A role for potassium permeability in the recognition, clearance, and anti-inflammatory effects of apoptotic cells.

abstract：:OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy, chaperone activity, and apoptosis. Few studies on the role of OMI/HTRA2 in Alzheimer's disease (AD) are available, but none on its relationship with the cholinergi...

journal_title：Molecular neurobiology

authors： Darreh-Shori T,Rezaeianyazdi S,Lana E,Mitra S,Gellerbring A,Karami A,Bogdanovic N,Lithner CU,Winblad B,Behbahani H

更新日期：2019-07-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...

journal_title：Molecular neurobiology

authors： Eskandari-Sedighi G,Cortez LM,Yang J,Daude N,Shmeit K,Sim V,Westaway D

更新日期：2021-01-01 00:00:00

abstract：:The development of technologies for high-resolution nucleic acid localization in cells and tissues has contributed significantly to our understanding of transcriptional and translational regulation in eukaryotic cells. These methods include nonisotopic in situ hybridization methods for light and electron microscopy, a...

journal_title：Molecular neurobiology

authors： Martone ME,Pollock JA,Ellisman MH

更新日期：1998-12-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...

journal_title：Molecular neurobiology

authors： Wu Z,Yang L,Wang Y

更新日期：2014-10-01 00:00:00

abstract：:Tonic inhibition mediated by ambient levels of GABA that activate extrasynaptic GABAA receptors emerges as an essential factor that tunes neuronal network excitability in vitro and shapes behavioral responses in vivo. To address the role of neuromodulatory transmitter systems on this type of inhibition, we employed pa...

journal_title：Molecular neurobiology

authors： Meis S,Endres T,Munsch T,Lessmann V

更新日期：2018-11-01 00:00:00

abstract：:Recent progress in molecular biology has markedly expanded our knowledge of the molecular mechanism behind the proliferation and differentiation processes of Schwann cells, the myelin-forming cells in peripheral nervous systems. Intracellular signaling molecules participate in integrating various stimuli from cytokine...

journal_title：Molecular neurobiology

authors： Ogata T,Yamamoto S,Nakamura K,Tanaka S

更新日期：2006-02-01 00:00:00

abstract：:The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved in mediating fast excitatory synaptic transmission. Recent studies in both heterologous expression systems and cultured neurons have shown that the AMPA recept...

journal_title：Molecular neurobiology

authors： Wang JQ,Arora A,Yang L,Parelkar NK,Zhang G,Liu X,Choe ES,Mao L

更新日期：2005-12-01 00:00:00

abstract：:The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic...

journal_title：Molecular neurobiology

authors： Yan RT,Ma W,Liang L,Wang SZ

更新日期：2005-10-01 00:00:00

abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...

journal_title：Molecular neurobiology

authors： Schlief ML,Gitlin JD

更新日期：2006-04-01 00:00:00

abstract：:Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with ...

journal_title：Molecular neurobiology

authors： Biala G,Pekala K,Boguszewska-Czubara A,Michalak A,Kruk-Slomka M,Budzynska B

更新日期：2017-03-01 00:00:00

abstract：:The signaling cascades triggered by neurotrophins such as BDNF and by several neurotransmitters and hormones lead to the rapid induction of gene transcription by increasing the intracellular concentration of cAMP and Ca2+. This review examines the mechanisms by which these second messengers control transcriptional ini...

journal_title：Molecular neurobiology

authors： Gabellini N

更新日期：2004-08-01 00:00:00

abstract：:The administration of the anorexigenic drug d,l-fenfluramine (Ponderax) to laboratory animals results in a dose-dependent reduction in presynaptically located serotonergic reuptake transporter protein. This long-term effect may represent an altered mechanism of synthesis of the transporter (downregulation). Alternativ...

journal_title：Molecular neurobiology

authors： Westphalen RI,Dodd PR

更新日期：1995-08-01 00:00:00

abstract：:The characteristic functions of tissues and organs result from the integrated activity of individual cells. Nowhere is this more evident than in the nervous system, where the activities of single neurons communicating via electrical and chemical signals mediate complex functions, such as learning and memory. The past ...

journal_title：Molecular neurobiology

authors： O'Dowd DK,Smith MA

更新日期：1996-12-01 00:00:00

abstract：:Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ganglion cell neuroprotection and axon regeneration. Here, we show that...

journal_title：Molecular neurobiology

authors： Stevens AR,Ahmed U,Vigneswara V,Ahmed Z

更新日期：2019-11-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circR...

journal_title：Molecular neurobiology

authors： Gasparini S,Del Vecchio G,Gioiosa S,Flati T,Castrignano T,Legnini I,Licursi V,Ricceri L,Scattoni ML,Rinaldi A,Presutti C,Mannironi C

更新日期：2020-05-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have shown promise as a rapid-acting antidepressant drugs although with adve...

journal_title：Molecular neurobiology

authors： Gordillo-Salas M,Pascual-Antón R,Ren J,Greer J,Adell A

更新日期：2020-08-01 00:00:00

abstract：:Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...

journal_title：Molecular neurobiology

authors： Wang J,Yu JT,Tan L

更新日期：2015-04-01 00:00:00

abstract：:Neurodegenerative diseases represent a heterogeneous group of disorders whose common characteristic is the progressive degeneration of neuronal structure and function. Although much knowledge has been accumulated on the pathophysiology of neurodegenerative diseases over the years, more efforts are needed to understand...

journal_title：Molecular neurobiology

authors： Ferrero H,Larrayoz IM,Gil-Bea FJ,Martínez A,Ramírez MJ

更新日期：2018-12-01 00:00:00

abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...

journal_title：Molecular neurobiology

authors： Marcello E,Musardo S,Vandermeulen L,Pelucchi S,Gardoni F,Santo N,Antonucci F,Di Luca M

更新日期：2019-10-01 00:00:00

abstract：:Several studies support a protective effect of vitamin D on multiple sclerosis and experimental allergic encephalomyelitis (EAE), but the mechanisms of these favorable effects are unclear. Our study demonstrates that sphingosine 1-phosphate (S1P) is upregulated in the serum and spinal cords of EAE rats, but that vitam...

journal_title：Molecular neurobiology

authors： Zhu Y,Qin Z,Gao J,Yang M,Qin Y,Shen T,Liu S

更新日期：2014-12-01 00:00:00

abstract：:Enriched environment (EE) protects the retina from adult rats against ischemia/reperfusion (I/R) injury; however, how the components of EE contribute to the recovery after retinal ischemic damage remains unclear. We analyzed the contribution of social, cognitive, and visual stimulation on functional and histological a...

journal_title：Molecular neurobiology

authors： Fleitas MFG,Aranda ML,Diéguez HH,Milne G,Langellotti L,Miranda M,Altschuler F,Dorfman D,Rosenstein RE

更新日期：2020-01-01 00:00:00

abstract：:The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and adminis...

journal_title：Molecular neurobiology

authors： Wiklund L,Patnaik R,Sharma A,Miclescu A,Sharma HS

更新日期：2018-01-01 00:00:00

abstract：:Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...

journal_title：Molecular neurobiology

authors： Breydo L,Morgan D,Uversky VN

更新日期：2016-04-01 00:00:00

abstract：:Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...

journal_title：Molecular neurobiology

authors： Zhang M,Gong JX,Wang JL,Jiang MY,Li L,Hu YY,Qi J,Zhang LY,Zhao H,Cui X,Xian XH,Li WB

更新日期：2017-01-01 00:00:00

abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...

journal_title：Molecular neurobiology

authors： Chiang WC,Kroeger H,Sakami S,Messah C,Yasumura D,Matthes MT,Coppinger JA,Palczewski K,LaVail MM,Lin JH

更新日期：2015-08-01 00:00:00

abstract：:The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that helps regulate inflammatory pain sensation and nociception and the development of inflammatory diseases. However, the potential role of the TRPA1 channel and the underlying mechanism in brain functions are not fully resol...

journal_title：Molecular neurobiology

authors： Lee KI,Lin HC,Lee HT,Tsai FC,Lee TS

更新日期：2017-07-01 00:00:00

abstract：:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...

journal_title：Molecular neurobiology

authors： Kruk-Slomka M,Banaszkiewicz I,Slomka T,Biala G

更新日期：2019-11-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in functional motor and sensory loss, showing limited regeneration because of adverse microenvironment such as neuroinflammation and glial scarring. Currently, there is no effective therapy to treat SCI in clinical practice. Bone marrow...

journal_title：Molecular neurobiology

authors： Zhao H,Cheng L,Du X,Hou Y,Liu Y,Cui Z,Nie L

更新日期：2016-01-01 00:00:00

abstract：:Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...

journal_title：Molecular neurobiology

authors： Malenka RC

更新日期：1991-01-01 00:00:00