Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons.

abstract：:The induction of synthesis or release of endogenous neurotrophic factors in the brain by low-molecular-weight drugs could be a feasible alternative for the direct administration of neurotrophic factors for the treatment of central nervous system disorders. Recent data suggest that several drugs already in clinical use...

journal_title：Molecular neurobiology

authors： Castrén E

更新日期：2004-06-01 00:00:00

abstract：:Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anx...

journal_title：Molecular neurobiology

authors： Feng B,Liu JC,Zhang J,Ozaki K,Guo YY,Yi DH,Li XQ,Zhao MG

更新日期：2013-06-01 00:00:00

abstract：:The understanding of how pain is processed at each stage in the peripheral and central nervous system is the precondition to develop new therapies for the selective treatment of pain. In the periphery, ATP can be released from various cells as a consequence of tissue injury or visceral distension and may stimulate the...

journal_title：Molecular neurobiology

authors： Wirkner K,Sperlagh B,Illes P

更新日期：2007-10-01 00:00:00

abstract：:Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...

journal_title：Molecular neurobiology

authors： Rothan HA,Fang S,Mahesh M,Byrareddy SN

更新日期：2019-04-01 00:00:00

abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...

journal_title：Molecular neurobiology

authors： Lunardi N,Oklopcic A,Prillaman M,Erisir A,Jevtovic-Todorovic V

更新日期：2015-10-01 00:00:00

abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...

journal_title：Molecular neurobiology

authors： Liu S,Zhao Z,Guo Y,Shu H,Li C,Tang Y,Xing Y,Tao F

更新日期：2018-05-01 00:00:00

abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...

journal_title：Molecular neurobiology

authors： Slikker W Jr,Liu F,Rainosek SW,Patterson TA,Sadovova N,Hanig JP,Paule MG,Wang C

更新日期：2015-10-01 00:00:00

abstract：:The functions of chloride channels in preconditioning-induced cell protection remain unclear. In this report, we show that the volume-activated chloride channels play a key role in hydrogen peroxide (H2O2) preconditioning-induced cell protection in pheochromocytoma PC12 cells. The preconditioning with 100 μM H2O2 for ...

journal_title：Molecular neurobiology

authors： Zhu L,Zuo W,Yang H,Zhang H,Luo H,Ye D,Lin X,Mao J,Feng J,Chen L,Wang L

更新日期：2013-08-01 00:00:00

abstract：:Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule...

journal_title：Molecular neurobiology

authors： Mata A,Urrea L,Vilches S,Llorens F,Thüne K,Espinosa JC,Andréoletti O,Sevillano AM,Torres JM,Requena JR,Zerr I,Ferrer I,Gavín R,Del Río JA

更新日期：2017-10-01 00:00:00

abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...

journal_title：Molecular neurobiology

authors： Chiang WC,Kroeger H,Sakami S,Messah C,Yasumura D,Matthes MT,Coppinger JA,Palczewski K,LaVail MM,Lin JH

更新日期：2015-08-01 00:00:00

abstract：:Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression. A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects in a hippocampal neuronal cell line. The present study is an extension...

journal_title：Molecular neurobiology

authors： Freitas AE,Egea J,Buendia I,Gómez-Rangel V,Parada E,Navarro E,Casas AI,Wojnicz A,Ortiz JA,Cuadrado A,Ruiz-Nuño A,Rodrigues ALS,Lopez MG

更新日期：2016-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...

journal_title：Molecular neurobiology

authors： Xiang Q,Bi R,Xu M,Zhang DF,Tan L,Zhang C,Fang Y,Yao YG

更新日期：2017-09-01 00:00:00

abstract：:In the present study, we demonstrate that molecular chaperone Hsp70 and Hsc70 is essential for normal organization and development of ommatidial cells in Drosophila melanogaster eye. An exogenously expressed dominant negative mutant of Hsp70 (K71E) and Hsc70.4 (K71S and D206S) in an eye-specific manner resulted in eye...

journal_title：Molecular neurobiology

authors： Kumar A,Tiwari AK

更新日期：2018-05-01 00:00:00

abstract：:Neuronal plasticity can be defined as adaptive changes in structure and function of the nervous system, an obvious example of which is the capacity to remember and learn. Long-term potentiation and long-term depression are the experimental models of memory in the central nervous system (CNS), and have been frequently ...

journal_title：Molecular neurobiology

authors： Tokuda M,Hatase O

更新日期：1998-01-01 00:00:00

abstract：:Cerebrolysin is a peptide mixture able to ameliorate symptomatology and delay progression of neurological disorders such as Alzheimer's disease and dementia. The administration of this drug in humans presents several criticisms due to its short half-life, poor stability, and high doses needed to achieve the effect. Th...

journal_title：Molecular neurobiology

authors： Ruozi B,Belletti D,Sharma HS,Sharma A,Muresanu DF,Mössler H,Forni F,Vandelli MA,Tosi G

更新日期：2015-10-01 00:00:00

abstract：:Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxi...

journal_title：Molecular neurobiology

authors： Kupershmidt L,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2012-08-01 00:00:00

abstract：:The retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis...

journal_title：Molecular neurobiology

authors： Vohra R,Kolko M

更新日期：2020-04-01 00:00:00

abstract：:The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2...

journal_title：Molecular neurobiology

authors： Du N,Xu D,Hou X,Song X,Liu C,Chen Y,Wang Y,Li X

更新日期：2016-05-01 00:00:00

abstract：:The striatum is divided into two compartments, the striosomes and extrastriosomal matrix, which differ in several cytochemical markers, input-output connections, and time of neurogenesis. Since it is thought that limbic, reward-related information and executive aspects of behavioral information may be differentially p...

journal_title：Molecular neurobiology

authors： Miura M,Masuda M,Aosaki T

更新日期：2008-04-01 00:00:00

abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...

journal_title：Molecular neurobiology

authors： Ustyugov A,Shevtsova E,Bachurin S

更新日期：2015-10-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging gen...

journal_title：Molecular neurobiology

authors： Wu Z,Yang L,Wang Y

更新日期：2014-10-01 00:00:00

abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...

journal_title：Molecular neurobiology

authors： Boghdadi AG,Teo L,Bourne JA

更新日期：2018-03-01 00:00:00

abstract：:Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...

journal_title：Molecular neurobiology

authors： Malenka RC

更新日期：1991-01-01 00:00:00

abstract：:Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...

journal_title：Molecular neurobiology

authors： Matthys A,Haegeman G,Van Craenenbroeck K,Vanhoenacker P

更新日期：2011-06-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...

journal_title：Molecular neurobiology

authors： Schlief ML,Gitlin JD

更新日期：2006-04-01 00:00:00

abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

journal_title：Molecular neurobiology

authors： Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

更新日期：2017-04-01 00:00:00

abstract：:α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in Parkinson's disease (PD). The aggregation of α-synuclein is believed to be a critical event in the disease process. α-Synuclein is characterized by a remarkable conformational plasticity, adopting different conforma...

journal_title：Molecular neurobiology

authors： Berrocal R,Vasquez V,Rao Krs S,Gadad BS,Rao KS

更新日期：2015-01-01 00:00:00

abstract：:B-50 (GAP-43) is an axonal, plasma membrane-associated protein involved in growth cone morphology and function. We have conducted immunocytochemical, electron microscopic, and time-lapse experiments to visualize morphological consequences of local accumulations of B-50 at the plasma membrane of B-50-transfected PC-B2 ...

journal_title：Molecular neurobiology

authors： Aarts LH,Verkade P,Schrama LH,Oestreicher AB,Gispen WH,Schotman P

更新日期：1999-08-01 00:00:00

abstract：:Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...

journal_title：Molecular neurobiology

authors： Sun L,Zhang Z,Xu J,Xu G,Liu X

更新日期：2016-08-01 00:00:00