Abstract:
:In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depressive responses were studied by means of the elevated plus-maze and forced swimming tests. The scopolamine alone-treated rats exhibited the following: decrease of the spontaneous alternation percentage in Y-maze test, increase of the number of working and reference memory errors in radial arm-maze test, along with decrease of the exploratory activity, the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and decrease of swimming time and increase of immobility time within forced swimming test. Inhalation of the P. peregrina essential oil significantly improved memory formation and exhibited anxiolytic- and antidepressant-like effects in scopolamine-treated rats. Our results suggest that the P. peregrina essential oil inhalation ameliorates scopolamine-induced memory impairment, anxiety, and depression. Moreover, studies on the P. peregrina essential oil may open a new therapeutic window for the prevention of neurological abnormalities closely related to Alzheimer's disease.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Aydin E,Hritcu L,Dogan G,Hayta S,Bagci Edoi
10.1007/s12035-016-9693-9subject
Has Abstractpub_date
2016-11-01 00:00:00pages
6557-6567issue
9eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9693-9journal_volume
53pub_type
杂志文章abstract::The neurotoxicity of levodopa (L-DOPA) on neural stem cells (NSCs) and treatment strategies to protect NSCs from this neurotoxicity remain to be elucidated. Recently, an active form of vitamin D3 has been reported to display neuroprotective properties. Therefore, we investigated the protective effect of 1,25-dyhydroxy...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8835-1
更新日期:2015-04-01 00:00:00
abstract::Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9203-5
更新日期:2016-07-01 00:00:00
abstract::Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxi...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8304-7
更新日期:2012-08-01 00:00:00
abstract::Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9701-0
更新日期:2017-03-01 00:00:00
abstract::Recently, deregulated microRNA (miRNA) expression contributes to the development and progression of human glioblastoma. The aim of the present study was to evaluate the level of miR-154 and Wnt5a in glioblastoma tissues and cells. We further investigated the molecular mechanisms of miR-154 and Wnt5a in glioblastoma ce...
journal_title:Molecular neurobiology
pub_type: 杂志文章,收录出版
doi:10.1007/s12035-016-9867-5
更新日期:2017-05-01 00:00:00
abstract::Pharmacoresistance in epilepsy is a major challenge to successful clinical therapy. Glucocorticoid receptor (GR) dysregulation can affect the underlying disease pathogenesis. We recently reported that local drug biotransformation at the blood-brain barrier is upregulated by GR, which controls drug-metabolizing enzymes...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02043-9
更新日期:2020-11-01 00:00:00
abstract::Methylmercury (MeHg) is an extremely dangerous environmental pollutant that induces severe toxic effects in the central nervous system. Neuronal damage plays critical roles mediating MeHg-induced loss of brain function and neurotoxicity. The molecular mechanisms of MeHg neurotoxicity are incompletely understood. The o...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0020-2
更新日期:2017-09-01 00:00:00
abstract::Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12035-017-0414-9
更新日期:2018-02-01 00:00:00
abstract::Brain injuries such as trauma and stroke lead to glial scar formation by reactive astrocytes which produce and secret axonal outgrowth inhibitors. Chondroitin sulfate proteoglycans (CSPG) constitute a well-known class of extracellular matrix molecules produced at the glial scar and cause growth cone collapse. The CSPG...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0565-8
更新日期:2018-04-01 00:00:00
abstract::CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-9787-4
更新日期:2017-04-01 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-0978-z
更新日期:2018-11-01 00:00:00
abstract::Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0240-5
更新日期:2017-11-01 00:00:00
abstract::Alpha synuclein (α-synuclein) is a neuronal protein found predominately in presynaptic terminals. While the pathological effect of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention has been placed on changes in monomeric α-synuclein and related physiologic...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02123-w
更新日期:2021-01-01 00:00:00
abstract::Alzheimer's disease (AD), a neurodegenerative disorder exhibiting a gradual decline in cognitive function, is characterized by the presence of neuritic plaques composed of neurofibrillary tangles and amyloid-β (Aβ) peptide. Available drugs for AD therapy have small effect sizes and do not alter disease progression. Se...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8401-2
更新日期:2013-06-01 00:00:00
abstract::Since the discovery of leptin and the central melanocortin circuit, electrophysiological studies have played a major role in elucidating mechanisms underlying energy homeostasis. This review highlights the contribution of findings made by electrophysiological measurements to the current understanding of hypothalamic n...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8241-5
更新日期:2012-04-01 00:00:00
abstract::Oxidative damage to the inner ear is responsible for several types of sensorineural deafness. Cochlear stria marginal cells (MCs) are thought to be vulnerable to such oxidative stress. Activated poly(ADP-ribose) polymerase 1 (PARP1) has been implicated in several diseases, but the effect of PARP1 on MCs subjected to o...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9469-7
更新日期:2016-11-01 00:00:00
abstract::Accumulating evidence demonstrated that GABAergic dysfunction contributes to the pathogenesis of Alzheimer's disease (AD). The GABA aminotransferase (ABAT) gene encodes a mitochondrial GABA transaminase and plays key roles in the biogenesis and metabolism of gamma-aminobutyric acid (GABA), which is a major inhibitory ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02271-z
更新日期:2021-01-06 00:00:00
abstract::Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-015-9423-8
更新日期:2016-10-01 00:00:00
abstract::Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8847-x
更新日期:2015-08-01 00:00:00
abstract::The development of in vitro amplification systems allows detecting femtomolar amounts of prion protein scrapie (PrP(Sc)) in human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects of prion disease type, codon 129 genotype, PrP(Sc) type, and other disease-related factors on the real-time quak...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8709-6
更新日期:2015-02-01 00:00:00
abstract::Despite the increasing evidence of eye abnormalities, the effects of prenatal exposure to cocaine on the visual system are still poorly understood. This study was aimed at analyzing the qualitative and quantitative organization of the retinal photoreceptor cells (PR) and outer nuclear layer (ONL) after prenatal exposu...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02740686
更新日期:1995-08-01 00:00:00
abstract::Parkinson's disease and other synucleinopathies are characterized by the presence of intra-neuronal protein aggregates enriched in the presynaptic protein α-synuclein. α-synuclein is considered an intrinsically disordered 14 kDa monomer, and although poorly understood, its transition to higher-order multimeric species...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0266-8
更新日期:2017-12-01 00:00:00
abstract::The original version of this article unfortunately contained mistake in its Funding inforation. ...
journal_title:Molecular neurobiology
pub_type: 已发布勘误
doi:10.1007/s12035-018-1095-8
更新日期:2018-10-01 00:00:00
abstract::The loss of dopaminergic (DA) neurons in the substantia nigra (SN) is a major feature in the pathology of Parkinson's disease (PD). Using neural stem or progenitor cells (NSC/NPCs), the prospect of replacing the missing or damaged DA neurons is very attractive for PD therapy. However, little is known about the endogen...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1005-0
更新日期:2018-11-01 00:00:00
abstract::Tissue acidosis is a common feature in many pathological conditions. Activation of acid-sensing ion channel 1a (ASIC1a) plays a key role in acidosis-mediated neurotoxicity. Protein kinase C (PKC) activity has been proved to be associated with many physiological processes and pathological conditions; however, whether P...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02056-4
更新日期:2020-11-01 00:00:00
abstract::Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1263-x
更新日期:2019-04-01 00:00:00
abstract::Abnormal hippocampal neurogenesis is a prominent feature of temporal lobe epilepsy (TLE) models, which is thought to contribute to abnormal brain activity. Stromal cell-derived factor-1 (SDF-1) and its specific receptor CXCR4 play important roles in adult neurogenesis. We investigated whether treatment with the CXCR4 ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9102-9
更新日期:2016-04-01 00:00:00
abstract::Metabolic defects are common pathological phenomena following traumatic brain injury (TBI) which contribute to poor prognosis. Brain-derived neurotrophic factor (BDNF) is an important regulator of neuronal survival, development, function, and plasticity. This study was designed to investigate the potential effects of ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0576-5
更新日期:2018-04-01 00:00:00
abstract::Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1625-z
更新日期:2019-11-01 00:00:00
abstract::Myeloperoxidase (MPO) has paradoxically been found to be able to both activate matrix metalloproteinases (MMPs) as well as inhibit MMPs. However, these regulatory effects have not yet been observed in vivo, and it is unclear which pathway is relevant in vivo. We aim to track MPO regulation of MMP activity in living an...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1137-2
更新日期:2019-02-01 00:00:00