Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice.

abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...

journal_title：Molecular neurobiology

authors： Fonseca AC,Moreira PI,Oliveira CR,Cardoso SM,Pinton P,Pereira CF

更新日期：2015-04-01 00:00:00

abstract：:Smarcd1 is a component of an evolutionary conserved chromatin remodeling complex-SWI/SNF, which is involved in transcription factor recruitment, DNA replication, recombination, and repair. Suppression of the SWI/SNF complex required for cellular differentiation and gene regulation may be inducible for cell proliferati...

journal_title：Molecular neurobiology

authors： Zhu Y,Wang H,Fei M,Tang T,Niu W,Zhang L

更新日期：2020-11-14 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of ...

journal_title：Molecular neurobiology

authors： Silva RBM,Greggio S,Venturin GT,da Costa JC,Gomez MV,Campos MM

更新日期：2018-12-01 00:00:00

abstract：:The goal of this study was to evaluate if the immunohistochemical expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death, determining the possible use of sympathetic thoracic ganglia from subjects after brain death as study group. The third left ...

journal_title：Molecular neurobiology

authors： de Moura Júnior NB,das-Neves-Pereira JC,de Campos JR,de Oliveira FR,Wolosker N,Parra ER,Capelozzi VL,Jatene FB

更新日期：2012-04-01 00:00:00

abstract：:Among five members of the K+-dependent Na+/Ca2+ exchanger (NCKX) family (NCKX1-5), only NCKX2 is highly expressed in mouse brain. NCKX2 in plasma membranes mediates cytosolic calcium excretion through electrogenic exchange of 4 Na+ for 1 Ca2+ and 1 K+. Here, we observed significantly decreased levels of NCKX2 protein ...

journal_title：Molecular neurobiology

authors： Moriguchi S,Kita S,Yabuki Y,Inagaki R,Izumi H,Sasaki Y,Tagashira H,Horie K,Takeda J,Iwamoto T,Fukunaga K

更新日期：2018-05-01 00:00:00

abstract：:The aim of this work was to study the effect of glucagon-like peptide-2 (GLP-2) on the cyclic guanosine monophosphate (cGMP) signalling pathway and whether insulin or epidermal growth factor (EGF) might modulate the effects of GLP-2. GLP-2 produced a dose-dependent decrease in intracellular sodium nitroprusside-induce...

journal_title：Molecular neurobiology

authors： Velázquez E,Blázquez E,Ruiz-Albusac JM

更新日期：2012-10-01 00:00:00

abstract：:Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...

journal_title：Molecular neurobiology

authors： Weise SC,Arumugam G,Villarreal A,Videm P,Heidrich S,Nebel N,Dumit VI,Sananbenesi F,Reimann V,Craske M,Schilling O,Hess WR,Fischer A,Backofen R,Vogel T

更新日期：2019-07-01 00:00:00

abstract：:Neurological dysfunction as a result of neuroinflammation has been reported in sepsis and cause high mortality. High levels of cytokines stimulate the formation of neurotoxic metabolites by kynurenine (KYN) pathway. Vitamin B6 (vit B6) has anti-inflammatory and antioxidant properties and also acts as a cofactor for en...

journal_title：Molecular neurobiology

authors： Danielski LG,Giustina AD,Goldim MP,Florentino D,Mathias K,Garbossa L,de Bona Schraiber R,Laurentino AOM,Goulart M,Michels M,de Queiroz KB,Kohlhof M,Rezin GT,Fortunato JJ,Quevedo J,Barichello T,Dal-Pizzol F,Coimbra RS,

更新日期：2018-06-01 00:00:00

abstract：:Germline and somatic mutations in key genes of the mammalian target of rapamycin (mTOR) pathway have been identified in seizure-associated disorders. mTOR mutations lead to aberrant activation of mTOR signaling, and, although affected neurons are critical for epileptogenesis, the role of mTOR activation in glial cells...

journal_title：Molecular neurobiology

authors： Wang X,Sha L,Sun N,Shen Y,Xu Q

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress is a key component of the pathological cascade in subarachnoid hemorrhage (SAH). Fucoxanthin (Fx) possesses a strong antioxidant property and has shown neuroprotective effects in acute brain injuries such as ischemic stroke and traumatic brain injury. Here, we investigated the beneficial effects of Fx...

journal_title：Molecular neurobiology

authors： Zhang XS,Lu Y,Tao T,Wang H,Liu GJ,Liu XZ,Liu C,Xia DY,Hang CH,Li W

更新日期：2020-12-01 00:00:00

abstract：:We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed ...

journal_title：Molecular neurobiology

authors： Lopez JR,Uryash A,Kolster J,Estève E,Zhang R,Adams JA

更新日期：2018-11-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...

journal_title：Molecular neurobiology

authors： Kira J

更新日期：1994-04-01 00:00:00

abstract：:This study examined the effects of pinealectomy in Wistar rats and melatonin replacement therapy on the daily mRNA expression of melatonin (Tph1, Aanat, Asmt, Mt1, Mt2, and Rorα), and steroidogenic (Star, 17βhsd3, and Lhr) related genes as well as clock genes (Rev-erbα, Bmal1, Per1, Per2, Cry1, and Cry2) in testes. Th...

journal_title：Molecular neurobiology

authors： Coelho LA,Andrade-Silva J,Motta-Teixeira LC,Amaral FG,Reiter RJ,Cipolla-Neto J

更新日期：2019-11-01 00:00:00

abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

journal_title：Molecular neurobiology

authors： Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

更新日期：2018-10-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...

journal_title：Molecular neurobiology

authors： Zhong S,Zhao Z,Xie W,Cai Y,Zhang Y,Ding J,Wang X

更新日期：2021-01-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the physiological mechanisms are not fully understood. Senescence-accelerated prone mouse (SAMP8) models were conducted under metabolic stress conditions by feeding HF for 15 weeks, and the preventive effect of resveratrol was...

journal_title：Molecular neurobiology

authors： Palomera-Avalos V,Griñán-Ferré C,Puigoriol-Ilamola D,Camins A,Sanfeliu C,Canudas AM,Pallàs M

更新日期：2017-04-01 00:00:00

abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...

journal_title：Molecular neurobiology

authors： Oksdath M,Guil AFN,Grassi D,Sosa LJ,Quiroga S

更新日期：2017-10-01 00:00:00

abstract：:Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...

journal_title：Molecular neurobiology

authors： Prestigio C,Ferrante D,Valente P,Casagrande S,Albanesi E,Yanagawa Y,Benfenati F,Baldelli P

更新日期：2019-09-01 00:00:00

abstract：:The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...

journal_title：Molecular neurobiology

authors： Semple E,Shalabi F,Hill JW

更新日期：2019-09-01 00:00:00

abstract：:In this study, we investigated the influence of elevated RAS expression on the growth of meningioma in vivo and in vitro. The IOMM-LEE cells, representing a cell line derived from malignant meningioma, were divided into blank control group (cells without any drug treatment), negative control group (cells treated with ...

journal_title：Molecular neurobiology

authors： Jiang C,Song T,Li J,Ao F,Gong X,Lu Y,Zhang C,Chen L,Liu Y,He H,Huang O

更新日期：2017-01-01 00:00:00

abstract：:Accumulating evidence demonstrated that GABAergic dysfunction contributes to the pathogenesis of Alzheimer's disease (AD). The GABA aminotransferase (ABAT) gene encodes a mitochondrial GABA transaminase and plays key roles in the biogenesis and metabolism of gamma-aminobutyric acid (GABA), which is a major inhibitory ...

journal_title：Molecular neurobiology

authors： Zheng Q,Bi R,Xu M,Zhang DF,Tan LW,Lu YP,Yao YG

更新日期：2021-01-06 00:00:00

abstract：:For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...

journal_title：Molecular neurobiology

authors： Leuner B,Shors TJ

更新日期：2004-04-01 00:00:00

abstract：:The discovery of α-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by α-synuclein accumulation. In fact, as compared with pre-α-synuclein times, a "new" PD can now be described as a whole-body disease in which a progre...

journal_title：Molecular neurobiology

authors： Ulusoy A,Di Monte DA

更新日期：2013-04-01 00:00:00

abstract：:This work was aimed at investigating the circulating microRNA (miRNA) profiles in serum and saliva of patients affected by fibromyalgia syndrome (FM), correlating their expression values with clinical and clinimetric parameters and to suggest a mathematical model for the diagnosis of FM. A number of 14 FM patients and...

journal_title：Molecular neurobiology

authors： Masotti A,Baldassarre A,Guzzo MP,Iannuccelli C,Barbato C,Di Franco M

更新日期：2017-11-01 00:00:00

abstract：:c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, are involved in the regulation of several physiological functions in mammals and act as mediators of apoptosis, obesity, and memory storage in the brain, including the processes of neuronal de- and regeneration. JNK subf...

journal_title：Molecular neurobiology

authors： Petrov D,Luque M,Pedrós I,Ettcheto M,Abad S,Pallàs M,Verdaguer E,Auladell C,Folch J,Camins A

更新日期：2016-11-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...

journal_title：Molecular neurobiology

authors： Wu Z,Yang L,Wang Y

更新日期：2014-10-01 00:00:00

abstract：:Recent progress in molecular biology has markedly expanded our knowledge of the molecular mechanism behind the proliferation and differentiation processes of Schwann cells, the myelin-forming cells in peripheral nervous systems. Intracellular signaling molecules participate in integrating various stimuli from cytokine...

journal_title：Molecular neurobiology

authors： Ogata T,Yamamoto S,Nakamura K,Tanaka S

更新日期：2006-02-01 00:00:00

abstract：:Spinal cord injury (SCI) is a traumatic event resulting in disturbances to normal sensory, motor, or autonomic functions, which ultimately impacts a patient's physical, psychological, and social well-being. Until now, no available therapy for SCI can effectively slow down or halt the disease progression. Compared to t...

journal_title：Molecular neurobiology

authors： Yang H,Liu CC,Wang CY,Zhang Q,An J,Zhang L,Hao DJ

更新日期：2016-07-01 00:00:00

abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...

journal_title：Molecular neurobiology

authors： Lu AQ,Barnstable CJ

更新日期：2019-09-01 00:00:00