Abstract：
:Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Herein, we hypothesized that pramipexole (PPX), a dopamine D2/D3 receptor-preferring agonist commonly used to treat Parkinson's disease (PD), would be a suitable therapeutic drug for EAE. Thus, we report the effects and the underlying mechanisms of action of PPX in the prevention of EAE. PPX (0.1 and 1 mg/kg) was administered intraperitoneally (i.p.) from day 0 to 40 post-immunization (p.i.). Our results showed that PPX 1 mg/kg prevented EAE development, abolishing EAE signs by blocking neuroinflammatory response, demyelination, and astroglial activation in spinal cord. Moreover, PPX inhibited the production of inflammatory cytokines, such as IL-17, IL-1β, and TNF-α in peripheral lymphoid tissue. PPX was also able to restore basal levels of a number of EAE-induced effects in spinal cord and striatum, such as reactive oxygen species, glutathione peroxidase, parkin, and α-synuclein (α-syn). Thus, our findings highlight the usefulness of PPX in preventing EAE-induced motor symptoms, possibly by modulating immune cell responses, such as those found in MS and other T helper cell-mediated inflammatory diseases.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Lieberknecht V,Junqueira SC,Cunha MP,Barbosa TA,de Souza LF,Coelho IS,Santos AR,Rodrigues AL,Dafré AL,Dutra RCdoi
10.1007/s12035-016-9717-5subject
Has Abstractpub_date
2017-03-01 00:00:00pages
1033-1045issue
2eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9717-5journal_volume
54pub_type
杂志文章abstract：:Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In t...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9740-6
更新日期：2017-03-01 00:00:00
abstract：:We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02816114
更新日期：1994-08-01 00:00:00
abstract：:The discovery of α-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by α-synuclein accumulation. In fact, as compared with pre-α-synuclein times, a "new" PD can now be described as a whole-body disease in which a progre...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8329-y
更新日期：2013-04-01 00:00:00
abstract：:OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy, chaperone activity, and apoptosis. Few studies on the role of OMI/HTRA2 in Alzheimer's disease (AD) are available, but none on its relationship with the cholinergi...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1383-3
更新日期：2019-07-01 00:00:00
abstract：:Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0524-4
更新日期：2018-03-01 00:00:00
abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-0947-6
更新日期：2018-10-01 00:00:00
abstract：:Hyperpalatable diets (HP) impair brain metabolism, and regular physical exercise has an apparent opposite effect. Here, we combined a prior long-term exposure to HP diet followed by physical exercise and evaluated the impact on some neuroenergetic components and on cognitive performance. We assessed the extracellular ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0119-5
更新日期：2017-10-01 00:00:00
abstract：:Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02935552
更新日期：1991-01-01 00:00:00
abstract：:Olfactory perception and learning play a vital role in the animal's entire life for habituation and survival. Insulin and insulin receptor signaling is well known to modulate the olfactory function and is also involved in the regulation of neurogenesis. A very high density of insulin receptors is present in the olfact...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02185-w
更新日期：2020-10-29 00:00:00
abstract：:Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a regulator of MMP-9 expression and cells migration. However, the mechanisms underlying thrombin-induced MMP-9 expression in rat brain astrocytes (RBA-1 cel...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8450-6
更新日期：2013-12-01 00:00:00
abstract：:Enriched environment (EE) protects the retina from adult rats against ischemia/reperfusion (I/R) injury; however, how the components of EE contribute to the recovery after retinal ischemic damage remains unclear. We analyzed the contribution of social, cognitive, and visual stimulation on functional and histological a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01715-5
更新日期：2020-01-01 00:00:00
abstract：:Males are predominantly affected by autism spectrum disorders (ASD) with a prevalence ratio of 5:1. However, the underlying pathological mechanisms governing the male preponderance of ASD remain unclear. Recent studies suggested that epigenetic aberrations may cause synaptic dysfunctions, which might be related to the...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8987-z
更新日期：2016-01-01 00:00:00
abstract：:Pharmacoresistance in epilepsy is a major challenge to successful clinical therapy. Glucocorticoid receptor (GR) dysregulation can affect the underlying disease pathogenesis. We recently reported that local drug biotransformation at the blood-brain barrier is upregulated by GR, which controls drug-metabolizing enzymes...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02043-9
更新日期：2020-11-01 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson's disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathwa...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0681-5
更新日期：2018-06-01 00:00:00
abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02108-9
更新日期：2021-01-01 00:00:00
abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved with neurotransmitter release. Wit...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8887-2
更新日期：2015-08-01 00:00:00
abstract：:Astrocytes comprise the major cell type in the central nervous system (CNS) and they are essential for support of neuronal functions by providing nutrients and regulating cell-to-cell communication. Astrocytes also are immune-like cells that become reactive in response to neuronal injury. Phospholipases A2 (PLA2) are ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:31:1-3:027
更新日期：2005-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative brain pathology and the most common form of dementia. Evidence suggests that extracellular vesicles (EVs) containing cytokines and microRNA are involved in inflammation regulation. The current study aimed to explore a potential impact of AD patients' EVs on d...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02013-1
更新日期：2020-10-01 00:00:00
abstract：:The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD) remain largely unclear. In the present study, we were aimed to identify the potential key molecules involved in spatial memory impairment in a triple transgenic (3xTg-AD) mouse model of AD. By employing two-dimensional fluorescence di...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9959-2
更新日期：2017-07-01 00:00:00
abstract：:The effects and mechanism of action of oligodeoxyribonucleotides containing CpG motif (CpG-ODNs) on neuron cells are largely unexamined. Here, we found that CpG-A ODNs but not other types of CpG-ODNs induced neurite retraction and cell apoptosis of rat embryonic neurons in a TLR9-independent manner. These effects of C...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8275-8
更新日期：2012-06-01 00:00:00
abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9465-y
更新日期：2016-10-01 00:00:00
abstract：:Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9203-5
更新日期：2016-07-01 00:00:00
abstract：:Neurons are highly polarized cells displaying an elaborate architectural morphology. The design of their dendritic arborization and the distribution of their synapses contribute importantly to information processing in the brain. The growth and complexity of dendritic arbors are driven by the formation of synapses alo...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1378-0
更新日期：2019-07-01 00:00:00
abstract：:Several studies support a protective effect of vitamin D on multiple sclerosis and experimental allergic encephalomyelitis (EAE), but the mechanisms of these favorable effects are unclear. Our study demonstrates that sphingosine 1-phosphate (S1P) is upregulated in the serum and spinal cords of EAE rats, but that vitam...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8686-9
更新日期：2014-12-01 00:00:00
abstract：:Astroglial scaring and limited neurogenesis are two problematic issues in recovery of spinal cord injury (SCI). In the meantime, it seems that mechanical manipulations of scaffold to inhibit astroglial scarring and improve neurogenesis is worthy of value. In the present investigation, the effect of nanofiber (gel) con...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9836-z
更新日期：2017-05-01 00:00:00
abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9249-4
更新日期：2015-10-01 00:00:00
abstract：:Neurodegenerative foldopathies are characterized by aberrant folding of diseased modified proteins, which are major constituents of the intracellular and extracellular lesions. These lesions correlate with the cognitive and/or motor impairment seen in these diseases. The majority of the disease modified proteins in ne...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8440-8
更新日期：2013-12-01 00:00:00
abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1583-5
更新日期：2019-10-01 00:00:00
abstract：:Lysine-specific demethylase 1 (LSD1/KDM1A) plays an important role in complex cellular processes such as differentiation, proliferation, apoptosis, and cell cycle progression. It has recently been demonstrated that during development, downregulation of LSD1 inhibits cell proliferation, modulates the expression of cell...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9206-2
更新日期：2016-05-01 00:00:00
abstract：:Stroke is the leading cause of severe disability, and lacunar stroke is related to cognitive decline and hemiparesis. There is no effective treatment for the majority of patients with stroke. Thus, stem cell-based regenerative medicine has drawn a growing body of attention due to the capabilities for trophic factor ex...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9530-6
更新日期：2016-11-01 00:00:00
