Abstract：
:One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders like Alzheimer's disease (AD). Although human-associated microbial communities are generally stable, they can be altered by common human actions and experiences. Enteric bacteria, commensal, and pathogenic microorganisms, may have a major impact on immune system, brain development, and behavior, as they are able to produce several neurotransmitters and neuromodulators like serotonin, kynurenine, catecholamine, etc., as well as amyloids. However, brain destructive mechanisms, that can lead to dementia and AD, start with the intestinal microbiome dysbiosis, development of local and systemic inflammation, and dysregulation of the gut-brain axis. Increased permeability of the gut epithelial barrier results in invasion of different bacteria, viruses, and their neuroactive products that support neuroinflammatory reactions in the brain. It seems that, inflammatory-infectious hypothesis of AD, with the great role of the gut microbiome, starts to gently push into the shadow the amyloid cascade hypothesis that has dominated for decades. It is strongly postulated that AD may begin in the gut, and is closely related to the imbalance of gut microbiota. This is promising area for therapeutic intervention. Modulation of gut microbiota through personalized diet or beneficial microbiota intervention, alter microbial partners and their products including amyloid protein, will probably become a new treatment for AD.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Sochocka M,Donskow-Łysoniewska K,Diniz BS,Kurpas D,Brzozowska E,Leszek Jdoi
10.1007/s12035-018-1188-4subject
Has Abstractpub_date
2019-03-01 00:00:00pages
1841-1851issue
3eissn
0893-7648issn
1559-1182pii
10.1007/s12035-018-1188-4journal_volume
56pub_type
杂志文章,评审abstract：:There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0795-9
更新日期：2018-07-01 00:00:00
abstract：:In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depres...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9693-9
更新日期：2016-11-01 00:00:00
abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-01897-3
更新日期：2020-06-01 00:00:00
abstract：:Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:27:3:239
更新日期：2003-06-01 00:00:00
abstract：:We have recently demonstrated that δ-opioid receptor (DOR) activation attenuates α-synuclein expression/aggregation induced by MPP(+) and/or severe hypoxia. Since α-synuclein plays a critical role in the pathogenesis of Parkinson's disease, DOR activation may trigger an antiparkinson pathway(s) against α-synuclein-ind...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1316-1
更新日期：2019-05-01 00:00:00
abstract：:Lactate is an energy substrate in adult brain especially when glucose is withdrawn or only lactate is present as main energy source. Besides, the most abundant lactate transporter in brain-monocarboxylate transporter 1 (MCT1)-was recognized recently. Despite this, MCT1 expressions in central nervous system (CNS) have ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9820-7
更新日期：2017-04-01 00:00:00
abstract：:Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational regulation, stress granule formation, cell cycle regulation, and axonal t...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02137-4
更新日期：2021-02-01 00:00:00
abstract：:Apoptosis plays a crucial role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). However, the exact molecular mechanisms underlying neuronal apoptosis in EBI after SAH have not been fully elucidated. The present study showed that EBI induced significantly neuronal apoptosis activ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9490-x
更新日期：2016-10-01 00:00:00
abstract：:Alzheimer's disease is the most common dementia afflicting the elderly in modern society. This disease arises from the neurotoxicity elicited by abnormal aggregates of amyloid-β (Aβ) protein. Such aggregates form through the cleavage of amyloid precursor protein (APP) by β-secretase and the subsequent proteolysis of t...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8580-x
更新日期：2014-04-01 00:00:00
abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9248-5
更新日期：2015-10-01 00:00:00
abstract：:Hypoxia, the major cause of ischemic injury, leads to debilitating disease in infants via birth asphyxia and cerebral palsy, whereas in adults via heart attack and stroke. A widespread, natural protective phenomenon termed 'hypoxic preconditioning' (PH) occurs when prior exposures to hypoxia eventually result in robus...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02091-1
更新日期：2020-12-01 00:00:00
abstract：:Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that c...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-1341-0
更新日期：2019-05-01 00:00:00
abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0639-7
更新日期：2018-05-01 00:00:00
abstract：:Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3CL1/CX3CR1 axis is associated with the development of ischemic oligodendrocyte and white matter injury. We inve...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9339-3
更新日期：2016-08-01 00:00:00
abstract：:The neuronal circuit remodels during development as well as in human neuropathologies such as epilepsy. Neurite outgrowth is an obligatory step in these events. We recently reported that alterations in the phosphorylation state of an axon specification/guidance protein, the collapsin response mediator protein 2 (CRMP2...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9141-2
更新日期：2016-04-01 00:00:00
abstract：:Neuropsin (NP) is a serine protease, implicated in synaptic plasticity and memory acquisition through cleavage of synaptic adhesion molecule, L1CAM. However, NP has not been explored during brain aging that entails drastic deterioration of plasticity and memory with selective regional vulnerability. Therefore, we have...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8780-z
更新日期：2015-01-01 00:00:00
abstract：:This study examined the effects of pinealectomy in Wistar rats and melatonin replacement therapy on the daily mRNA expression of melatonin (Tph1, Aanat, Asmt, Mt1, Mt2, and Rorα), and steroidogenic (Star, 17βhsd3, and Lhr) related genes as well as clock genes (Rev-erbα, Bmal1, Per1, Per2, Cry1, and Cry2) in testes. Th...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1626-y
更新日期：2019-11-01 00:00:00
abstract：:Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1049-1
更新日期：2018-12-01 00:00:00
abstract：:The survival of an organism depends on its ability to respond to its environment through its senses. The sense of touch is one of the most vital; still, it is the least understood. In the process of touch sensation, a mechanical stimulus is converted into electrical signals. Groundbreaking electrophysiological experim...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-8009-5
更新日期：2007-12-01 00:00:00
abstract：:The study of neurite growth in tissue culture has been a productive way to identify substances that may control the behavior of axons in vivo. Molecules that promote the outgrowth of neurites include nerve growth factor, laminin, fibronectin, and a protease inhibitor derived from glia. Evidence that these molecules ma...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02936609
更新日期：1987-10-01 00:00:00
abstract：:Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron death in the substantia nigra (SN) and subsequent striatal adaptations. Mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) are widely used as a model for PD. To assess the validity of the MPTP mouse model for PD p...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9103-8
更新日期：2016-04-01 00:00:00
abstract：:The transition from occasional to escalated psychostimulant use is accelerated by prior drug exposure. These behavioral observations may be related to long-lasting transcriptional and/or epigenetic changes induced by the drug pre-exposure. Herein, we investigated if a single methamphetamine (METH) injection would enha...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01830-3
更新日期：2020-03-01 00:00:00
abstract：:Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02086-y
更新日期：2021-01-01 00:00:00
abstract：:PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellula...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02242-4
更新日期：2021-01-07 00:00:00
abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02935639
更新日期：1993-07-01 00:00:00
abstract：:Military personnel are often subjected to sleep deprivation (SD) during combat operations. Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility exists that acute or long-term SD will influence blood-brain barrier (BBB) function and brain pathology. This hypothesis was examined in...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9236-9
更新日期：2015-10-01 00:00:00
abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0306-4
更新日期：2017-12-01 00:00:00
abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8740-7
更新日期：2015-04-01 00:00:00
abstract：:The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-010-8127-3
更新日期：2010-08-01 00:00:00
abstract：:The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders. Toll-like receptors (TLR) are master regulators of innate immune function and involved in the activation of inflammatory responses in the brain. TLR3...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8995-z
更新日期：2016-01-01 00:00:00
