bHLH genes and retinal cell fate specification.

abstract：:Among five members of the K+-dependent Na+/Ca2+ exchanger (NCKX) family (NCKX1-5), only NCKX2 is highly expressed in mouse brain. NCKX2 in plasma membranes mediates cytosolic calcium excretion through electrogenic exchange of 4 Na+ for 1 Ca2+ and 1 K+. Here, we observed significantly decreased levels of NCKX2 protein ...

journal_title：Molecular neurobiology

authors： Moriguchi S,Kita S,Yabuki Y,Inagaki R,Izumi H,Sasaki Y,Tagashira H,Horie K,Takeda J,Iwamoto T,Fukunaga K

更新日期：2018-05-01 00:00:00

abstract：:The considerable roles of transcription factors, and the associated signaling molecules that activate them, are well deciphered in the context of various biological processes. One of the important transcription factors, the transforming growth factor-β (TGF-β) pathway, has a profound role in neuronal cell survival-a p...

journal_title：Molecular neurobiology

authors： Haque R,Nazir A

更新日期：2016-01-01 00:00:00

abstract：:The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible...

journal_title：Molecular neurobiology

authors： Shen Y,Liu XL,Yang XL

更新日期：2006-12-01 00:00:00

abstract：:Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury...

journal_title：Molecular neurobiology

authors： Shin T,Ahn M,Moon C,Kim S,Sim KB

更新日期：2013-06-01 00:00:00

abstract：:Peripheral nerve injury requires optimal conditions in both macro-environment and microenvironment for promotion of axonal regeneration. However, most repair strategies of traumatic peripheral nerve injury often lead to dissatisfying results in clinical outcome. Though various strategies have been carried out to impro...

journal_title：Molecular neurobiology

authors： Bucan V,Vaslaitis D,Peck CT,Strauß S,Vogt PM,Radtke C

更新日期：2019-03-01 00:00:00

abstract：:Oxidative stress is a key component of the pathological cascade in subarachnoid hemorrhage (SAH). Fucoxanthin (Fx) possesses a strong antioxidant property and has shown neuroprotective effects in acute brain injuries such as ischemic stroke and traumatic brain injury. Here, we investigated the beneficial effects of Fx...

journal_title：Molecular neurobiology

authors： Zhang XS,Lu Y,Tao T,Wang H,Liu GJ,Liu XZ,Liu C,Xia DY,Hang CH,Li W

更新日期：2020-12-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been shown to have useful properties for cell therapy and have been proposed for treatment of neurodegenerative diseases, including Parkinson's disease. However, the mechanisms involved in recovering dopaminergic neurons are not clear. The present study aims to evaluate the pathwa...

journal_title：Molecular neurobiology

authors： Parga JA,García-Garrote M,Martínez S,Raya Á,Labandeira-García JL,Rodríguez-Pallares J

更新日期：2018-06-01 00:00:00

abstract：:Recent genome-wide association studies have identified two variants rs10033464 and rs2200733 on chromosome 4q25, significantly associated with ischemic stroke risk. We conducted this study to investigate whether these two variants were associated with age at onset and prognosis of ischemic stroke in a Chinese populati...

journal_title：Molecular neurobiology

authors： Sun L,Tian L,Xu J,Zhang Z,Liu X

更新日期：2017-07-01 00:00:00

abstract：:Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NS...

journal_title：Molecular neurobiology

authors： Wang X,Yu X,Xie C,Tan Z,Tian Q,Zhu D,Liu M,Guan Y

更新日期：2016-05-01 00:00:00

abstract：:Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could be associated with the pathophysiology of depression. This study investigated the markers of microglia and astrocyte activation as well as indoleamine 2,3-dioxygenase (IDO) expression in developmental programming after early lif...

journal_title：Molecular neurobiology

authors： Réus GZ,Silva RH,de Moura AB,Presa JF,Abelaira HM,Abatti M,Vieira A,Pescador B,Michels M,Ignácio ZM,Dal-Pizzol F,Quevedo J

更新日期：2019-02-01 00:00:00

abstract：:Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been eluci...

journal_title：Molecular neurobiology

authors： Dong J,Lei X,Wang Y,Wang Y,Song H,Li M,Min H,Yu Y,Xi Q,Teng W,Chen J

更新日期：2016-09-01 00:00:00

abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

journal_title：Molecular neurobiology

authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

更新日期：2017-03-01 00:00:00

abstract：:Establishment of appropriate neuronal connections during development and regeneration requires the extension of processes that must then grow in the correct direction, find and recognize their targets, and make synapses with them. During development, embryonic neurons gradually establish central and peripheral connect...

journal_title：Molecular neurobiology

authors： Kuffler DP

更新日期：1994-08-01 00:00:00

abstract：:Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xT...

journal_title：Molecular neurobiology

authors： Corpas R,Griñán-Ferré C,Rodríguez-Farré E,Pallàs M,Sanfeliu C

更新日期：2019-02-01 00:00:00

abstract：:Physiological mechanisms of neuronal information processing have been shaped during evolution by a continual interplay between organisms and their sensory surroundings. Thus, when asking for the functional significance of such mechanisms, the natural conditions under which they operate must be considered. This has bee...

journal_title：Molecular neurobiology

authors： Kurtz R,Egelhaaf M

更新日期：2003-02-01 00:00:00

abstract：:The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathoge...

journal_title：Molecular neurobiology

authors： Chelluboina B,Nalamolu KR,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

更新日期：2018-02-01 00:00:00

abstract：:Beginning in the early stages of Alzheimer's disease (AD), the hippocampus reduces its functional connections to other cortical regions due to synaptic depletion. However, little is known regarding connectivity abnormalities within the hippocampus. Here, we describe rostral-caudal hippocampal convergence (rcHC), a met...

journal_title：Molecular neurobiology

authors： Therriault J,Wang S,Mathotaarachchi S,Pascoal TA,Parent M,Beaudry T,Shin M,Al B,Kang MS,Ng KP,Dansereau C,Park MTM,Fonov V,Carbonell F,Zimmer E,Chakravarty MM,Bellec P,Gauthier S,Rosa-Neto P,Alzheimer’s Disease Neur

更新日期：2019-12-01 00:00:00

abstract：:In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-responsive element-binding protein (CREB) activation suggests that this transcription factor plays a critical role in integrating different inputs and mediating appropriate neuronal responses. The nature of this transcriptional re...

journal_title：Molecular neurobiology

authors： Barco A,Marie H

更新日期：2011-12-01 00:00:00

abstract：:Although photobiomodulation therapy (PBM) has been applied clinically for the treatment of pain and inflammation, wound healing, sports and soft tissue injuries, as well as to repair injured spinal cords and peripheral nerves, it remains unclear which molecular substrates (receptor) are implicated in the cellular mech...

journal_title：Molecular neurobiology

authors： Neves LMS,Gonçalves ECD,Cavalli J,Vieira G,Laurindo LR,Simões RR,Coelho IS,Santos ARS,Marcolino AM,Cola M,Dutra RC

更新日期：2018-07-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Exposure to organic forms of mercury has the theoretical capacity to generate a range of immune abnormalities coupled with chronic nitro-oxidative stress seen in children with autism spectrum disorder (ASD). The paper discusses possible mechanisms explaining the neurotoxic effects of mercury and possible associations ...

journal_title：Molecular neurobiology

authors： Morris G,Puri BK,Frye RE,Maes M

更新日期：2018-06-01 00:00:00

abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...

journal_title：Molecular neurobiology

authors： Oliveira SR,Figueiredo-Pereira C,Duarte CB,Vieira HLA

更新日期：2019-05-01 00:00:00

abstract：:PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral de...

journal_title：Molecular neurobiology

authors： Serratto GM,Pizzi E,Murru L,Mazzoleni S,Pelucchi S,Marcello E,Mazzanti M,Passafaro M,Bassani S

更新日期：2020-12-01 00:00:00

abstract：:There is variety of stem cell sources but problems in ethical issues, contamination, and normal karyotype cause many limitations in obtaining and using these cells. The cells in Wharton's jelly region of umbilical cord are abundant and available stem cells with low immunological incompatibility, which could be conside...

journal_title：Molecular neurobiology

authors： Bahrami N,Bayat M,Mohamadnia A,Khakbiz M,Yazdankhah M,Ai J,Ebrahimi-Barough S

更新日期：2017-09-01 00:00:00

abstract：:Rotenone, a pesticide, causes neurotoxicity via the mitochondrial complex-I inhibition. The present study was conducted to evaluate the role of endoplasmic reticulum (ER) stress in rotenone-induced neuronal death. Cell viability, cytotoxicity, reactive oxygen species (ROS) generation, nitrite level, mitochondrial memb...

journal_title：Molecular neurobiology

authors： Goswami P,Gupta S,Biswas J,Joshi N,Swarnkar S,Nath C,Singh S

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...

journal_title：Molecular neurobiology

authors： Geng X,Li F,Yip J,Peng C,Elmadhoun O,Shen J,Ji X,Ding Y

更新日期：2017-12-01 00:00:00

abstract：:There is robust evidence that major depression (MDD) is accompanied by a low-grade activation of the immune-inflammatory response system, which is involved in the pathophysiology of this disorder. It is also becoming apparent that glia cells are in reciprocal communication with neurons, orchestrate various neuromodula...

journal_title：Molecular neurobiology

authors： Rudzki L,Maes M

更新日期：2020-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common forms of dementia among elder people, which is a progressive neurodegenerative disease that results from a chronic loss of cognitive activities. It has been observed that AD is multifactorial, hence diverse pharmacological targets that could be followed for the treatm...

journal_title：Molecular neurobiology

authors： Uddin MS,Al Mamun A,Kabir MT,Ashraf GM,Bin-Jumah MN,Abdel-Daim MM

更新日期：2021-01-01 00:00:00

abstract：:Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...

journal_title：Molecular neurobiology

authors： Mele M,Morelli S,Fazzari G,Avolio E,Alò R,Piscioneri A,De Bartolo L,Facciolo RM,Canonaco M

更新日期：2017-11-01 00:00:00

abstract：:Autism spectrum disorders (ASD) comprise a complex of neurodevelopmental disorders caused by a variety of genetic defects and characterized by alterations in social communication and repetitive behavior. Since the mechanisms leading to early neuronal degeneration remain elusive, we chose to examine the properties of N...

journal_title：Molecular neurobiology

authors： Grasselli C,Carbone A,Panelli P,Giambra V,Bossi M,Mazzoccoli G,De Filippis L

更新日期：2020-03-01 00:00:00