Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.

abstract：:The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...

journal_title：Molecular neurobiology

authors： García-Ayllón MS,Botella-López A,Cuchillo-Ibañez I,Rábano A,Andreasen N,Blennow K,Ávila J,Sáez-Valero J

更新日期：2017-01-01 00:00:00

abstract：:The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...

journal_title：Molecular neurobiology

authors： Zhu XC,Wang HF,Jiang T,Lu H,Tan MS,Tan CC,Tan L,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2017-01-01 00:00:00

abstract：:The loss of dopaminergic (DA) neurons in the substantia nigra (SN) is a major feature in the pathology of Parkinson's disease (PD). Using neural stem or progenitor cells (NSC/NPCs), the prospect of replacing the missing or damaged DA neurons is very attractive for PD therapy. However, little is known about the endogen...

journal_title：Molecular neurobiology

authors： Zhou Y,Zhu J,Lv Y,Song C,Ding J,Xiao M,Lu M,Hu G

更新日期：2018-11-01 00:00:00

abstract：:Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...

journal_title：Molecular neurobiology

authors： Islam A,Kagawa Y,Miyazaki H,Shil SK,Umaru BA,Yasumoto Y,Yamamoto Y,Owada Y

更新日期：2019-08-01 00:00:00

abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...

journal_title：Molecular neurobiology

authors： Murphy M,Bartlett PF

更新日期：1993-07-01 00:00:00

abstract：:The use of statins for the prevention or treatment of different neurodegenerative diseases has generated considerable interest albeit with some controversy. Mechanisms of statin-induced neuroprotection are not well understood. Recently, we reported that simvastatin stimulated neuronal gene expression and protein level...

journal_title：Molecular neurobiology

authors： Butterick TA,Igbavboa U,Eckert GP,Sun GY,Weisman GA,Müller WE,Wood WG

更新日期：2010-06-01 00:00:00

abstract：:(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...

journal_title：Molecular neurobiology

authors： Zhang JC,Xu H,Yuan Y,Chen JY,Zhang YJ,Lin Y,Yuan SY

更新日期：2017-07-01 00:00:00

abstract：:Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...

journal_title：Molecular neurobiology

authors： Malan-Müller S,Hemmings SM,Seedat S

更新日期：2013-04-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...

journal_title：Molecular neurobiology

authors： Zieger E,Candiani S,Garbarino G,Croce JC,Schubert M

更新日期：2018-06-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...

journal_title：Molecular neurobiology

authors： Perianes-Cachero A,Lobo MVT,Hernández-Pinto AM,Busto R,Lasunción-Ripa MA,Arilla-Ferreiro E,Puebla-Jiménez L

更新日期：2020-02-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...

journal_title：Molecular neurobiology

authors： Sunwoo JS,Lee ST,Im W,Lee M,Byun JI,Jung KH,Park KI,Jung KY,Lee SK,Chu K,Kim M

更新日期：2017-03-01 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved with neurotransmitter release. Wit...

journal_title：Molecular neurobiology

authors： Tarr TB,Wipf P,Meriney SD

更新日期：2015-08-01 00:00:00

abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...

journal_title：Molecular neurobiology

authors： Wang H,Gao N,Li Z,Yang Z,Zhang T

更新日期：2016-04-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...

journal_title：Molecular neurobiology

authors： Nakka VP,Prakash-Babu P,Vemuganti R

更新日期：2016-01-01 00:00:00

abstract：:The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases. Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especia...

journal_title：Molecular neurobiology

authors： Schaffer S,Asseburg H,Kuntz S,Muller WE,Eckert GP

更新日期：2012-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of dementia with clinical symptoms that include deficits in memory, judgment, thinking, and behavior. Gangliosides are present on the outer surface of plasma membranes and are especially abundant in the nervous tissues of vertebrates. Ganglioside metabolism, especially ...

journal_title：Molecular neurobiology

authors： Ariga T

更新日期：2017-01-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes learning and memory deficits. Recently, it has been proved that the striatum is related to memory and learning ability. However, no previous study focused on the effect of Mn-induced learning and memory deficits on the striatum. This study aims ...

journal_title：Molecular neurobiology

authors： Song Q,Deng Y,Yang X,Bai Y,Xu B,Liu W,Zheng W,Wang C,Zhang M,Xu Z

更新日期：2016-12-01 00:00:00

abstract：:Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...

journal_title：Molecular neurobiology

authors： Eskandari-Sedighi G,Cortez LM,Yang J,Daude N,Shmeit K,Sim V,Westaway D

更新日期：2021-01-01 00:00:00

abstract：:Although statins, or hydroxymethylglutaryl coenzyme A (HMG-Co A) reductase inhibitors, are generally used to decrease levels of circulating cholesterol, they have also been reported to have neuroprotective effects through various mechanisms. However, recent results have indicated that they may be harmful in patients w...

journal_title：Molecular neurobiology

authors： Lee SH,Choi NY,Yu HJ,Park J,Choi H,Lee KY,Huh YM,Lee YJ,Koh SH

更新日期：2016-01-01 00:00:00

abstract：:Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active complex plays a fundamental role in brain development and functioning, but its deregulated activity has also been implicated in various neurodegenerative disorders, ...

journal_title：Molecular neurobiology

authors： Moncini S,Lunghi M,Valmadre A,Grasso M,Del Vescovo V,Riva P,Denti MA,Venturin M

更新日期：2017-08-01 00:00:00

abstract：:Once infected by HIV-1, microglia abundantly produce accessory protein Nef that enhances virus production and infectivity, but little is known about its intracellular compartmentalization, trafficking mode(s), and release from microglia. Here, we transfected immortalized human microglia with a plasmid encoding Nef tag...

journal_title：Molecular neurobiology

authors： Stenovec M,Lasič E,Dominkuš PP,Bobnar ST,Zorec R,Lenassi M,Kreft M

更新日期：2019-01-01 00:00:00

abstract：:Recently, we reported a correlation of scopolamine mediated decline in memory consolidation with increase in the expression of DNA methyltransferase 1 (DNMT1) and histone deacetylase 2 (HDAC2) in the mouse hippocampus. Memory consolidation is a protein synthesis-dependent process which involves the expression of synap...

journal_title：Molecular neurobiology

authors： Srivas S,Thakur MK

更新日期：2017-09-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of brain-derived neurotrophic factor (BDNF)-transfected bone marrow mesenchymal stem cells (BMSCs) on neural functional recovery and synaptophysin expression in rats with cerebral infarction (CI). A total of 120 healthy Sprague Dawley rats were randomly divided ...

journal_title：Molecular neurobiology

authors： Zhang Y,Qiu B,Wang J,Yao Y,Wang C,Liu J

更新日期：2017-07-01 00:00:00

abstract：:Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NS...

journal_title：Molecular neurobiology

authors： Wang X,Yu X,Xie C,Tan Z,Tian Q,Zhu D,Liu M,Guan Y

更新日期：2016-05-01 00:00:00

abstract：:Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...

journal_title：Molecular neurobiology

authors： Wang W,Wang F,Liu J,Zhao W,Zhao Q,He M,Qian BJ,Xu Y,Liu R,Liu SJ,Liu W,Liu J,Zhou XF,Wang TH

更新日期：2014-10-01 00:00:00

abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...

journal_title：Molecular neurobiology

authors： Vohra R,Kolko M

更新日期：2020-04-01 00:00:00

abstract：:Expression changes for long non-coding RNAs (lncRNAs) have been identified in adult glioblastoma multiforme (GBM) and in a mixture of adult and pediatric astrocytoma. Since adult and pediatric astrocytomas are molecularly different, the mixture of both could mask specific features in each. We determined the global exp...

journal_title：Molecular neurobiology

authors： Ruiz Esparza-Garrido R,Rodríguez-Corona JM,López-Aguilar JE,Rodríguez-Florido MA,Velázquez-Wong AC,Viedma-Rodríguez R,Salamanca-Gómez F,Velázquez-Flores MÁ

更新日期：2017-10-01 00:00:00

abstract：:Epilepsy is a common neurological disorder characterized by recurrent seizures. These seizures are due to abnormal excessive and synchronous neuronal activity in the brain caused by a disruption of the delicate balance between excitation and inhibition. Neuropeptides can contribute to such misbalance by modulating the...

journal_title：Molecular neurobiology

authors： Clynen E,Swijsen A,Raijmakers M,Hoogland G,Rigo JM

更新日期：2014-10-01 00:00:00

abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...

journal_title：Molecular neurobiology

authors： Yabuki Y,Takahata I,Matsuo K,Owada Y,Fukunaga K

更新日期：2018-04-01 00:00:00