Abstract：
:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this process indicate that noradrenaline induces the production of the chemokine CCL2 in astrocytes. While CCL2 can protect neurons against certain injuries, its overproduction has also proven to be harmful and to prevent noradrenaline neuroprotective effects. Therefore, in this study, we analyze if the modifications caused to astrocytes by an excessive production of CCL2 may alter their response to noradrenaline. Using primary cultures of rat cortical astrocytes, we observed that CCL2 enhances the production of beta 2 adrenergic receptors in these cells. While this potentiates noradrenaline signaling through cAMP, the activation of the transcription factor CREB is inhibited by CCL2. Furthermore, although CCL2 potentiates noradrenaline induction of glycogenolysis, this does not translate into an augmented release of lactate, one of the processes through which astrocytes help support neurons. Additionally, other neuroprotective actions of noradrenaline, such as the production of brain derived neurotrophic factor and the inhibition of the inducible nitric oxide synthase in astrocytes were modified by CCL2. These data suggest that some of the central nervous system alterations related to CCL2 could be due to its effects on adrenergic receptors and its interference with noradrenaline signaling.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Gutiérrez IL,González-Prieto M,García-Bueno B,Caso JR,Feinstein DL,Madrigal JLMdoi
10.1007/s12035-018-0960-9subject
Has Abstractpub_date
2018-10-01 00:00:00pages
7872-7885issue
10eissn
0893-7648issn
1559-1182pii
10.1007/s12035-018-0960-9journal_volume
55pub_type
杂志文章abstract：:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析
doi：10.1007/s12035-016-9823-4
更新日期：2017-05-01 00:00:00
abstract：:α-Synuclein aggregation contributes to the Parkinson's disease (PD) pathology in multiple ways-the two most important being the activation of neuroinflammation and mitochondrial dysfunction. Our recent studies have shown the beneficial effects of a heat shock protein (HSP) inducer, carbenoxolone (Cbx), in reducing the...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8769-7
更新日期：2015-02-01 00:00:00
abstract：:The Shadoo protein (Sho) exhibits homology to the hydrophobic region of the cellular isoform of prion protein (PrPC). As prion-infected brains gradually accumulate infectivity-associated isoforms of prion protein (PrPSc), levels of mature endogenous Sho become reduced. To study the regulatory effect of the proteostati...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1623-1
更新日期：2019-11-01 00:00:00
abstract：:Modulation of αCaMKII expression and phosphorylation is a feature shared by drugs of abuse with different mechanisms of action. Accordingly, we investigated whether αCaMKII expression and activation could be altered by self-administration of ketamine, a non-competitive antagonist of the NMDA glutamate receptor, with a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0772-3
更新日期：2018-07-01 00:00:00
abstract：:Once infected by HIV-1, microglia abundantly produce accessory protein Nef that enhances virus production and infectivity, but little is known about its intracellular compartmentalization, trafficking mode(s), and release from microglia. Here, we transfected immortalized human microglia with a plasmid encoding Nef tag...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1072-2
更新日期：2019-01-01 00:00:00
abstract：:Major depression is a serious side effect of interferon-α (IFN-α), which is used in the therapy of hepatitis C virus (HCV) infection. Due to the lack of reproducible animal models, the mechanisms underlying IFN-α-related depression are largely unknown. We herein established a mouse model, in which murine IFN-α (250 IU...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8861-z
更新日期：2015-08-01 00:00:00
abstract：:PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral de...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02099-7
更新日期：2020-12-01 00:00:00
abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9465-y
更新日期：2016-10-01 00:00:00
abstract：:Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01849-6
更新日期：2020-04-01 00:00:00
abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9928-9
更新日期：2017-03-01 00:00:00
abstract：:The aim of this work was to study the effect of glucagon-like peptide-2 (GLP-2) on the cyclic guanosine monophosphate (cGMP) signalling pathway and whether insulin or epidermal growth factor (EGF) might modulate the effects of GLP-2. GLP-2 produced a dose-dependent decrease in intracellular sodium nitroprusside-induce...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8298-1
更新日期：2012-10-01 00:00:00
abstract：:The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0171-1
更新日期：2017-10-01 00:00:00
abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9587-2
更新日期：2017-01-01 00:00:00
abstract：:Neurodegenerative foldopathies are characterized by aberrant folding of diseased modified proteins, which are major constituents of the intracellular and extracellular lesions. These lesions correlate with the cognitive and/or motor impairment seen in these diseases. The majority of the disease modified proteins in ne...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8440-8
更新日期：2013-12-01 00:00:00
abstract：:c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, are involved in the regulation of several physiological functions in mammals and act as mediators of apoptosis, obesity, and memory storage in the brain, including the processes of neuronal de- and regeneration. JNK subf...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9522-6
更新日期：2016-11-01 00:00:00
abstract：:We have previously shown that inadequate dystrophin in cortical neurons in mdx mice is associated with age-dependent dyshomeostasis of resting intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), elevated reactive oxygen species (ROS) production, increase in neuronal damage and cognitive deficit. In this study, we assessed ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1018-8
更新日期：2018-11-01 00:00:00
abstract：:Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been eluci...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9382-0
更新日期：2016-09-01 00:00:00
abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9935-x
更新日期：2017-07-01 00:00:00
abstract：:Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD ly...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0105-y
更新日期：2017-09-01 00:00:00
abstract：:There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0795-9
更新日期：2018-07-01 00:00:00
abstract：:Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke. However, the results are inconsistent. Thus, we conducted this meta-analysis to evaluate risk effect of chromosome 4q25 variants on ischemic stroke. We performed the liter...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析
doi：10.1007/s12035-015-9332-x
更新日期：2016-08-01 00:00:00
abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...
journal_title：Molecular neurobiology
pub_type： 已发布勘误
doi：10.1007/s12035-018-1095-8
更新日期：2018-10-01 00:00:00
abstract：:Enriched environment (EE) protects the retina from adult rats against ischemia/reperfusion (I/R) injury; however, how the components of EE contribute to the recovery after retinal ischemic damage remains unclear. We analyzed the contribution of social, cognitive, and visual stimulation on functional and histological a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01715-5
更新日期：2020-01-01 00:00:00
abstract：:Bisphenol A (BPA) is a ubiquitous compound emerging as a possible toxicant during embryonic development. Human embryonic stem cell (hESC) promises a valuable model for evaluating the effects of environmental chemicals on human prenatal development. In our study, 1 μM BPA were applied to hESC-derived embryoid bodies (h...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9898-y
更新日期：2017-07-01 00:00:00
abstract：:Insulin receptors in the brain are found in high densities in the hippocampus, a region that is fundamentally involved in the acquisition, consolidation, and recollection of new information. Using the intranasal method, which effectively bypasses the blood-brain barrier to deliver and target insulin directly from the ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-011-8229-6
更新日期：2012-08-01 00:00:00
abstract：:The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0857-z
更新日期：2018-08-01 00:00:00
abstract：:There is considerable attention being given to the association of Alzheimer's disease and cholesterol homeostasis. To that end, some have suggested that elevated cholesterol levels are a risk factor for Alzheimer's disease. If elevated cholesterol is a risk factor for Alzheimer's disease, then it would be expected tha...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:31:1-3:185
更新日期：2005-01-01 00:00:00
abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8881-8
更新日期：2015-08-01 00:00:00
abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0144-4
更新日期：2017-10-01 00:00:00
abstract：:Topoisomerase I (topo I) is a nuclear enzyme which participates in most DNA transactions. It was shown to be inhibited in depolarized neurons by poly adenosine diphosphate (ADP)-ribosylation of the enzyme protein. We demonstrated previously an age and sex dependent topo I activity and enzyme protein level in the vario...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-008-8044-x
更新日期：2008-12-01 00:00:00
