journal_title：Molecular neurobiology

authors： Aydin E,Hritcu L,Dogan G,Hayta S,Bagci E

更新日期：2016-11-01 00:00:00

abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...

journal_title：Molecular neurobiology

authors： Johnson AM,Sugo E,Barreto D,Hiew CC,Lawson JA,Connolly AM,Somerville E,Hasic E,Bye AM,Cunningham AM

更新日期：2016-10-01 00:00:00

abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...

journal_title：Molecular neurobiology

authors： Lunardi N,Oklopcic A,Prillaman M,Erisir A,Jevtovic-Todorovic V

更新日期：2015-10-01 00:00:00

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is enriched in membrane phospholipids of the central nervous system (CNS) and has a role in aging and neuropsychiatric disorders. DHA is metabolized by the enzyme Alox15 to 17S-hydroxy-DHA, which is then converted to 7S-hydroperoxy,17S-hydroxy-DHA by a 5-lipoxygenase, and thence via epoxy in...

journal_title：Molecular neurobiology

authors： Shalini SM,Ho CF,Ng YK,Tong JX,Ong ES,Herr DR,Dawe GS,Ong WY

更新日期：2018-02-01 00:00:00

abstract：:We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...

journal_title：Molecular neurobiology

authors： Ahn SM,Kim YR,Shin YI,Ha KT,Lee SY,Shin HK,Choi BT

更新日期：2019-01-01 00:00:00

abstract：:Neurodegenerative foldopathies are characterized by aberrant folding of diseased modified proteins, which are major constituents of the intracellular and extracellular lesions. These lesions correlate with the cognitive and/or motor impairment seen in these diseases. The majority of the disease modified proteins in ne...

journal_title：Molecular neurobiology

authors： Jadhav S,Zilka N,Novak M

更新日期：2013-12-01 00:00:00

abstract：:Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...

journal_title：Molecular neurobiology

authors： Montenegro-Burke JR,Woldstad CJ,Fang M,Bade AN,McMillan J,Edagwa B,Boska MD,Gendelman HE,Siuzdak G

更新日期：2019-04-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Hyperpalatable diets (HP) impair brain metabolism, and regular physical exercise has an apparent opposite effect. Here, we combined a prior long-term exposure to HP diet followed by physical exercise and evaluated the impact on some neuroenergetic components and on cognitive performance. We assessed the extracellular ...

journal_title：Molecular neurobiology

authors： Portela LV,Brochier AW,Haas CB,de Carvalho AK,Gnoato JA,Zimmer ER,Kalinine E,Pellerin L,Muller AP

更新日期：2017-10-01 00:00:00

abstract：:Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...

journal_title：Molecular neurobiology

authors： Lu G,Chang JT,Liu Z,Chen Y,Li M,Zhu JJ

更新日期：2016-11-01 00:00:00

abstract：:α-Lipoic acid-plus (LAP), an amine derivative of α-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron. However, the application of LAP in experimental subarachnoid hemorrhage (SAH) is still not well known. This study was designed to evaluate the potential neuroprotection...

journal_title：Molecular neurobiology

authors： Wang Y,Gao A,Xu X,Dang B,You W,Li H,Yu Z,Chen G

更新日期：2015-08-01 00:00:00

abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...

journal_title：Molecular neurobiology

authors： Lu AQ,Barnstable CJ

更新日期：2019-09-01 00:00:00

abstract：:The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...

journal_title：Molecular neurobiology

authors： Lee MJ,Jang M,Choi J,Lee G,Min HJ,Chung WS,Kim JI,Jee Y,Chae Y,Kim SH,Lee SJ,Cho IH

更新日期：2016-04-01 00:00:00

abstract：:Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...

journal_title：Molecular neurobiology

authors： Shin T,Ahn M,Moon C,Kim S,Sim KB

更新日期：2013-06-01 00:00:00

abstract：:The characteristic functions of tissues and organs result from the integrated activity of individual cells. Nowhere is this more evident than in the nervous system, where the activities of single neurons communicating via electrical and chemical signals mediate complex functions, such as learning and memory. The past ...

journal_title：Molecular neurobiology

authors： O'Dowd DK,Smith MA

更新日期：1996-12-01 00:00:00

abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...

journal_title：Molecular neurobiology

authors： Wang H,Gao N,Li Z,Yang Z,Zhang T

更新日期：2016-04-01 00:00:00

abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...

journal_title：Molecular neurobiology

authors： da Encarnação TG,Portugal CC,Nogueira CE,Santiago FN,Socodato R,Paes-de-Carvalho R

更新日期：2018-10-01 00:00:00

abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...

journal_title：Molecular neurobiology

authors： Boghdadi AG,Teo L,Bourne JA

更新日期：2018-03-01 00:00:00

abstract：:Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide association and other genetic studies have implicated at least 500+ genes associated with the occurrence of autism spectrum disorders (ASD) including the human semaphorin 3F (Sema 3F) and neuropilin 2 (NRP2) genes. However, the geneti...

journal_title：Molecular neurobiology

authors： Li Z,Jagadapillai R,Gozal E,Barnes G

更新日期：2019-08-01 00:00:00

abstract：:Neural stem cells (NSCs) are hitherto regarded as perspective candidates for cell transplantation in clinical therapies for multilevel spinal cord injury and function restoration. However, the extreme drawbacks of NSCs available for injury transplantation still represent a significant bottleneck in neural regeneration...

journal_title：Molecular neurobiology

authors： Yang H,Liu C,Chen B,An J,Zhang R,Zhang Q,Zhao J,He B,Hao DJ

更新日期：2017-01-01 00:00:00

abstract：:The identification of causative mutations in the (pro)granulin gene (GRN) has been a major breakthrough in the research on frontotemporal dementia (FTD). So far, all FTD-associated GRN mutations are leading to neurodegeneration through a "loss-of-function" mechanism, encouraging researchers to develop a growing number...

journal_title：Molecular neurobiology

authors： Kleinberger G,Capell A,Haass C,Van Broeckhoven C

更新日期：2013-02-01 00:00:00

abstract：:The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-β peptide (Aβ) in the form of amyloid plaques and neuronal loss. Neural stem cell (NSC) is being scrutinized as a promising cell replacement therapy for various neurodegenerative diseases. However, the unfavorable...

journal_title：Molecular neurobiology

authors： Cui GH,Shao SJ,Yang JJ,Liu JR,Guo HD

更新日期：2016-03-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in st...

journal_title：Molecular neurobiology

authors： Jiang S,Deng C,Lv J,Fan C,Hu W,Di S,Yan X,Ma Z,Liang Z,Yang Y

更新日期：2017-03-01 00:00:00

abstract：:Methylmercury (MeHg) is an extremely dangerous environmental pollutant that induces severe toxic effects in the central nervous system. Neuronal damage plays critical roles mediating MeHg-induced loss of brain function and neurotoxicity. The molecular mechanisms of MeHg neurotoxicity are incompletely understood. The o...

journal_title：Molecular neurobiology

authors： Liu W,Xu Z,Yang T,Xu B,Deng Y,Feng S

更新日期：2017-09-01 00:00:00