Abstract:
:Late-onset Alzheimer's disease (LOAD) is a high-occurrence neurological disorder but the difficulty in identifying precise and early biomarkers has complicated the understanding of the disease and the development of new treatments. In this sense, important knowledge is emerging regarding novel molecular and biological candidates with diagnostic potential, including microRNAs (miRNAs), which have a key role in gene repression. The aim of this systematic review was to define the role of miRNAs' expression as biomarkers for LOAD both in brain tissues, which could help understand the biology of the disease, and circulating tissues, which could serve as non-invasive markers of the pathology. A systematic search was performed in Web of Science and PubMed using the keywords ((Alzheimer or Alzheimer's) and (microRNA or microRNAs or miRNA or miRNAs or miR)) until August 2018 to retrieve all articles that presented independent original data evaluating the impact of miRNA expression on the development of LOAD in human population. A total of 90 studies investigating the role of miRNAs' expression in the development of LOAD were identified. While other widely studied miRNAs such as hsa-miR-146a presented contradictory results among studies, deregulation in brain tissue of seven miRNAs, hsa-miR-16-5p, hsa-miR-34a-5p, hsa-miR-107, hsa-miR-125-5p, hsa-miR-132-3p, hsa-miR-181-3p, and hsa-miR-212-3p, was consistently identified in LOAD patients. Their role in the disease could be mediated through the regulation of key pathways, such as axon guidance, longevity, insulin, and MAPK signaling pathway. However, regarding their role as non-invasive biomarkers of LOAD in fluids, although the limited results available are promising, further studies are required.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Herrera-Espejo S,Santos-Zorrozua B,Álvarez-González P,Lopez-Lopez E,Garcia-Orad Ádoi
10.1007/s12035-019-01676-9subject
Has Abstractpub_date
2019-12-01 00:00:00pages
8376-8391issue
12eissn
0893-7648issn
1559-1182pii
10.1007/s12035-019-01676-9journal_volume
56pub_type
杂志文章abstract::The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1596-0
更新日期:2019-11-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...
journal_title:Molecular neurobiology
pub_type: 已发布勘误
doi:10.1007/s12035-018-0949-4
更新日期:2018-06-01 00:00:00
abstract::Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0759-0
更新日期:2018-07-01 00:00:00
abstract::Maternal separation (MS) causes long-lasting epigenetic changes in the brain and increases vulnerability to traumatic events in adulthood. Of interest, there may be sex-specific differences in these epigenetic changes. In this study, the extent of histone acetylation in the hippocampus (HIP) and the expression of BDNF...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02224-6
更新日期:2020-11-27 00:00:00
abstract::Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0144-4
更新日期:2017-10-01 00:00:00
abstract::Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析
doi:10.1007/s12035-016-9823-4
更新日期:2017-05-01 00:00:00
abstract::Extracellular nucleotides, particularly adenosine 5'-triphosphate (ATP), act as signaling molecules in the inner ear. Roles as neurotransmitters, neuromodulators, and as autocrine or paracrine humoral factors are evident. The diversity of the signaling pathways for nucleotides, which include a variety of ATP-gated ion...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740601
更新日期:1998-02-01 00:00:00
abstract::Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9465-y
更新日期:2016-10-01 00:00:00
abstract::Polyglutamine [poly(Q)] disorders are a class of trinucleotide repeat expansion neurodegenerative disorders which are dominantly inherited and progressively acquired with age. This group of disorders entail the characteristic formation of protein aggregates leading to widespread loss of neurons in different regions of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1160-3
更新日期:2019-02-01 00:00:00
abstract::Dodecafluoropentane emulsion (DDFPe) in 250 nm nanodroplets seems to swell modestly to accept and carry large amounts of oxygen in the body at >29 °C. Small particle size allows oxygen delivery even into hypoxic tissue unreachable by erythrocytes. Using permanent cerebral embolic occlusion in rabbits, we assessed DDFP...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8495-6
更新日期:2013-10-01 00:00:00
abstract::There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0969-0
更新日期:2018-12-01 00:00:00
abstract::Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02112-z
更新日期:2021-01-01 00:00:00
abstract::Structural rearrangements of chromosome 10 are frequently observed in glioblastoma multiforme and over 80 % of tumour samples archived in the catalogue of somatic mutations in cancer database had gene copy number loss for PI4K2A which encodes phosphatidylinositol 4-kinase type IIalpha. PI4K2A loss of heterozygosity mi...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9034-9
更新日期:2016-01-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Her...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9717-5
更新日期:2017-03-01 00:00:00
abstract::Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1273-8
更新日期:2019-04-01 00:00:00
abstract::Atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8925-0
更新日期:2015-12-01 00:00:00
abstract::Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by intelligence decline, behavioral disorders and cognitive disability. The purpose of this study was to investigate gene expression in AD, based on published microarray data on Tg2576 mice. Hierarchical Cluster Analysis and Gene Ontol...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8384-4
更新日期:2013-06-01 00:00:00
abstract::Hypoxia, the major cause of ischemic injury, leads to debilitating disease in infants via birth asphyxia and cerebral palsy, whereas in adults via heart attack and stroke. A widespread, natural protective phenomenon termed 'hypoxic preconditioning' (PH) occurs when prior exposures to hypoxia eventually result in robus...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02091-1
更新日期:2020-12-01 00:00:00
abstract::Myeloperoxidase (MPO) has paradoxically been found to be able to both activate matrix metalloproteinases (MMPs) as well as inhibit MMPs. However, these regulatory effects have not yet been observed in vivo, and it is unclear which pathway is relevant in vivo. We aim to track MPO regulation of MMP activity in living an...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1137-2
更新日期:2019-02-01 00:00:00
abstract::Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0695-z
更新日期:2018-06-01 00:00:00
abstract::Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a severe deficiency in the activity of the branched-chain α-keto acid dehydrogenase complex, leading to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine. Infections have a significant role in precipitating ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8618-0
更新日期:2014-10-01 00:00:00
abstract::Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0240-5
更新日期:2017-11-01 00:00:00
abstract::The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935639
更新日期:1993-07-01 00:00:00
abstract::The endocannabinoid system (ECS) actively participates in several physiological processes within the central nervous system. Among such, its involvement in the downregulation of the N-methyl-D-aspartate receptor (NMDAr) through a modulatory input at the cannabinoid receptors (CBr) has been established. After its produ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1129-2
更新日期:2019-02-01 00:00:00
abstract::Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0524-4
更新日期:2018-03-01 00:00:00
abstract::α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in Parkinson's disease (PD). The aggregation of α-synuclein is believed to be a critical event in the disease process. α-Synuclein is characterized by a remarkable conformational plasticity, adopting different conforma...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-8818-2
更新日期:2015-01-01 00:00:00
abstract::While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0832-8
更新日期:2018-07-01 00:00:00
abstract::Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9903-5
更新日期:2017-07-01 00:00:00
abstract::Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-010-8121-9
更新日期:2010-06-01 00:00:00
abstract::Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-020-02066-2
更新日期:2020-11-01 00:00:00