Chromosome 4q25 Variants and Age at Onset of Ischemic Stroke.

abstract：:Structural rearrangements of chromosome 10 are frequently observed in glioblastoma multiforme and over 80 % of tumour samples archived in the catalogue of somatic mutations in cancer database had gene copy number loss for PI4K2A which encodes phosphatidylinositol 4-kinase type IIalpha. PI4K2A loss of heterozygosity mi...

journal_title：Molecular neurobiology

authors： Waugh MG

更新日期：2016-01-01 00:00:00

abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...

journal_title：Molecular neurobiology

authors： Hochgräfe K,Mandelkow EM

更新日期：2013-06-01 00:00:00

abstract：:We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized...

journal_title：Molecular neurobiology

authors： Steg G,Johnels B

更新日期：1994-08-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active complex plays a fundamental role in brain development and functioning, but its deregulated activity has also been implicated in various neurodegenerative disorders, ...

journal_title：Molecular neurobiology

authors： Moncini S,Lunghi M,Valmadre A,Grasso M,Del Vescovo V,Riva P,Denti MA,Venturin M

更新日期：2017-08-01 00:00:00

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:Olfactory dysfunction is deeply associated with quality of human life in the aging population. Olfactory dysfunction is an occasional presymptomatic sign of neuroimmunological multiple sclerosis, neuromyelitis optica, and systemic lupus erythematosus. Olfaction is initially processed by olfactory receptor cells that c...

journal_title：Molecular neurobiology

authors： Shin T,Kim J,Ahn M,Moon C

更新日期：2019-05-01 00:00:00

abstract：:The neurotoxicity of levodopa (L-DOPA) on neural stem cells (NSCs) and treatment strategies to protect NSCs from this neurotoxicity remain to be elucidated. Recently, an active form of vitamin D3 has been reported to display neuroprotective properties. Therefore, we investigated the protective effect of 1,25-dyhydroxy...

journal_title：Molecular neurobiology

authors： Jang W,Park HH,Lee KY,Lee YJ,Kim HT,Koh SH

更新日期：2015-04-01 00:00:00

abstract：:Neonatal hypoxic-ischemic (HI) injury still remains an important issue as it is a major cause of neonatal death and neurological dysfunctions. Currently, there are no well-established treatments to reduce brain damage and its long-term sequel in infants. Recently, reported data show that histone deacetylase inhibitors...

journal_title：Molecular neurobiology

authors： Ziemka-Nalecz M,Jaworska J,Sypecka J,Polowy R,Filipkowski RK,Zalewska T

更新日期：2017-09-01 00:00:00

abstract：:This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...

journal_title：Molecular neurobiology

authors： Wu W,Guan Y,Xu K,Fu XJ,Lei XF,Lei LJ,Zhang ZQ,Cheng Y,Li YQ

更新日期：2016-05-01 00:00:00

abstract：:Recent evidence suggests that hypoxia preconditioning can alter the microRNA (miRNA) profile of extracellular vesicles (EVs) and has better neuroprotective effects when enriched miRs are delivered to recipients. However, the roles of exosomal miRNAs in regulating ischaemia-reperfusion (IR)-induced pain hypersensitivit...

journal_title：Molecular neurobiology

authors： Wang H,Chen FS,Zhang ZL,Zhou HX,Ma H,Li XQ

更新日期：2021-02-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a regulator of MMP-9 expression and cells migration. However, the mechanisms underlying thrombin-induced MMP-9 expression in rat brain astrocytes (RBA-1 cel...

journal_title：Molecular neurobiology

authors： Lin CC,Lee IT,Wu WB,Liu CJ,Hsieh HL,Hsiao LD,Yang CC,Yang CM

更新日期：2013-12-01 00:00:00

abstract：:Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintain...

journal_title：Molecular neurobiology

authors： Zhang N,Yu X,Xie J,Xu H

更新日期：2021-01-28 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...

journal_title：Molecular neurobiology

authors： Liou CJ,Yang CM,Lee TH,Liu PS,Hsieh HL

更新日期：2019-01-01 00:00:00

abstract：:Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. Both activation and inhibition of SIRT1 were previously shown to ameliorate neuropathological mechanisms in Huntington's disease (HD), a neurodegenerative disease...

journal_title：Molecular neurobiology

authors： Naia L,Rosenstock TR,Oliveira AM,Oliveira-Sousa SI,Caldeira GL,Carmo C,Laço MN,Hayden MR,Oliveira CR,Rego AC

更新日期：2017-09-01 00:00:00

abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

journal_title：Molecular neurobiology

authors： Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

更新日期：2018-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder. A defining hallmark of the AD brain is the presence of intraneuronal neurofibrillary tangles (NFTs) which are made up of abnormally modified tau, with aberrant phosphorylation being the most studied posttranslational modification (PTM)...

journal_title：Molecular neurobiology

authors： Guha S,Johnson GVW,Nehrke K

更新日期：2020-12-01 00:00:00

abstract：:Previous studies have postulated that neuroinflammation can induce two different types of reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may be protective. Specifically, prokineticin 2 (PK2) has been shown to regulate neuron-astrocyte signaling mechanism by promoting an alternative...

journal_title：Molecular neurobiology

authors： Ma M,Li H,Wu J,Zhang Y,Shen H,Li X,Wang Z,Chen G

更新日期：2020-09-01 00:00:00

abstract：:Abnormal hippocampal neurogenesis is a prominent feature of temporal lobe epilepsy (TLE) models, which is thought to contribute to abnormal brain activity. Stromal cell-derived factor-1 (SDF-1) and its specific receptor CXCR4 play important roles in adult neurogenesis. We investigated whether treatment with the CXCR4 ...

journal_title：Molecular neurobiology

authors： Song C,Xu W,Zhang X,Wang S,Zhu G,Xiao T,Zhao M,Zhao C

更新日期：2016-04-01 00:00:00

abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...

journal_title：Molecular neurobiology

authors： Yabuki Y,Takahata I,Matsuo K,Owada Y,Fukunaga K

更新日期：2018-04-01 00:00:00

abstract：:Hyperpalatable diets (HP) impair brain metabolism, and regular physical exercise has an apparent opposite effect. Here, we combined a prior long-term exposure to HP diet followed by physical exercise and evaluated the impact on some neuroenergetic components and on cognitive performance. We assessed the extracellular ...

journal_title：Molecular neurobiology

authors： Portela LV,Brochier AW,Haas CB,de Carvalho AK,Gnoato JA,Zimmer ER,Kalinine E,Pellerin L,Muller AP

更新日期：2017-10-01 00:00:00

abstract：:Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...

journal_title：Molecular neurobiology

authors： Malan-Müller S,Hemmings SM,Seedat S

更新日期：2013-04-01 00:00:00

abstract：:The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the development...

journal_title：Molecular neurobiology

authors： Sun Y,Cheng X,Zhang L,Hu J,Chen Y,Zhan L,Gao Z

更新日期：2017-03-01 00:00:00

abstract：:PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellula...

journal_title：Molecular neurobiology

authors： Mincheva-Tasheva S,Nieto Guil AF,Homan CC,Gecz J,Thomas PQ

更新日期：2021-01-07 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...

journal_title：Molecular neurobiology

authors： Mingazov ER,Khakimova GR,Kozina EA,Medvedev AE,Buneeva OA,Bazyan AS,Ugrumov MV

更新日期：2018-04-01 00:00:00

abstract：:Oxidative stress is a key component of the pathological cascade in subarachnoid hemorrhage (SAH). Fucoxanthin (Fx) possesses a strong antioxidant property and has shown neuroprotective effects in acute brain injuries such as ischemic stroke and traumatic brain injury. Here, we investigated the beneficial effects of Fx...

journal_title：Molecular neurobiology

authors： Zhang XS,Lu Y,Tao T,Wang H,Liu GJ,Liu XZ,Liu C,Xia DY,Hang CH,Li W

更新日期：2020-12-01 00:00:00

abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...

journal_title：Molecular neurobiology

authors： Lunardi N,Oklopcic A,Prillaman M,Erisir A,Jevtovic-Todorovic V

更新日期：2015-10-01 00:00:00

abstract：:For the epigenetic characterization of neuromyelitis optica (NMO), we determined whether messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in subjects with and without NMO. lncRNA and mRNA expression profiles of NMO patients and healthy controls were generated by using microarray an...

journal_title：Molecular neurobiology

authors： Xu J,Zhang F,Gao C,Ma X,Peng X,Kong D,Hao J

更新日期：2017-04-01 00:00:00

abstract：:Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin ...

journal_title：Molecular neurobiology

authors： Tomé-Carneiro J,Carmen Crespo M,Burgos-Ramos E,Tomas-Zapico C,García-Serrano A,Castro-Gómez P,Venero C,Pereda-Pérez I,Baliyan S,Valencia A,Fontecha J,Dávalos A,Visioli F

更新日期：2018-09-01 00:00:00