Abstract:
:Due to the prevalence of neuromuscular disorders such as amyotrophic lateral sclerosis and spinal muscular atrophy in modern societies, defining new and efficient strategies for the treatment of these two neurodegenerative diseases has become a vital and still unfulfilled urge. Several lines of experimental evidence have emphasized the benefits of regular exercise training in mouse models for these affections in terms of life span increase and improvement of both motor capacities and motoneuron survival. Identifying molecules that could mimic the neuroprotective effects of exercise represents a promising way to find novel therapies. Some of the effects of exercise are caused by the overproduction of circulating neurotrophic factors, such as IGF-I, whereas others may be due to modifications of the intrinsic properties of the motoneurons within the spinal cord. The causal relationship that links these potential effects of exercise training and the improvement of motor capacity and life span expectancy is consequently discussed.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Charbonnier Fdoi
10.1007/s12035-007-0027-9subject
Has Abstractpub_date
2007-06-01 00:00:00pages
217-23issue
3eissn
0893-7648issn
1559-1182pii
MN:35:3:217journal_volume
35pub_type
杂志文章,评审abstract::Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elev...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
abstract::Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NS...
journal_title:Molecular neurobiology
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更新日期:2017-07-01 00:00:00
abstract::Heat shock proteins (Hsps) are highly conserved proteins that are induced in response to various physiological and environmental stressors. HspB1 (Hsp27) is a prominent member of the small Hsps family and is strongly induced during the stress response. Notably, HspB1 has powerful neuroprotective effects, increasing th...
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Molecular neurobiology
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更新日期:2015-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
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更新日期:1993-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-02-01 00:00:00
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journal_title:Molecular neurobiology
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12035-016-9836-z
更新日期:2017-05-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9693-9
更新日期:2016-11-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9754-0
更新日期:2017-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0519-1
更新日期:2018-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12035-020-02123-w
更新日期:2021-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02780664
更新日期:1994-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01687-6
更新日期:2019-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02755590
更新日期:1996-06-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8788-4
更新日期:2015-02-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-010-8127-3
更新日期:2010-08-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-013-8620-6
更新日期:2014-06-01 00:00:00
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12035-020-01897-3
更新日期:2020-06-01 00:00:00