Abstract:
:Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxidant-iron chelator moiety of the 8-hydroxyquinoline derivative of the iron chelator, VK28. In the present short overview, we describe the neuroprotective and the neurorestorative activity of M30, acting against multiple brain targets, including regulation on amyloid β, neurogenesis, and activation of hypoxia inducible factor signaling pathways. The diverse pharmacological properties and several pathological targets of M30 make this drug potential valuable for therapeutic strategy of Alzheimer's-like neuropathology and aging.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Kupershmidt L,Amit T,Bar-Am O,Weinreb O,Youdim MBdoi
10.1007/s12035-012-8304-7subject
Has Abstractpub_date
2012-08-01 00:00:00pages
217-20issue
1eissn
0893-7648issn
1559-1182journal_volume
46pub_type
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