Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression.

abstract：:Males are predominantly affected by autism spectrum disorders (ASD) with a prevalence ratio of 5:1. However, the underlying pathological mechanisms governing the male preponderance of ASD remain unclear. Recent studies suggested that epigenetic aberrations may cause synaptic dysfunctions, which might be related to the...

journal_title：Molecular neurobiology

authors： Kim KC,Choi CS,Kim JW,Han SH,Cheong JH,Ryu JH,Shin CY

更新日期：2016-01-01 00:00:00

abstract：:Social isolation during the vulnerable period of adolescence produces emotional dysregulation that often manifests as abnormal behavior in adulthood. The enduring consequence of isolation might be caused by a weakened ability to forget unpleasant memories. However, it remains unclear whether isolation affects unpleasa...

journal_title：Molecular neurobiology

authors： Liu JH,You QL,Wei MD,Wang Q,Luo ZY,Lin S,Huang L,Li SJ,Li XW,Gao TM

更新日期：2015-12-01 00:00:00

abstract：:Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could be associated with the pathophysiology of depression. This study investigated the markers of microglia and astrocyte activation as well as indoleamine 2,3-dioxygenase (IDO) expression in developmental programming after early lif...

journal_title：Molecular neurobiology

authors： Réus GZ,Silva RH,de Moura AB,Presa JF,Abelaira HM,Abatti M,Vieira A,Pescador B,Michels M,Ignácio ZM,Dal-Pizzol F,Quevedo J

更新日期：2019-02-01 00:00:00

abstract：:There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...

journal_title：Molecular neurobiology

authors： Rivera DS,Lindsay CB,Codocedo JF,Carreño LE,Cabrera D,Arrese MA,Vio CP,Bozinovic F,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:Thyroid hormone plays an important role in central nervous system (CNS) development, including the myelination of variable axonal calibers. It is well-established that thyroid hormone is required for the terminal differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes by inducing ra...

journal_title：Molecular neurobiology

authors： Lee JY,Petratos S

更新日期：2016-11-01 00:00:00

abstract：:Apoptosis plays a crucial role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). However, the exact molecular mechanisms underlying neuronal apoptosis in EBI after SAH have not been fully elucidated. The present study showed that EBI induced significantly neuronal apoptosis activ...

journal_title：Molecular neurobiology

authors： Feng D,Wang B,Ma Y,Shi W,Tao K,Zeng W,Cai Q,Zhang Z,Qin H

更新日期：2016-10-01 00:00:00

abstract：:Cholinergic system is very important for many higher brain functions, including learning and memory. Cholinergic neurons, especially those in the basal forebrain, are specifically susceptible in some neurodegenerative diseases, such as in Alzheimer's disease (AD). Here, we studied the cholinergic system lesion effects...

journal_title：Molecular neurobiology

authors： Yan H,Pang P,Chen W,Zhu H,Henok K A,Li H,Wu Z,Ke X,Wu J,Zhang T,Pan K,Pei L,Han Y,Lu Y

更新日期：2018-05-01 00:00:00

abstract：:Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that c...

journal_title：Molecular neurobiology

authors： Shin T,Kim J,Ahn M,Moon C

更新日期：2019-05-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...

journal_title：Molecular neurobiology

authors： Ribeiro FM,Pires RG,Ferguson SS

更新日期：2011-02-01 00:00:00

abstract：:Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in autophagy/m...

journal_title：Molecular neurobiology

authors： Feng J,Chen X,Guan B,Li C,Qiu J,Shen J

更新日期：2018-08-01 00:00:00

abstract：:(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...

journal_title：Molecular neurobiology

authors： Zhang JC,Xu H,Yuan Y,Chen JY,Zhang YJ,Lin Y,Yuan SY

更新日期：2017-07-01 00:00:00

abstract：:Statins have proven their effectiveness in the treatment of cardiovascular disease. This class of drugs has also attracted attention as a potential treatment for dissimilar diseases such as certain types of cancers and neurodegenerative diseases. What appears to be a contradiction is that, in the case of cancer, it ha...

journal_title：Molecular neurobiology

authors： Wood WG,Igbavboa U,Muller WE,Eckert GP

更新日期：2013-10-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:Glioblastoma (GBM) is a highly aggressive brain cancer with the worst prognosis of any central nervous system disease despite intensive multimodal therapy. Inevitably, glioblastoma is fatal, with recurrence of treatment-resistant tumour growth at distal sites leading to an extremely low median survival rate of 12-15 m...

journal_title：Molecular neurobiology

authors： Tivnan A,McDonald KL

更新日期：2013-12-01 00:00:00

abstract：:Neuropsin (NP) is a serine protease, implicated in synaptic plasticity and memory acquisition through cleavage of synaptic adhesion molecule, L1CAM. However, NP has not been explored during brain aging that entails drastic deterioration of plasticity and memory with selective regional vulnerability. Therefore, we have...

journal_title：Molecular neurobiology

authors： Konar A,Thakur MK

更新日期：2015-01-01 00:00:00

abstract：:Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...

journal_title：Molecular neurobiology

authors： Lee ST,Seo Y,Bae JY,Chu K,Kim JW,Choi SH,Kim TM,Kim IH,Park SH,Park CK

更新日期：2018-06-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Her...

journal_title：Molecular neurobiology

authors： Lieberknecht V,Junqueira SC,Cunha MP,Barbosa TA,de Souza LF,Coelho IS,Santos AR,Rodrigues AL,Dafré AL,Dutra RC

更新日期：2017-03-01 00:00:00

abstract：:Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects o...

journal_title：Molecular neurobiology

authors： Henn L,Zanta NC,Girardi CEN,Suchecki D

更新日期：2020-10-15 00:00:00

abstract：:Recent evidence suggests that hypoxia preconditioning can alter the microRNA (miRNA) profile of extracellular vesicles (EVs) and has better neuroprotective effects when enriched miRs are delivered to recipients. However, the roles of exosomal miRNAs in regulating ischaemia-reperfusion (IR)-induced pain hypersensitivit...

journal_title：Molecular neurobiology

authors： Wang H,Chen FS,Zhang ZL,Zhou HX,Ma H,Li XQ

更新日期：2021-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was re...

journal_title：Molecular neurobiology

authors： Heitzer M,Kaiser S,Kanagaratnam M,Zendedel A,Hartmann P,Beyer C,Johann S

更新日期：2017-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease affecting over five million individuals worldwide. The exact molecular events underlying PD pathogenesis are still not clearly known. Glia maturation factor (GMF), a neuroinflammatory protein in the brain plays an important role in the pathogenesis of...

journal_title：Molecular neurobiology

authors： Selvakumar GP,Iyer SS,Kempuraj D,Raju M,Thangavel R,Saeed D,Ahmed ME,Zahoor H,Raikwar SP,Zaheer S,Zaheer A

更新日期：2018-09-01 00:00:00

abstract：:OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy, chaperone activity, and apoptosis. Few studies on the role of OMI/HTRA2 in Alzheimer's disease (AD) are available, but none on its relationship with the cholinergi...

journal_title：Molecular neurobiology

authors： Darreh-Shori T,Rezaeianyazdi S,Lana E,Mitra S,Gellerbring A,Karami A,Bogdanovic N,Lithner CU,Winblad B,Behbahani H

更新日期：2019-07-01 00:00:00

abstract：:Many studies have shown that mitochondrial dysfunction and the subsequent oxidative stress caused by excessive reactive oxygen species (ROS) generation play a central role in the pathogenesis of Parkinson's disease (PD). We have previously shown that low-intensity ultrasound (LIUS) could reduce ROS generation by L-but...

journal_title：Molecular neurobiology

authors： Karmacharya MB,Hada B,Park SR,Choi BH

更新日期：2017-10-01 00:00:00

abstract：:Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the physiological mechanisms are not fully understood. Senescence-accelerated prone mouse (SAMP8) models were conducted under metabolic stress conditions by feeding HF for 15 weeks, and the preventive effect of resveratrol was...

journal_title：Molecular neurobiology

authors： Palomera-Avalos V,Griñán-Ferré C,Puigoriol-Ilamola D,Camins A,Sanfeliu C,Canudas AM,Pallàs M

更新日期：2017-04-01 00:00:00

abstract：:The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgeni...

journal_title：Molecular neurobiology

authors： Moutinho M,Nunes MJ,Gomes AQ,Gama MJ,Cedazo-Minguez A,Rodrigues CM,Björkhem I,Rodrigues E

更新日期：2015-01-01 00:00:00

abstract：:In the developing mammalian, neocortex gap junctions represent a transient, metabolic, and electrical communication system. These gap junctions may play a crucial role during the formation and refinement of neocortical synaptic circuitries. This article focuses on two major points. First, the influence of gap junction...

journal_title：Molecular neurobiology

authors： Rörig B,Sutor B

更新日期：1996-06-01 00:00:00

abstract：:The potassium channel tetramerization domain-containing protein 7 (KCTD7) was named after the structural homology of its predicted N-terminal broad complex, tramtrack and bric à brac/poxvirus and zinc finger domain with the T1 domain of the Kv potassium channel, but its expression profile and cellular function are sti...

journal_title：Molecular neurobiology

authors： Azizieh R,Orduz D,Van Bogaert P,Bouschet T,Rodriguez W,Schiffmann SN,Pirson I,Abramowicz MJ

更新日期：2011-08-01 00:00:00

abstract：:Oxidative stress is a key component of the pathological cascade in subarachnoid hemorrhage (SAH). Fucoxanthin (Fx) possesses a strong antioxidant property and has shown neuroprotective effects in acute brain injuries such as ischemic stroke and traumatic brain injury. Here, we investigated the beneficial effects of Fx...

journal_title：Molecular neurobiology

authors： Zhang XS,Lu Y,Tao T,Wang H,Liu GJ,Liu XZ,Liu C,Xia DY,Hang CH,Li W

更新日期：2020-12-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to play a critical role in the development of several malignancies. However, the potential molecular mechanism of MALAT1 in glioma remains unclear. In the present study, we found that the expression of MALAT1 wa...

journal_title：Molecular neurobiology

authors： Cheng H,Zhao H,Xiao X,Huang Q,Zeng W,Tian B,Ma T,Lu D,Jin Y,Li Y

更新日期：2020-10-19 00:00:00

abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...

journal_title：Molecular neurobiology

authors： Hochgräfe K,Mandelkow EM

更新日期：2013-06-01 00:00:00