Abstract:
:Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In this study, we explore the transplantation of exogenous neural stem cells (NSCs) as the potential therapy for the photothrombotic ischemia stroke in a Kunming mice model. After stroke, mice receiving NSC transplantation demonstrated a better recovery of brain function during the neurobehavioral tests. Histology analysis of the brain samples from NSC transplanted mice demonstrated a reduction of brain damage caused by stroke. Moreover, immunofluorescence assay for biomarkers in brain sections confirmed that transplanted NSCs indeed differentiated to neurons and astrocytes, consistent with the improved brain function after stroke. Taken together, our data suggested that exogenous NSC transplantation could be a promising therapy for stroke.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Hou B,Ma J,Guo X,Ju F,Gao J,Wang D,Liu J,Li X,Zhang S,Ren Hdoi
10.1007/s12035-016-9740-6subject
Has Abstractpub_date
2017-03-01 00:00:00pages
1254-1262issue
2eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9740-6journal_volume
54pub_type
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