Abstract：
:Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK pathways that in turn induce cofilin phosphorylation and prevent depolymerization of actin filaments. Here, using a potent LIMK inhibitor (BMS-5), we investigated the role of LIMK activity in the dorsal hippocampus during contextual fear memory in rats. We first found that post-training administration of BMS-5 impaired memory consolidation in a dose-dependent manner. Inhibiting LIMK before training also disrupted memory acquisition. We then demonstrated that hippocampal LIMK activity seems to be critical for memory retrieval and reconsolidation, since both processes were impaired by BMS-5 treatment. Contextual fear memory extinction, however, was not sensitive to the same treatment. In conclusion, our findings demonstrate that hippocampal LIMK activity plays an important role in memory acquisition, consolidation, retrieval, and reconsolidation during contextual fear conditioning.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Lunardi P,Sachser RM,Sierra RO,Pedraza LK,Medina C,de la Fuente V,Romano A,Quillfeldt JA,de Oliveira Alvares Ldoi
10.1007/s12035-016-0361-xsubject
Has Abstractpub_date
2018-02-01 00:00:00pages
958-967issue
2eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-0361-xjournal_volume
55pub_type
杂志文章abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9935-x
更新日期：2017-07-01 00:00:00
abstract：:Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8398-6
更新日期：2013-06-01 00:00:00
abstract：:The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0857-z
更新日期：2018-08-01 00:00:00
abstract：:In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depres...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9693-9
更新日期：2016-11-01 00:00:00
abstract：:The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders. Toll-like receptors (TLR) are master regulators of innate immune function and involved in the activation of inflammatory responses in the brain. TLR3...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8995-z
更新日期：2016-01-01 00:00:00
abstract：:Smarcd1 is a component of an evolutionary conserved chromatin remodeling complex-SWI/SNF, which is involved in transcription factor recruitment, DNA replication, recombination, and repair. Suppression of the SWI/SNF complex required for cellular differentiation and gene regulation may be inducible for cell proliferati...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02190-z
更新日期：2020-11-14 00:00:00
abstract：:Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8642-8
更新日期：2014-10-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF), in addition to its neurotrophic action, also possesses antioxidant activities. However, the underlying mechanisms remain to be fully defined. Sestrin2 is a stress-responsive gene implicated in the cellular defense against oxidative stress. Currently, the potential functions of...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9357-1
更新日期：2016-08-01 00:00:00
abstract：:There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-011-8183-3
更新日期：2011-08-01 00:00:00
abstract：:The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:32:2:157
更新日期：2005-10-01 00:00:00
abstract：:Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes learning and memory deficits. Recently, it has been proved that the striatum is related to memory and learning ability. However, no previous study focused on the effect of Mn-induced learning and memory deficits on the striatum. This study aims ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9602-7
更新日期：2016-12-01 00:00:00
abstract：:Axonal damage is a major factor contributing to disease progression in multiple sclerosis (MS) patients. On the histological level, acute axonal injury is most frequently analyzed by anti-amyloid precursor protein immunohistochemistry. To what extent this method truly detects axonal injury, and whether other proteins ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1353-9
更新日期：2019-06-01 00:00:00
abstract：:Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-9029-6
更新日期：2016-01-01 00:00:00
abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0306-4
更新日期：2017-12-01 00:00:00
abstract：:Inflammation plays a crucial role in the pathogenesis of stroke. This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). Serum Lp(a) levels were determined in 203 ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0346-9
更新日期：2018-01-01 00:00:00
abstract：:The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0171-1
更新日期：2017-10-01 00:00:00
abstract：:Astrocytes are involved in many key physiological processes in the brain, including glutamatergic transmission, energy metabolism, and blood flow control. They become reactive in response to pathological situations, a response that involves well-described morphological alterations and less characterized functional cha...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-008-8043-y
更新日期：2008-12-01 00:00:00
abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0144-4
更新日期：2017-10-01 00:00:00
abstract：:Apoptosis plays a crucial role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). However, the exact molecular mechanisms underlying neuronal apoptosis in EBI after SAH have not been fully elucidated. The present study showed that EBI induced significantly neuronal apoptosis activ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9490-x
更新日期：2016-10-01 00:00:00
abstract：:Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8365-7
更新日期：2013-04-01 00:00:00
abstract：:Dodecafluoropentane emulsion (DDFPe) in 250 nm nanodroplets seems to swell modestly to accept and carry large amounts of oxygen in the body at >29 °C. Small particle size allows oxygen delivery even into hypoxic tissue unreachable by erythrocytes. Using permanent cerebral embolic occlusion in rabbits, we assessed DDFP...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8495-6
更新日期：2013-10-01 00:00:00
abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9399-4
更新日期：2016-09-01 00:00:00
abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-0002-5
更新日期：2007-08-01 00:00:00
abstract：:Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1444-7
更新日期：2019-07-01 00:00:00
abstract：:The effects and mechanism of action of oligodeoxyribonucleotides containing CpG motif (CpG-ODNs) on neuron cells are largely unexamined. Here, we found that CpG-A ODNs but not other types of CpG-ODNs induced neurite retraction and cell apoptosis of rat embryonic neurons in a TLR9-independent manner. These effects of C...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8275-8
更新日期：2012-06-01 00:00:00
abstract：:Lafora disease (LD, OMIM 254780, ORPHA501) is a fatal neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called Lafora bodies and caused, in the vast majority of cases, by mutations in either EPM2A or EPM2B genes, encoding respectively laforin and malin. In the last year...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8747-0
更新日期：2015-01-01 00:00:00
abstract：:Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effect...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9341-9
更新日期：2016-08-01 00:00:00
abstract：:The aim of this work was to study the effect of glucagon-like peptide-2 (GLP-2) on the cyclic guanosine monophosphate (cGMP) signalling pathway and whether insulin or epidermal growth factor (EGF) might modulate the effects of GLP-2. GLP-2 produced a dose-dependent decrease in intracellular sodium nitroprusside-induce...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8298-1
更新日期：2012-10-01 00:00:00
abstract：:Chronic hyperammonemia impairs spatial memory by altering membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus. Intracerebral administration of extracellular cGMP to hyperammonemic rats restores spatial memory and membrane expression of AMPA receptors. The underlying molecular mechanisms re...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1387-z
更新日期：2019-06-01 00:00:00
abstract：:Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9903-5
更新日期：2017-07-01 00:00:00
