Abstract:
:Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the cell cycle length, and the fraction of cells that exit the cell cycle to become quiescent or differentiate. The underlying processes are tightly controlled and modulated by cyclin-dependent kinases (Cdks) and their interactions with cyclins and Cdk inhibitors (CKIs). Studies performed in the nervous system with mouse models lacking individual Cdks, cyclins, and CKIs, or combinations thereof, have shown that many of these molecules control proliferation rates in a cell-type specific and time-dependent manner. In this review, we will provide an update on the in vivo studies on cyclins, Cdks, and CKIs in neuronal and glial tissue. The goal is to highlight their impact on proliferation processes during the development of the peripheral and central nervous system, including and comparing normal and pathological conditions in the adult.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Grison A,Atanasoski Sdoi
10.1007/s12035-020-01958-7subject
Has Abstractpub_date
2020-07-01 00:00:00pages
3206-3218issue
7eissn
0893-7648issn
1559-1182pii
10.1007/s12035-020-01958-7journal_volume
57pub_type
杂志文章,评审abstract::Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH,...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9242-y
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journal_title:Molecular neurobiology
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9013-1
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journal_title:Molecular neurobiology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-9833-2
更新日期:2017-05-01 00:00:00
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journal_title:Molecular neurobiology
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pub_type: 杂志文章,评审
doi:10.1007/s12035-010-8121-9
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02165-0
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pub_type: 杂志文章
doi:10.1007/s12035-016-0361-x
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pub_type: 杂志文章
doi:10.1007/s12035-019-01701-x
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02816122
更新日期:1994-08-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1005-0
更新日期:2018-11-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1340-1
更新日期:2019-06-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1444-7
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02740620
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journal_title:Molecular neurobiology
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doi:10.1007/s12035-015-9093-6
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1514-5
更新日期:2019-09-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9796-3
更新日期:2017-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1307-2
更新日期:2019-05-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 已发布勘误
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更新日期:2018-06-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00