CXCR4 Antagonist AMD3100 Suppresses the Long-Term Abnormal Structural Changes of Newborn Neurons in the Intraventricular Kainic Acid Model of Epilepsy.

abstract：:Prion diseases are transmissible neurodegenerative disorders of humans and animals, which are characterized by the aggregation of abnormal prion protein (PrPSc) in the central nervous system. Although several small compounds that bind to normal PrP (PrPC) have been shown to inhibit structural conversion of the protein...

journal_title：Molecular neurobiology

authors： Miyazaki Y,Ishikawa T,Kamatari YO,Nakagaki T,Takatsuki H,Ishibashi D,Kuwata K,Nishida N,Atarashi R

更新日期：2019-01-01 00:00:00

abstract：:Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...

journal_title：Molecular neurobiology

authors： Breydo L,Morgan D,Uversky VN

更新日期：2016-04-01 00:00:00

abstract：:Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible stu...

journal_title：Molecular neurobiology

authors： Lv S,Dai C,Liu Y,Shi R,Tang Z,Han M,Bian R,Sun B,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...

journal_title：Molecular neurobiology

authors： Schlief ML,Gitlin JD

更新日期：2006-04-01 00:00:00

abstract：:For the epigenetic characterization of neuromyelitis optica (NMO), we determined whether messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in subjects with and without NMO. lncRNA and mRNA expression profiles of NMO patients and healthy controls were generated by using microarray an...

journal_title：Molecular neurobiology

authors： Xu J,Zhang F,Gao C,Ma X,Peng X,Kong D,Hao J

更新日期：2017-04-01 00:00:00

abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...

journal_title：Molecular neurobiology

authors： Wang H,Gao N,Li Z,Yang Z,Zhang T

更新日期：2016-04-01 00:00:00

abstract：:The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...

journal_title：Molecular neurobiology

authors： Zhang J,Shipston MJ,Brown SB

更新日期：2010-08-01 00:00:00

abstract：:Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mech...

journal_title：Molecular neurobiology

authors： Neves LMS,Gonçalves ECD,Cavalli J,Vieira G,Laurindo LR,Simões RR,Coelho IS,Santos ARS,Marcolino AM,Cola M,Dutra RC

更新日期：2018-07-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental cha...

journal_title：Molecular neurobiology

authors： Odorcyk FK,Ribeiro RT,Roginski AC,Duran-Carabali LE,Couto-Pereira NS,Dalmaz C,Wajner M,Netto CA

更新日期：2021-01-08 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is a novel physiological therapy that has been adopted to clinically treat psychiatric disorders. Our previous study indicated the potential therapeutic effect of rTMS on posttraumatic stress disorder (PTSD). However, the exact molecular mechanism is elusive. Current...

journal_title：Molecular neurobiology

authors： Liu G,Feng D,Wang J,Zhang H,Peng Z,Cai M,Yang J,Zhang R,Wang H,Wu S,Tan Q

更新日期：2018-05-01 00:00:00

abstract：:Cerebrolysin is a peptide mixture able to ameliorate symptomatology and delay progression of neurological disorders such as Alzheimer's disease and dementia. The administration of this drug in humans presents several criticisms due to its short half-life, poor stability, and high doses needed to achieve the effect. Th...

journal_title：Molecular neurobiology

authors： Ruozi B,Belletti D,Sharma HS,Sharma A,Muresanu DF,Mössler H,Forni F,Vandelli MA,Tosi G

更新日期：2015-10-01 00:00:00

abstract：:The chronic stage multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), remains refractory to current treatments. This refractory nature may be due to the fact that current treatments are primarily immunomodulatory, which prevent further demyelination but lack the capacity...

journal_title：Molecular neurobiology

authors： Li X,Zhang Y,Yan Y,Ciric B,Ma CG,Chin J,Curtis M,Rostami A,Zhang GX

更新日期：2017-08-01 00:00:00

abstract：:Several plant-derived natural compounds are known to exhibit anti-amyloid aggregation activity which makes them attractive as potential therapies to treat Alzheimer's disease. The mechanisms of their anti-amyloid activity are not well known. In this regard, many natural compounds are known to exhibit direct binding to...

journal_title：Molecular neurobiology

authors： Bu XL,Rao PPN,Wang YJ

更新日期：2016-08-01 00:00:00

abstract：:Tissue acidosis is a common feature in many pathological conditions. Activation of acid-sensing ion channel 1a (ASIC1a) plays a key role in acidosis-mediated neurotoxicity. Protein kinase C (PKC) activity has been proved to be associated with many physiological processes and pathological conditions; however, whether P...

journal_title：Molecular neurobiology

authors： Zhang L,Leng TD,Yang T,Li J,Xiong ZG

更新日期：2020-11-01 00:00:00

abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...

journal_title：Molecular neurobiology

authors： Ustyugov A,Shevtsova E,Bachurin S

更新日期：2015-10-01 00:00:00

abstract：:A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...

journal_title：Molecular neurobiology

authors： Cieślik M,Czapski GA,Wójtowicz S,Wieczorek I,Wencel PL,Strosznajder RP,Jaber V,Lukiw WJ,Strosznajder JB

更新日期：2020-03-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the applicatio...

journal_title：Molecular neurobiology

authors： Lu YM,Gao YP,Tao RR,Liao MH,Huang JY,Wu G,Han F,Li XM

更新日期：2016-05-01 00:00:00

abstract：:In this study, we investigated the influence of elevated RAS expression on the growth of meningioma in vivo and in vitro. The IOMM-LEE cells, representing a cell line derived from malignant meningioma, were divided into blank control group (cells without any drug treatment), negative control group (cells treated with ...

journal_title：Molecular neurobiology

authors： Jiang C,Song T,Li J,Ao F,Gong X,Lu Y,Zhang C,Chen L,Liu Y,He H,Huang O

更新日期：2017-01-01 00:00:00

abstract：:Extracellular nucleotides, particularly adenosine 5'-triphosphate (ATP), act as signaling molecules in the inner ear. Roles as neurotransmitters, neuromodulators, and as autocrine or paracrine humoral factors are evident. The diversity of the signaling pathways for nucleotides, which include a variety of ATP-gated ion...

journal_title：Molecular neurobiology

authors： Housley GD

更新日期：1998-02-01 00:00:00

abstract：:The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrPC). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein (PrPSc), levels of mature endogenous Sho become reduced. To study the regulatory effect of the proteostati...

journal_title：Molecular neurobiology

authors： Kang SG,Mays CE,Daude N,Yang J,Kar S,Westaway D

更新日期：2019-11-01 00:00:00

abstract：:Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...

journal_title：Molecular neurobiology

authors： Wang J,Yu JT,Tan L

更新日期：2015-04-01 00:00:00

abstract：:We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed ...

journal_title：Molecular neurobiology

authors： Lopez JR,Uryash A,Kolster J,Estève E,Zhang R,Adams JA

更新日期：2018-11-01 00:00:00

abstract：:The development of technologies for high-resolution nucleic acid localization in cells and tissues has contributed significantly to our understanding of transcriptional and translational regulation in eukaryotic cells. These methods include nonisotopic in situ hybridization methods for light and electron microscopy, a...

journal_title：Molecular neurobiology

authors： Martone ME,Pollock JA,Ellisman MH

更新日期：1998-12-01 00:00:00

abstract：:Early-onset familial Alzheimer's disease (AD) is most commonly associated with the mutations in presenilin-1 (PS1). PS1 is the catalytic component of the γ-secretase complex, which cleaves amyloid precursor protein to produce amyloid-β (Aβ), the major cause of AD. Presenilin enhancer 2 (Pen2) is critical for activatin...

journal_title：Molecular neurobiology

authors： Chen WT,Hsieh YF,Huang YJ,Lin CC,Lin YT,Liu YC,Lien CC,Cheng IH

更新日期：2015-12-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of brain-derived neurotrophic factor (BDNF)-transfected bone marrow mesenchymal stem cells (BMSCs) on neural functional recovery and synaptophysin expression in rats with cerebral infarction (CI). A total of 120 healthy Sprague Dawley rats were randomly divided ...

journal_title：Molecular neurobiology

authors： Zhang Y,Qiu B,Wang J,Yao Y,Wang C,Liu J

更新日期：2017-07-01 00:00:00

abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

journal_title：Molecular neurobiology

authors： Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

更新日期：2020-11-01 00:00:00

abstract：:Ischemic stroke, caused by obstruction of blood flow to the brain, would initiate microglia activation which contributes to neuronal damage. Therefore, inhibition of microglia-mediated neuroinflammation could be a therapeutic strategy for ischemic stroke. This study was aimed to elucidate the anti-inflammatory effects...

journal_title：Molecular neurobiology

authors： Wu MH,Huang CC,Chio CC,Tsai KJ,Chang CP,Lin NK,Lin MT

更新日期：2016-09-01 00:00:00

abstract：:α-Lipoic acid-plus (LAP), an amine derivative of α-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron. However, the application of LAP in experimental subarachnoid hemorrhage (SAH) is still not well known. This study was designed to evaluate the potential neuroprotection...

journal_title：Molecular neurobiology

authors： Wang Y,Gao A,Xu X,Dang B,You W,Li H,Yu Z,Chen G

更新日期：2015-08-01 00:00:00

abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...

journal_title：Molecular neurobiology

authors： Alvarez-Ricartes N,Oliveros-Matus P,Mendoza C,Perez-Urrutia N,Echeverria F,Iarkov A,Barreto GE,Echeverria V

更新日期：2018-10-01 00:00:00