Abstract：
:Physiological mechanisms of neuronal information processing have been shaped during evolution by a continual interplay between organisms and their sensory surroundings. Thus, when asking for the functional significance of such mechanisms, the natural conditions under which they operate must be considered. This has been done successfully in several studies that employ sensory stimulation under in vivo conditions. These studies address the question of how physiological mechanisms within neurons are properly adjusted to the characteristics of natural stimuli and to the demands imposed on the system being studied. Results from diverse animal models show how neurons exploit natural stimulus statistics efficiently by utilizing specific filtering capacities. Mechanisms that allow neurons to adapt to the currently relevant range from an often immense stimulus spectrum are outlined, and examples are provided that suggest that information transfer between neurons is shaped by the system-specific computational tasks in the behavioral context.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Kurtz R,Egelhaaf Mdoi
10.1385/MN:27:1:13subject
Has Abstractpub_date
2003-02-01 00:00:00pages
13-32issue
1eissn
0893-7648issn
1559-1182pii
MN:27:1:13journal_volume
27pub_type
杂志文章,评审abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9246-7
更新日期：2015-10-01 00:00:00
abstract：:Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could be associated with the pathophysiology of depression. This study investigated the markers of microglia and astrocyte activation as well as indoleamine 2,3-dioxygenase (IDO) expression in developmental programming after early lif...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1161-2
更新日期：2019-02-01 00:00:00
abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9587-2
更新日期：2017-01-01 00:00:00
abstract：:Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-010-8121-9
更新日期：2010-06-01 00:00:00
abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-0002-5
更新日期：2007-08-01 00:00:00
abstract：:The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and adminis...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0723-z
更新日期：2018-01-01 00:00:00
abstract：:Many neurotransmitters and hormones activate receptors that are known to be coupled to their effectors by GTP-binding regulatory proteins, G proteins. Activation of many of these same receptors elicits arachidonate release and metabolism. During the past few years, novel experimental techniques have revealed that in m...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02935629
更新日期：1989-10-01 00:00:00
abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9928-9
更新日期：2017-03-01 00:00:00
abstract：:The human KCTD13 gene is located within the 16p11.2 locus and copy number variants of this locus are associated with a high risk for neuropsychiatric diseases including autism spectrum disorder and schizophrenia. Studies in zebrafish point to a role of KCTD13 in proliferation of neural precursor cells which may contri...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01727-1
更新日期：2020-02-01 00:00:00
abstract：:α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in Parkinson's disease (PD). The aggregation of α-synuclein is believed to be a critical event in the disease process. α-Synuclein is characterized by a remarkable conformational plasticity, adopting different conforma...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8818-2
更新日期：2015-01-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9518-2
更新日期：2016-11-01 00:00:00
abstract：:Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0559-6
更新日期：2018-04-01 00:00:00
abstract：:Fear is crucial for survival, whereas hypermnesia of fear can be detrimental. Inhibition of the Rac GTPase is recently reported to impair the forgetting of initially acquired memory in Drosophila. Here, we investigated whether inhibition of Rac1 activity in rat hippocampus could contribute to the hypermnesia of contex...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9093-6
更新日期：2016-03-01 00:00:00
abstract：:Involvement of membrane mineralocorticoid (MC) and glucocorticoid (GC) receptors in synaptic Zn2+ dynamics remains unclear. Here, we tested whether synaptic plasticity is affected by rapid intracellular Zn2+ dysregulation via membrane MC and GC receptor activation, in comparison with intracellular Ca2+ dysregulation. ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1159-9
更新日期：2019-02-01 00:00:00
abstract：:Exposure to organic forms of mercury has the theoretical capacity to generate a range of immune abnormalities coupled with chronic nitro-oxidative stress seen in children with autism spectrum disorder (ASD). The paper discusses possible mechanisms explaining the neurotoxic effects of mercury and possible associations ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-017-0692-2
更新日期：2018-06-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-008-8023-2
更新日期：2008-04-01 00:00:00
abstract：:It has recently been reported that the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway regulates neuronal differentiation of neural stem cells (NSCs) derived from rats or mice and is essential for the self-renewal of human embryonic stem cells (hESCs). However, the roles of ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9325-9
更新日期：2016-08-01 00:00:00
abstract：:Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1424-y
更新日期：2019-07-01 00:00:00
abstract：:Structural rearrangements of chromosome 10 are frequently observed in glioblastoma multiforme and over 80 % of tumour samples archived in the catalogue of somatic mutations in cancer database had gene copy number loss for PI4K2A which encodes phosphatidylinositol 4-kinase type IIalpha. PI4K2A loss of heterozygosity mi...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9034-9
更新日期：2016-01-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02108-9
更新日期：2021-01-01 00:00:00
abstract：:The study of neurite growth in tissue culture has been a productive way to identify substances that may control the behavior of axons in vivo. Molecules that promote the outgrowth of neurites include nerve growth factor, laminin, fibronectin, and a protease inhibitor derived from glia. Evidence that these molecules ma...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02936609
更新日期：1987-10-01 00:00:00
abstract：:Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression. A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects in a hippocampal neuronal cell line. The present study is an extension...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9182-6
更新日期：2016-07-01 00:00:00
abstract：:Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0524-4
更新日期：2018-03-01 00:00:00
abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...
journal_title：Molecular neurobiology
pub_type： 已发布勘误
doi：10.1007/s12035-018-1095-8
更新日期：2018-10-01 00:00:00
abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-0947-6
更新日期：2018-10-01 00:00:00
abstract：:There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0795-9
更新日期：2018-07-01 00:00:00
abstract：:Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin re...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0275-7
更新日期：2017-12-01 00:00:00
abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9073-2
更新日期：2016-04-01 00:00:00
abstract：:The human natural killer-1 (HNK-1), 3-sulfonated glucuronic acid, is a glycoepitope marker of cell adhesion that participates in cell-cell and cell-extracellular matrix interactions and in neurite growth. Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzhei...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9644-x
更新日期：2017-01-01 00:00:00
abstract：:Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-1263-x
更新日期：2019-04-01 00:00:00
