Abstract：
:Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to play a critical role in the development of several malignancies. However, the potential molecular mechanism of MALAT1 in glioma remains unclear. In the present study, we found that the expression of MALAT1 was aberrantly increased in both human glioma tissues and cells and associated with poor prognosis in glioma patients. We further found that MALAT1 silencing significantly inhibited glioma cell proliferation while induced cell cycle arrest and apoptosis. In parallel, knockdown of MALAT1 decreased tumor volume in vivo. These results suggested that MALAT1 acts as a functional oncogene, resulting in the oncogenicity in glioma. Nevertheless, the tumor-suppressive effect of MALAT1 silencing was reversed by miR-124. Besides, the relevance of ZEB2 in tumor progression has been studied in several forms of human cancer, and ZEB2 was identified as a target of miR-124 and negatively regulated by miR-124. MALAT1 overexpression or miR-124 inhibitor led to increased expression of ZEB2. In summary, our study depicts a novel pathway of MALAT1/miR-124/ZEB2 that regulates the progression of glioma and might provide a promising strategy for glioma therapy.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Cheng H,Zhao H,Xiao X,Huang Q,Zeng W,Tian B,Ma T,Lu D,Jin Y,Li Ydoi
10.1007/s12035-020-02165-0subject
Has Abstractpub_date
2020-10-19 00:00:00eissn
0893-7648issn
1559-1182pii
10.1007/s12035-020-02165-0pub_type
杂志文章abstract：:Intracerebroventricular (icv) amyloid-beta (Aβ)1-40 infusion to mice has been demonstrated to cause neurotoxicty and depressive-like behavior and it can be used to evaluate antidepressant and neuroprotective effect of drugs. Atorvastatin is a widely used statin that has demonstrated antidepressant-like effect in predi...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0134-6
更新日期：2017-10-01 00:00:00
abstract：:The signaling cascades triggered by neurotrophins such as BDNF and by several neurotransmitters and hormones lead to the rapid induction of gene transcription by increasing the intracellular concentration of cAMP and Ca2+. This review examines the mechanisms by which these second messengers control transcriptional ini...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:30:1:091
更新日期：2004-08-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative brain pathology and the most common form of dementia. Evidence suggests that extracellular vesicles (EVs) containing cytokines and microRNA are involved in inflammation regulation. The current study aimed to explore a potential impact of AD patients' EVs on d...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02013-1
更新日期：2020-10-01 00:00:00
abstract：:Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9701-0
更新日期：2017-03-01 00:00:00
abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9399-4
更新日期：2016-09-01 00:00:00
abstract：:The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrPC). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein (PrPSc), levels of mature endogenous Sho become reduced. To study the regulatory effect of the proteostati...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1623-1
更新日期：2019-11-01 00:00:00
abstract：:Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal-lysosomal pathway. This mechanism plays an important role in homeostasis and it is defective in certain diseases. Preceding studies have revealed that autophagy is developing as an important moderato...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9827-0
更新日期：2017-05-01 00:00:00
abstract：:In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-01869-7
更新日期：2020-05-01 00:00:00
abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02108-9
更新日期：2021-01-01 00:00:00
abstract：:The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0857-z
更新日期：2018-08-01 00:00:00
abstract：:Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible stu...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析,收录出版
doi：10.1007/s12035-014-8823-5
更新日期：2015-01-01 00:00:00
abstract：:Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9148-8
更新日期：2016-04-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-010-8153-1
更新日期：2011-02-01 00:00:00
abstract：:Hypoxia, the major cause of ischemic injury, leads to debilitating disease in infants via birth asphyxia and cerebral palsy, whereas in adults via heart attack and stroke. A widespread, natural protective phenomenon termed 'hypoxic preconditioning' (PH) occurs when prior exposures to hypoxia eventually result in robus...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02091-1
更新日期：2020-12-01 00:00:00
abstract：:Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in functional motor and sensory loss, showing limited regeneration because of adverse microenvironment such as neuroinflammation and glial scarring. Currently, there is no effective therapy to treat SCI in clinical practice. Bone marrow...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9000-6
更新日期：2016-01-01 00:00:00
abstract：:AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neuronal loss. Growing evidences indicate that dysregulation of regulato...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8704-y
更新日期：2014-12-01 00:00:00
abstract：:For the epigenetic characterization of neuromyelitis optica (NMO), we determined whether messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in subjects with and without NMO. lncRNA and mRNA expression profiles of NMO patients and healthy controls were generated by using microarray an...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9754-0
更新日期：2017-04-01 00:00:00
abstract：:The development of in vitro amplification systems allows detecting femtomolar amounts of prion protein scrapie (PrP(Sc)) in human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects of prion disease type, codon 129 genotype, PrP(Sc) type, and other disease-related factors on the real-time quak...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8709-6
更新日期：2015-02-01 00:00:00
abstract：:Alzheimer's disease is the most common dementia afflicting the elderly in modern society. This disease arises from the neurotoxicity elicited by abnormal aggregates of amyloid-β (Aβ) protein. Such aggregates form through the cleavage of amyloid precursor protein (APP) by β-secretase and the subsequent proteolysis of t...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8580-x
更新日期：2014-04-01 00:00:00
abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0306-4
更新日期：2017-12-01 00:00:00
abstract：:Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elev...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02935554
更新日期：1991-01-01 00:00:00
abstract：:Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9518-2
更新日期：2016-11-01 00:00:00
abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-019-01863-8
更新日期：2020-04-01 00:00:00
abstract：:Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintain...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02277-7
更新日期：2021-01-28 00:00:00
abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0280-x
更新日期：2017-12-01 00:00:00
abstract：:Atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8925-0
更新日期：2015-12-01 00:00:00
abstract：:In the developing mammalian, neocortex gap junctions represent a transient, metabolic, and electrical communication system. These gap junctions may play a crucial role during the formation and refinement of neocortical synaptic circuitries. This article focuses on two major points. First, the influence of gap junction...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02755590
更新日期：1996-06-01 00:00:00
abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9423-8
更新日期：2016-10-01 00:00:00
abstract：:Parkinson's disease and other synucleinopathies are characterized by the presence of intra-neuronal protein aggregates enriched in the presynaptic protein α-synuclein. α-synuclein is considered an intrinsically disordered 14 kDa monomer, and although poorly understood, its transition to higher-order multimeric species...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0266-8
更新日期：2017-12-01 00:00:00
abstract：:Inflammation plays a crucial role in the pathogenesis of stroke. This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). Serum Lp(a) levels were determined in 203 ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0346-9
更新日期：2018-01-01 00:00:00
