Abstract：
:Alzheimer's disease (AD) is the most common type of dementia with clinical symptoms that include deficits in memory, judgment, thinking, and behavior. Gangliosides are present on the outer surface of plasma membranes and are especially abundant in the nervous tissues of vertebrates. Ganglioside metabolism, especially the cholinergic neuron-specific gangliosides, GQ1bα and GT1aα, is altered in mouse model of AD and patients with AD. Thus, alterations in ganglioside metabolism may participate in several events related to the pathogenesis of AD. Increased expressions of GT1aα may reflect cholinergic neurogenesis. Most changes in ganglioside metabolism occur in the specific brain areas and their lipid rafts. Targeting ganglioside metabolism in lipid rafts may represent an underexploited opportunity to design novel therapeutic strategies for AD.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Ariga Tdoi
10.1007/s12035-015-9641-0subject
Has Abstractpub_date
2017-01-01 00:00:00pages
623-638issue
1eissn
0893-7648issn
1559-1182pii
10.1007/s12035-015-9641-0journal_volume
54pub_type
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