Abstract:
:Tourette syndrome (TS) is a childhood-onset neurological disorder. To date, accurate TS diagnosis remains challenging due to its varied clinical expressions and dependency on qualitative description of symptoms. Therefore, identifying accurate and objective neuroimaging biomarkers may help improve early TS diagnosis. As resting-state functional MRI (rs-fMRI) has been demonstrated as a promising neuroimaging tool for TS diagnosis, previous rs-fMRI studies on TS revealed functional connectivity (FC) changes in a few local brain networks or circuits. However, no study explored the disrupted topological organization of whole-brain FC networks in TS children. Meanwhile, very few studies have examined brain functional networks using machine-learning methods for diagnostics. In this study, we construct individual whole-brain, ROI-level FC networks for 29 drug-naive TS children and 37 healthy children. Then, we use graph theory analysis to investigate the topological disruptions between groups. The identified disrupted regions in FC networks not only involved the sensorimotor association regions but also the visual, default-mode and language areas, all highly related to TS. Furthermore, we propose a novel classification framework based on similarity network fusion (SNF) algorithm, to both diagnose an individual subject and explore the discriminative power of FC network topological properties in distinguishing between TS children and controls. We achieved a high accuracy of 88.79%, and the involved discriminative regions for classification were also highly related to TS. Together, both the disrupted topological properties between groups and the discriminative topological features for classification may be considered as comprehensive and helpful neuroimaging biomarkers for assisting the clinical TS diagnosis.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wen H,Liu Y,Rekik I,Wang S,Chen Z,Zhang J,Zhang Y,Peng Y,He Hdoi
10.1007/s12035-017-0519-1subject
Has Abstractpub_date
2018-04-01 00:00:00pages
3251-3269issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-017-0519-1journal_volume
55pub_type
杂志文章abstract::Olfactory perception and learning play a vital role in the animal's entire life for habituation and survival. Insulin and insulin receptor signaling is well known to modulate the olfactory function and is also involved in the regulation of neurogenesis. A very high density of insulin receptors is present in the olfact...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02185-w
更新日期:2020-10-29 00:00:00
abstract::Expression changes for long non-coding RNAs (lncRNAs) have been identified in adult glioblastoma multiforme (GBM) and in a mixture of adult and pediatric astrocytoma. Since adult and pediatric astrocytomas are molecularly different, the mixture of both could mask specific features in each. We determined the global exp...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0123-9
更新日期:2017-10-01 00:00:00
abstract::Cognitive control processes play an essential role not only in controlling actions but also in guiding attentional selection processes. Interestingly, these processes are strongly affected by organizational principles of the cerebral cortex and related functional asymmetries, but the neurobiological foundations are el...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0485-7
更新日期:2018-03-01 00:00:00
abstract::Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes learning and memory deficits. Recently, it has been proved that the striatum is related to memory and learning ability. However, no previous study focused on the effect of Mn-induced learning and memory deficits on the striatum. This study aims ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9602-7
更新日期:2016-12-01 00:00:00
abstract::Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0695-z
更新日期:2018-06-01 00:00:00
abstract::Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in autophagy/m...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0859-x
更新日期:2018-08-01 00:00:00
abstract::Bisphenol A (BPA) is a ubiquitous compound emerging as a possible toxicant during embryonic development. Human embryonic stem cell (hESC) promises a valuable model for evaluating the effects of environmental chemicals on human prenatal development. In our study, 1 μM BPA were applied to hESC-derived embryoid bodies (h...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9898-y
更新日期:2017-07-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1211-9
更新日期:2019-04-01 00:00:00
abstract::Microwave-induced learning and memory deficits in animal models have been gaining attention in recent years, largely because of increasing public concerns on growing environmental influences. The data from our group and others have showed that the injury of mitochondria, the major source of cellular adenosine triphosp...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8667-z
更新日期:2014-12-01 00:00:00
abstract::The neuroprotective potential of 3,3'-diindolylmethane (DIM), which is a selective aryl hydrocarbon receptor modulator, has recently been shown in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation. However, there are no data concerning the protective capacity and mechanisms ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9471-0
更新日期:2016-10-01 00:00:00
abstract::There is accumulating evidence on the use of N-acetylcysteine (NAC) in the treatment of patients with neuropsychiatric disorders. As a multi-target drug and a glutathione precursor, NAC is a promising molecule in the management of stress-related disorders, for which there is an expanding field of research investigatin...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1165-y
更新日期:2019-02-01 00:00:00
abstract::PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellula...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02242-4
更新日期:2021-01-07 00:00:00
abstract::Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-015-9280-5
更新日期:2016-05-01 00:00:00
abstract::Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that c...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1341-0
更新日期:2019-05-01 00:00:00
abstract::Sphingosine-1-phosphate (S1P) produced by sphingosine kinases (SPHK1 and SPHK2) is a signaling molecule involved in cell proliferation and formation of cellular junctions. In this study, we characterized the retinas of Sphk1 knockout (KO) mice by electron microscopy and immunocytochemistry. We also tested cultured Mül...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1599-x
更新日期:2019-10-01 00:00:00
abstract::Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the applicatio...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9275-2
更新日期:2016-05-01 00:00:00
abstract::The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved in mediating fast excitatory synaptic transmission. Recent studies in both heterologous expression systems and cultured neurons have shown that the AMPA recept...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:32:3:237
更新日期:2005-12-01 00:00:00
abstract::A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9541-3
更新日期:2016-11-01 00:00:00
abstract::Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in st...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-9707-7
更新日期:2017-03-01 00:00:00
abstract::Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the endoplasmic reticulum of all cells. All three RyR isoforms, RyR1-3, are expressed in the brain, with RyR2 predominating. RyRs are localized within the soma, axons, dendritic spines, and presynaptic terminals of neurons. RyRs are highly ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-0375-4
更新日期:2018-02-01 00:00:00
abstract::Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1506-5
更新日期:2019-09-01 00:00:00
abstract::Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chemical environment of the airways and lungs. Subtypes are heterogenous in their responsiveness to stimuli, phenotype, and developmental origin, but they collectively serve to regulate normal ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01782-8
更新日期:2020-02-01 00:00:00
abstract::The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0171-1
更新日期:2017-10-01 00:00:00
abstract::The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:32:2:157
更新日期:2005-10-01 00:00:00
abstract::The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-010-8127-3
更新日期:2010-08-01 00:00:00
abstract::Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8365-7
更新日期:2013-04-01 00:00:00
abstract::The study of neurite growth in tissue culture has been a productive way to identify substances that may control the behavior of axons in vivo. Molecules that promote the outgrowth of neurites include nerve growth factor, laminin, fibronectin, and a protease inhibitor derived from glia. Evidence that these molecules ma...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02936609
更新日期:1987-10-01 00:00:00
abstract::For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:29:2:117
更新日期:2004-04-01 00:00:00
abstract::Recent progress in molecular biology has markedly expanded our knowledge of the molecular mechanism behind the proliferation and differentiation processes of Schwann cells, the myelin-forming cells in peripheral nervous systems. Intracellular signaling molecules participate in integrating various stimuli from cytokine...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/mn:33:1:051
更新日期:2006-02-01 00:00:00
abstract::Accumulating evidences indicate that endogenous modulators of excitatory synapses in the mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed, glutamatergic and adenosinergic neurotransmissions were recently highlighted as potential targets for developing innovative anxiolytic drugs. A...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9660-x
更新日期:2017-01-01 00:00:00