Subcellular localization of mRNA in neuronal cells. Contributions of high-resolution in situ hybridization techniques.

abstract：:Extracellular nucleotides, particularly adenosine 5'-triphosphate (ATP), act as signaling molecules in the inner ear. Roles as neurotransmitters, neuromodulators, and as autocrine or paracrine humoral factors are evident. The diversity of the signaling pathways for nucleotides, which include a variety of ATP-gated ion...

journal_title：Molecular neurobiology

authors： Housley GD

更新日期：1998-02-01 00:00:00

abstract：:Cyclin-dependent kinases (Cdks) play a key role in orchestrating the coordination of cell cycle progression in proliferating cells. The escape from the proper control of the cell cycle by the upregulation of cyclins or aberrant activation of Cdks leads to malignant transformation. In quiescent cells and/or terminally ...

journal_title：Molecular neurobiology

authors： Schmid G,Strosznajder JB,Wesierska-Gadek J

更新日期：2006-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease characterized by degeneration of upper and lower motor neurons (MNs), generalized weakness and muscle atrophy. The "neurocentric" view of ALS assumes that the disease primarily affects motor neurons, while muscle alterations only...

journal_title：Molecular neurobiology

authors： Pansarasa O,Rossi D,Berardinelli A,Cereda C

更新日期：2014-04-01 00:00:00

abstract：:α-Synuclein aggregation contributes to the Parkinson's disease (PD) pathology in multiple ways-the two most important being the activation of neuroinflammation and mitochondrial dysfunction. Our recent studies have shown the beneficial effects of a heat shock protein (HSP) inducer, carbenoxolone (Cbx), in reducing the...

journal_title：Molecular neurobiology

authors： Thakur P,Nehru B

更新日期：2015-02-01 00:00:00

abstract：:Amyloid-β oligomers (AβOs) toxicity causes mitochondrial dysfunction, leading to synaptic failure in Alzheimer's disease (AD). Considering presynaptic high energy demand and tight Ca2+ regulation, impairment of mitochondrial function can lead to deteriorated neural activity and cell death. In this study, an AD mouse m...

journal_title：Molecular neurobiology

authors： da Silva JS,Nonose Y,Rohden F,Lukasewicz Ferreira PC,Fontella FU,Rocha A,Brochier AW,Apel RV,de Lima TM,Seminotti B,Amaral AU,Galina A,Souza DO

更新日期：2020-11-01 00:00:00

abstract：:Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the endoplasmic reticulum of all cells. All three RyR isoforms, RyR1-3, are expressed in the brain, with RyR2 predominating. RyRs are localized within the soma, axons, dendritic spines, and presynaptic terminals of neurons. RyRs are highly ...

journal_title：Molecular neurobiology

authors： Abu-Omar N,Das J,Szeto V,Feng ZP

更新日期：2018-02-01 00:00:00

abstract：:There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...

journal_title：Molecular neurobiology

authors： Rivera DS,Lindsay CB,Codocedo JF,Carreño LE,Cabrera D,Arrese MA,Vio CP,Bozinovic F,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...

journal_title：Molecular neurobiology

authors： Liou CJ,Yang CM,Lee TH,Liu PS,Hsieh HL

更新日期：2019-01-01 00:00:00

abstract：:The goal of this study was to evaluate if the immunohistochemical expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death, determining the possible use of sympathetic thoracic ganglia from subjects after brain death as study group. The third left ...

journal_title：Molecular neurobiology

authors： de Moura Júnior NB,das-Neves-Pereira JC,de Campos JR,de Oliveira FR,Wolosker N,Parra ER,Capelozzi VL,Jatene FB

更新日期：2012-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...

journal_title：Molecular neurobiology

authors： Xiang Q,Bi R,Xu M,Zhang DF,Tan L,Zhang C,Fang Y,Yao YG

更新日期：2017-09-01 00:00:00

abstract：:Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the BK channel are enriched at the presynaptic nerve terminal, where CaMKII associates with synaptic vesicles whereas the BK channel colocalizes with voltage-sensitive Ca(2+) channels in the plasma membrane. Mounting evidence suggests that these two proteins p...

journal_title：Molecular neurobiology

authors： Wang ZW

更新日期：2008-10-01 00:00:00

abstract：:α-Synuclein (α-syn) has been recognized to induce neuroinflammation and to disturb nerve repair process in Parkinson's disease. However, the potential mechanisms underlying α-syn-induced impairment of adult neurogenesis remain unclear. In the present study, A53T mutant α--synuclein transgenic (A53Ttg/tg) mice, caspase...

journal_title：Molecular neurobiology

authors： Fan Z,Lu M,Qiao C,Zhou Y,Ding JH,Hu G

更新日期：2016-12-01 00:00:00

abstract：:The considerable roles of transcription factors, and the associated signaling molecules that activate them, are well deciphered in the context of various biological processes. One of the important transcription factors, the transforming growth factor-β (TGF-β) pathway, has a profound role in neuronal cell survival-a p...

journal_title：Molecular neurobiology

authors： Haque R,Nazir A

更新日期：2016-01-01 00:00:00

abstract：:Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible stu...

journal_title：Molecular neurobiology

authors： Lv S,Dai C,Liu Y,Shi R,Tang Z,Han M,Bian R,Sun B,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Late-onset Alzheimer's disease (LOAD) is a high-occurrence neurological disorder but the difficulty in identifying precise and early biomarkers has complicated the understanding of the disease and the development of new treatments. In this sense, important knowledge is emerging regarding novel molecular and biological...

journal_title：Molecular neurobiology

authors： Herrera-Espejo S,Santos-Zorrozua B,Álvarez-González P,Lopez-Lopez E,Garcia-Orad Á

更新日期：2019-12-01 00:00:00

abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...

journal_title：Molecular neurobiology

authors： da Encarnação TG,Portugal CC,Nogueira CE,Santiago FN,Socodato R,Paes-de-Carvalho R

更新日期：2018-10-01 00:00:00

abstract：:Addiction is a chronic psychiatric disease which represents a global problem, and stress can increase drug addiction and relapse. Taking into account frequent concomitance of nicotine dependence and stress, the purpose of the present study was to assess behavioral and biochemical effects of chronic unpredictable mild ...

journal_title：Molecular neurobiology

authors： Biala G,Pekala K,Boguszewska-Czubara A,Michalak A,Kruk-Slomka M,Grot K,Budzynska B

更新日期：2018-04-01 00:00:00

abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...

journal_title：Molecular neurobiology

authors： Fonseca AC,Moreira PI,Oliveira CR,Cardoso SM,Pinton P,Pereira CF

更新日期：2015-04-01 00:00:00

abstract：:(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...

journal_title：Molecular neurobiology

authors： Zhang JC,Xu H,Yuan Y,Chen JY,Zhang YJ,Lin Y,Yuan SY

更新日期：2017-07-01 00:00:00

abstract：:YKL-40 is the most highly expressed gene in glioblastoma compared with normal brain tissues. Previous studies assessing the association between YKL-40 and survival in glioblastoma patients reported varying magnitude of estimates. The objective of this meta-analysis was to determine the prognostic value of YKL-40 in gl...

journal_title：Molecular neurobiology

authors： Qin G,Li X,Chen Z,Liao G,Su Y,Chen Y,Zhang W

更新日期：2017-07-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...

journal_title：Molecular neurobiology

authors： Sunwoo JS,Lee ST,Im W,Lee M,Byun JI,Jung KH,Park KI,Jung KY,Lee SK,Chu K,Kim M

更新日期：2017-03-01 00:00:00

abstract：:An increasing number of circulating micro-ribonucleic acids (microRNAs, miRNAs) have been discovered its potential as biomarkers to diagnose neurodegenerative diseases (NDs) by many researchers. However, there were obvious inconsistencies among previous studies, and thus we performed this meta-analysis to evaluate whe...

journal_title：Molecular neurobiology

authors： Zi Y,Yin Z,Xiao W,Liu X,Gao Z,Jiao L,Deng L

更新日期：2015-12-01 00:00:00

abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...

journal_title：Molecular neurobiology

authors： Murphy M,Bartlett PF

更新日期：1993-07-01 00:00:00

abstract：:There is robust evidence that major depression (MDD) is accompanied by a low-grade activation of the immune-inflammatory response system, which is involved in the pathophysiology of this disorder. It is also becoming apparent that glia cells are in reciprocal communication with neurons, orchestrate various neuromodula...

journal_title：Molecular neurobiology

authors： Rudzki L,Maes M

更新日期：2020-10-01 00:00:00

abstract：:A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...

journal_title：Molecular neurobiology

authors： Zhang QQ,Jiang T,Gu LZ,Zhu XC,Zhao HD,Gao Q,Zhu HQ,Zhou JS,Zhang YD

更新日期：2016-11-01 00:00:00

abstract：:Statins have proven their effectiveness in the treatment of cardiovascular disease. This class of drugs has also attracted attention as a potential treatment for dissimilar diseases such as certain types of cancers and neurodegenerative diseases. What appears to be a contradiction is that, in the case of cancer, it ha...

journal_title：Molecular neurobiology

authors： Wood WG,Igbavboa U,Muller WE,Eckert GP

更新日期：2013-10-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation channels that form the predominant excitatory neurotransmitter receptors on muscles and nerves in the peripheral nervous system. AChRs are also expressed on neurons in lower amounts throughout the central nervous system. AChRs are eve...

journal_title：Molecular neurobiology

authors： Lindstrom J

更新日期：1997-10-01 00:00:00

abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...

journal_title：Molecular neurobiology

authors： Velasco G,Carracedo A,Blázquez C,Lorente M,Aguado T,Haro A,Sánchez C,Galve-Roperh I,Guzmán M

更新日期：2007-08-01 00:00:00

abstract：:Hypertension is one of the co-morbid conditions for stroke and profoundly increases its incidence. Angiotensin II (AngII) is shown to be at the center stage in driving the renin angiotensin system via activation of angiotensin 1 receptor (AT1R). This makes the AT1R gene one of the candidates whose differential regulat...

journal_title：Molecular neurobiology

authors： Jain S,Tulsulkar J,Rana A,Kumar A,Shah ZA

更新日期：2016-04-01 00:00:00

abstract：:Males are predominantly affected by autism spectrum disorders (ASD) with a prevalence ratio of 5:1. However, the underlying pathological mechanisms governing the male preponderance of ASD remain unclear. Recent studies suggested that epigenetic aberrations may cause synaptic dysfunctions, which might be related to the...

journal_title：Molecular neurobiology

authors： Kim KC,Choi CS,Kim JW,Han SH,Cheong JH,Ryu JH,Shin CY

更新日期：2016-01-01 00:00:00