Abstract:
:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are intracellularly degraded by fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Thus, the function of ECS might be modulated in a direct way, through CB receptor ligands or indirectly by FAAH and MAGL inhibitors. We evaluated that the direct influence of ECS, using FAAH (URB 597) and MAGL (JZL 184) inhibitors, on the schizophrenia-like effects in mice. The behavioral schizophrenia-like symptoms were obtained in animals by using N-methyl D-aspartate (NMDA) receptor antagonists, MK-801. An acute administration of MK-801 (0.3 and 0.6 mg/kg) induced psychotic symptoms in rodents, manifested as the increase in locomotor activity, measured in actimeters, as well as the memory impairment, assessed in the passive avoidance (PA) task. We revealed that an acute administration of URB 597, at the dose of 0.3 mg/kg, attenuated MK-801 (0.6 mg/kg)-induced memory impairment. In turn, an acute administration of URB 597 at a higher dose (1 mg/kg) potentiated MK-801 (0.3 mg/kg)-induced memory impairment. Similarly, an acute administration of JZL 184 (20 and 40 mg/kg) intensified an amnestic effect of MK-801 (0.3 mg/kg). Moreover, an acute injection of JZL 184 (1 mg/kg) potentiated hyperlocomotion is provoked by MK-801 (0.3 and 0.6 mg/kg) administration. The present findings clearly indicate that ECS, through an indirect manner, modulates a variety of schizophrenia-like responses in mice.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Kruk-Slomka M,Banaszkiewicz I,Slomka T,Biala Gdoi
10.1007/s12035-019-1596-0subject
Has Abstractpub_date
2019-11-01 00:00:00pages
7251-7266issue
11eissn
0893-7648issn
1559-1182pii
10.1007/s12035-019-1596-0journal_volume
56pub_type
杂志文章abstract::Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9203-5
更新日期:2016-07-01 00:00:00
abstract::The effects and mechanism of action of oligodeoxyribonucleotides containing CpG motif (CpG-ODNs) on neuron cells are largely unexamined. Here, we found that CpG-A ODNs but not other types of CpG-ODNs induced neurite retraction and cell apoptosis of rat embryonic neurons in a TLR9-independent manner. These effects of C...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8275-8
更新日期:2012-06-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF), which belongs to transforming growth factor β superfamily, plays important roles in glioma pathogenesis. Gdnf mRNA is aberrantly increased in glioma cells, but the underlying transcription mechanism is unclear. Here, we found that although the base sequence in the pr...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8443-5
更新日期:2013-12-01 00:00:00
abstract::Chronic hyperammonemia impairs spatial memory by altering membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus. Intracerebral administration of extracellular cGMP to hyperammonemic rats restores spatial memory and membrane expression of AMPA receptors. The underlying molecular mechanisms re...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1387-z
更新日期:2019-06-01 00:00:00
abstract::Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-9029-6
更新日期:2016-01-01 00:00:00
abstract::Recently, deregulated microRNA (miRNA) expression contributes to the development and progression of human glioblastoma. The aim of the present study was to evaluate the level of miR-154 and Wnt5a in glioblastoma tissues and cells. We further investigated the molecular mechanisms of miR-154 and Wnt5a in glioblastoma ce...
journal_title:Molecular neurobiology
pub_type: 杂志文章,收录出版
doi:10.1007/s12035-016-9867-5
更新日期:2017-05-01 00:00:00
abstract::The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:34:3:163
更新日期:2006-12-01 00:00:00
abstract::We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1067-z
更新日期:2019-01-01 00:00:00
abstract::The epidermal growth factor (EGF) family of polypeptides is regulators for tissue development and repair, and is characterized by the fact that their mature forms are proteolytically derived from their integral membrane precursors. This article reviews roles of the prominent members of the EGF family (EGF, transformin...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02742440
更新日期:1999-10-01 00:00:00
abstract::Hippocampus-dependent memories, such as social recognition (SRM), are modulated by neurogenesis. However, the precise role of newborn neurons in social memory processing is still unknown. We showed previously that 1 week of enriched environment (EE) is sufficient to increase neurogenesis in the hippocampus (HIP) and t...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9922-2
更新日期:2017-07-01 00:00:00
abstract::Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:27:3:239
更新日期:2003-06-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...
journal_title:Molecular neurobiology
pub_type: 已发布勘误
doi:10.1007/s12035-018-0949-4
更新日期:2018-06-01 00:00:00
abstract::Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-013-8398-6
更新日期:2013-06-01 00:00:00
abstract::Ginsenoside Rg1 is efficient to prevent or treat mental disorders. However, the mechanisms underlying the effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD) are still not known. In this study, single-prolonged stress (SPS) regime, as well as injection of lipopolysaccharide (LPS), was used to produce P...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02213-9
更新日期:2020-11-19 00:00:00
abstract::Depression is a common non-motor symptom in patients with Parkinson's disease (PD) and difficult to treat. Crocin is a natural multipotential neuroprotective compound that has been shown to elicit antidepressant activity and is promising for the therapy of neuropsychological diseases. Here, we investigated the therape...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01941-2
更新日期:2020-07-01 00:00:00
abstract::Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasop...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02741376
更新日期:1999-02-01 00:00:00
abstract::Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740620
更新日期:1997-02-01 00:00:00
abstract::Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1424-y
更新日期:2019-07-01 00:00:00
abstract::Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01897-3
更新日期:2020-06-01 00:00:00
abstract::Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiesce...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-020-01958-7
更新日期:2020-07-01 00:00:00
abstract::Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anx...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8383-5
更新日期:2013-06-01 00:00:00
abstract::Evidence indicates that adverse experiences in early life may be a factor for immune disturbances leading to the depression in adulthood. Recently, a pivotal role in the pathogenesis of depression has been assigned to the activation of the brain Nod-like receptor pyrin-containing 3 (NLRP3) inflammasome. We investigate...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1458-1
更新日期:2019-08-01 00:00:00
abstract::A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...
journal_title:Molecular neurobiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12035-015-9261-8
更新日期:2016-05-01 00:00:00
abstract::Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular aspects that precede or accompany the deposit of β-amyloid in senile plaques attract attention, such as calcium dysregulation and neuroinflammation. It has been suggested that the Ca2+/calmodulin-dependent protein phosphatase, calcin...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01718-2
更新日期:2020-01-01 00:00:00
abstract::Glioblastoma (GBM) is a highly aggressive brain cancer with the worst prognosis of any central nervous system disease despite intensive multimodal therapy. Inevitably, glioblastoma is fatal, with recurrence of treatment-resistant tumour growth at distal sites leading to an extremely low median survival rate of 12-15 m...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-013-8464-0
更新日期:2013-12-01 00:00:00
abstract::Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9214-2
更新日期:2016-05-01 00:00:00
abstract::Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK pathways that in turn i...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0361-x
更新日期:2018-02-01 00:00:00
abstract::In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-01869-7
更新日期:2020-05-01 00:00:00
abstract::The understanding of how pain is processed at each stage in the peripheral and central nervous system is the precondition to develop new therapies for the selective treatment of pain. In the periphery, ATP can be released from various cells as a consequence of tissue injury or visceral distension and may stimulate the...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-007-0033-y
更新日期:2007-10-01 00:00:00
abstract::Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-010-8121-9
更新日期:2010-06-01 00:00:00