Abstract:
:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system is now extensively considered as a potential therapeutic intervention for those diseases. The immune cells of the nervous system express Toll-like receptor 4 (TLR4) together with myeloid differentiation factor 2 (MD-2) to protect against the pathogens. Over the last 10 years, antagonists targeting the functional domains of MD-2 have become attractive pharmacological intervention strategies in pre-clinical studies into neuroinflammation and its associated brain pathologies. This review aims to summarize and discuss the roles of TLR4-MD-2 signaling pathway activation in various models of neuroinflammation. This review article also highlights the studies reporting the effect of MD-2 antagonists on neuroinflammation in in vitro and in vivo studies.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SCdoi
10.1007/s12035-020-02066-2subject
Has Abstractpub_date
2020-11-01 00:00:00pages
4825-4844issue
11eissn
0893-7648issn
1559-1182pii
10.1007/s12035-020-02066-2journal_volume
57pub_type
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