Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways.

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...

journal_title：Molecular neurobiology

authors： Garcez ML,Mina F,Bellettini-Santos T,da Luz AP,Schiavo GL,Macieski JMC,Medeiros EB,Marques AO,Magnus NQ,Budni J

更新日期：2019-04-01 00:00:00

abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...

journal_title：Molecular neurobiology

authors： Yabuki Y,Takahata I,Matsuo K,Owada Y,Fukunaga K

更新日期：2018-04-01 00:00:00

abstract：:One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders ...

journal_title：Molecular neurobiology

authors： Sochocka M,Donskow-Łysoniewska K,Diniz BS,Kurpas D,Brzozowska E,Leszek J

更新日期：2019-03-01 00:00:00

abstract：:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...

journal_title：Molecular neurobiology

authors： Kruk-Slomka M,Banaszkiewicz I,Slomka T,Biala G

更新日期：2019-11-01 00:00:00

abstract：:The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...

journal_title：Molecular neurobiology

authors： Avolio E,Fazzari G,Mele M,Alò R,Zizza M,Jiao W,Di Vito A,Barni T,Mandalà M,Canonaco M

更新日期：2017-10-01 00:00:00

abstract：:Many studies have shown that mitochondrial dysfunction and the subsequent oxidative stress caused by excessive reactive oxygen species (ROS) generation play a central role in the pathogenesis of Parkinson's disease (PD). We have previously shown that low-intensity ultrasound (LIUS) could reduce ROS generation by L-but...

journal_title：Molecular neurobiology

authors： Karmacharya MB,Hada B,Park SR,Choi BH

更新日期：2017-10-01 00:00:00

abstract：:Hypoxia, the major cause of ischemic injury, leads to debilitating disease in infants via birth asphyxia and cerebral palsy, whereas in adults via heart attack and stroke. A widespread, natural protective phenomenon termed 'hypoxic preconditioning' (PH) occurs when prior exposures to hypoxia eventually result in robus...

journal_title：Molecular neurobiology

authors： Das T,Soren K,Yerasi M,Kamle A,Kumar A,Chakravarty S

更新日期：2020-12-01 00:00:00

abstract：:Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal ...

journal_title：Molecular neurobiology

authors： Lima LCF,Saliba SW,Andrade JMO,Cunha ML,Cassini-Vieira P,Feltenberger JD,Barcelos LS,Guimarães ALS,de-Paula AMB,de Oliveira ACP,Santos SHS

更新日期：2017-07-01 00:00:00

abstract：:Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of partic...

journal_title：Molecular neurobiology

authors： Abdullah AI,Pollock A,Sun T

更新日期：2012-06-01 00:00:00

abstract：:NMDA receptor signaling is critical for the development of synaptic plasticity, learning, and memory, and dysregulation of NMDAR signaling is implicated in a number of neurological disorders including schizophrenia (SZ). Previous work has demonstrated that the STriatal-Enriched protein tyrosine Phosphatase 61 kDa (STE...

journal_title：Molecular neurobiology

authors： Xu J,Kurup P,Nairn AC,Lombroso PJ

更新日期：2018-04-01 00:00:00

abstract：:Olfactory dysfunction is a recognized risk factor for the pathogenesis of Alzheimer's disease (AD), while the mechanisms are still not clear. Here, we applied bilateral olfactory bulbectomy (OBX), an olfactory deprivation surgery to cause permanent anosmia, in human tau-overexpressed mice (htau mice) to investigate ch...

journal_title：Molecular neurobiology

authors： Li K,Liu FF,He CX,Huang HZ,Xie AJ,Hu F,Liu D,Wang JZ,Zhu LQ

更新日期：2016-01-01 00:00:00

abstract：:Maternal separation (MS) causes long-lasting epigenetic changes in the brain and increases vulnerability to traumatic events in adulthood. Of interest, there may be sex-specific differences in these epigenetic changes. In this study, the extent of histone acetylation in the hippocampus (HIP) and the expression of BDNF...

journal_title：Molecular neurobiology

authors： Sun H,Zhang X,Kong Y,Gou L,Lian B,Wang Y,Jiang L,Li Q,Sun H,Sun L

更新日期：2020-11-27 00:00:00

abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...

journal_title：Molecular neurobiology

authors： Oliveira SR,Figueiredo-Pereira C,Duarte CB,Vieira HLA

更新日期：2019-05-01 00:00:00

abstract：:Glioblastoma (GBM) is a highly aggressive brain cancer with the worst prognosis of any central nervous system disease despite intensive multimodal therapy. Inevitably, glioblastoma is fatal, with recurrence of treatment-resistant tumour growth at distal sites leading to an extremely low median survival rate of 12-15 m...

journal_title：Molecular neurobiology

authors： Tivnan A,McDonald KL

更新日期：2013-12-01 00:00:00

abstract：:An increasing number of circulating micro-ribonucleic acids (microRNAs, miRNAs) have been discovered its potential as biomarkers to diagnose neurodegenerative diseases (NDs) by many researchers. However, there were obvious inconsistencies among previous studies, and thus we performed this meta-analysis to evaluate whe...

journal_title：Molecular neurobiology

authors： Zi Y,Yin Z,Xiao W,Liu X,Gao Z,Jiao L,Deng L

更新日期：2015-12-01 00:00:00

abstract：:Lafora disease (LD, OMIM 254780, ORPHA501) is a fatal neurodegenerative disorder characterized by the presence of glycogen-like intracellular inclusions called Lafora bodies and caused, in the vast majority of cases, by mutations in either EPM2A or EPM2B genes, encoding respectively laforin and malin. In the last year...

journal_title：Molecular neurobiology

authors： Romá-Mateo C,Aguado C,García-Giménez JL,Ibáñez-Cabellos JS,Seco-Cervera M,Pallardó FV,Knecht E,Sanz P

更新日期：2015-01-01 00:00:00

abstract：:Hippocampus-dependent memories, such as social recognition (SRM), are modulated by neurogenesis. However, the precise role of newborn neurons in social memory processing is still unknown. We showed previously that 1 week of enriched environment (EE) is sufficient to increase neurogenesis in the hippocampus (HIP) and t...

journal_title：Molecular neurobiology

authors： Pereira-Caixeta AR,Guarnieri LO,Pena RR,Dias TL,Pereira GS

更新日期：2017-07-01 00:00:00

abstract：:The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgeni...

journal_title：Molecular neurobiology

authors： Moutinho M,Nunes MJ,Gomes AQ,Gama MJ,Cedazo-Minguez A,Rodrigues CM,Björkhem I,Rodrigues E

更新日期：2015-01-01 00:00:00

abstract：:Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasop...

journal_title：Molecular neurobiology

authors： Richards EM,Raizada MK,Gelband CH,Sumners C

更新日期：1999-02-01 00:00:00

abstract：:Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...

journal_title：Molecular neurobiology

authors： Raina A,Mahajani S,Bähr M,Kügler S

更新日期：2020-01-01 00:00:00

abstract：:While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...

journal_title：Molecular neurobiology

authors： Otero A,Bolea R,Hedman C,Fernández-Borges N,Marín B,López-Pérez Ó,Barrio T,Eraña H,Sánchez-Martín MA,Monzón M,Badiola JJ,Castilla J

更新日期：2018-07-01 00:00:00

abstract：:Once infected by HIV-1, microglia abundantly produce accessory protein Nef that enhances virus production and infectivity, but little is known about its intracellular compartmentalization, trafficking mode(s), and release from microglia. Here, we transfected immortalized human microglia with a plasmid encoding Nef tag...

journal_title：Molecular neurobiology

authors： Stenovec M,Lasič E,Dominkuš PP,Bobnar ST,Zorec R,Lenassi M,Kreft M

更新日期：2019-01-01 00:00:00

abstract：:L-DOPA is the main pharmacological therapy for Parkinson's disease. However, long-term exposure to L-DOPA induces involuntary movements termed dyskinesia. Clinical trials show that dyskinesia is attenuated by metabotropic glutamate receptor type 5 (mGluR5) antagonists. Further, the onset of dyskinesia is delayed by ni...

journal_title：Molecular neurobiology

authors： García-Montes JR,Solís O,Enríquez-Traba J,Ruiz-DeDiego I,Drucker-Colín R,Moratalla R

更新日期：2019-06-01 00:00:00

abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...

journal_title：Molecular neurobiology

authors： Hochgräfe K,Mandelkow EM

更新日期：2013-06-01 00:00:00

abstract：:Prion pathologies are characterized by the conformational conversion of the cellular prion protein (PrPC) into a pathological infectious isoform, known as PrPSc. The latter acquires different abnormal conformations, which are associated with specific pathological phenotypes. Recent evidence suggests that prions adapt ...

journal_title：Molecular neurobiology

authors： Bistaffa E,Moda F,Virgilio T,Campagnani I,De Luca CMG,Rossi M,Salzano G,Giaccone G,Tagliavini F,Legname G

更新日期：2019-04-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...

journal_title：Molecular neurobiology

authors： Zieger E,Candiani S,Garbarino G,Croce JC,Schubert M

更新日期：2018-06-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...

journal_title：Molecular neurobiology

authors： Igel-Egalon A,Laferrière F,Tixador P,Moudjou M,Herzog L,Reine F,Torres JM,Laude H,Rezaei H,Béringue V

更新日期：2020-06-01 00:00:00

abstract：:Prenatal ethanol exposure can cause extensive apoptotic neurodegeneration throughout the developing central nervous system (CNS), which results in cognitive deficits and memory decline. However, the underlying mechanisms need further study. Single-minded 2 (Sim2), a transcriptional repressor, is reportedly involved in...

journal_title：Molecular neurobiology

authors： Wang X,Yang Z,Sun Y,Zhou H,Chu G,Zhang J,Meng X

更新日期：2015-12-01 00:00:00

abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...

journal_title：Molecular neurobiology

authors： Fröhlich C,Zschiebsch K,Gröger V,Paarmann K,Steffen J,Thurm C,Schropp EM,Brüning T,Gellerich F,Radloff M,Schwabe R,Lachmann I,Krohn M,Ibrahim S,Pahnke J

更新日期：2016-09-01 00:00:00