Abstract：
:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was recently shown in the spinal cord of human sporadic ALS patients and in the SOD1(G93A) mouse model for ALS. In the present study, we investigated the neuroprotective and anti-inflammatory effects of 17β-estradiol (E2) treatment in pre-symptomatic and symptomatic male SOD1(G93A) mice. Symptomatic mice with E2 substitution exhibited improved motor performance correlating with an increased survival of motoneurons in the lumbar spinal cord. Expression of NLRP3 inflammasome proteins and levels of activated caspase 1 and mature interleukin 1 beta were significantly reduced in SOD1(G93A) mice supplemented with E2.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Heitzer M,Kaiser S,Kanagaratnam M,Zendedel A,Hartmann P,Beyer C,Johann Sdoi
10.1007/s12035-016-0322-4subject
Has Abstractpub_date
2017-12-01 00:00:00pages
8429-8443issue
10eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-0322-4journal_volume
54pub_type
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