Abstract：
:For the epigenetic characterization of neuromyelitis optica (NMO), we determined whether messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in subjects with and without NMO. lncRNA and mRNA expression profiles of NMO patients and healthy controls were generated by using microarray analysis. For comparison, the differentially expressed mRNA functions were annotated by using gene ontology (GO) and pathway analyses. The microarray revealed that 1310 lncRNAs and 743 mRNAs differed in NMO patients from those in healthy controls. Pathway analysis then demonstrated that IL23-mediated signaling events, interferon gamma signaling, natural killer (NK)-κB signaling pathway, chemokine receptors that bind chemokines, GPCR ligand binding, and metabolic disorders of biological oxidation enzyme pathways play important roles in NMO. Several GO terms including cytokine stimulus, response to cytokine, immune response, cytokine-mediated signaling pathway, and response to chemical cytokine activity were enriched in gene lists, suggesting a potential correlation with NMO. Co-expression network analysis indicated that 183 lncRNAs and 458 mRNAs were included in the co-expression network. Our present study showed that these differentially expressed mRNAs and lncRNAs may play important roles in NMO and could provide basic information for new biomarkers or treatment targets to alleviate NMO.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Xu J,Zhang F,Gao C,Ma X,Peng X,Kong D,Hao Jdoi
10.1007/s12035-016-9754-0subject
Has Abstractpub_date
2017-04-01 00:00:00pages
2201-2208issue
3eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9754-0journal_volume
54pub_type
杂志文章abstract：:Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0695-z
更新日期：2018-06-01 00:00:00
abstract：:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9280-5
更新日期：2016-05-01 00:00:00
abstract：:Cyclin-dependent kinase 5 regulatory subunit 1 (CDK5R1) encodes p35, the main activatory subunit of cyclin-dependent kinase 5 (CDK5). The p35/CDK5 active complex plays a fundamental role in brain development and functioning, but its deregulated activity has also been implicated in various neurodegenerative disorders, ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0002-4
更新日期：2017-08-01 00:00:00
abstract：:Defect in brain microperfusion is increasingly recognized as an antecedent event to Alzheimer's disease (AD) and ischemia. Nevertheless, studies on the role of impaired microperfusion as a pathological trigger to neuroinflammation, Aβ deposition as well as blood-brain barrier (BBB) disruption, and the etiological link...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0904-4
更新日期：2018-10-01 00:00:00
abstract：:AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neuronal loss. Growing evidences indicate that dysregulation of regulato...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8704-y
更新日期：2014-12-01 00:00:00
abstract：:Despite the increasing evidence of eye abnormalities, the effects of prenatal exposure to cocaine on the visual system are still poorly understood. This study was aimed at analyzing the qualitative and quantitative organization of the retinal photoreceptor cells (PR) and outer nuclear layer (ONL) after prenatal exposu...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02740686
更新日期：1995-08-01 00:00:00
abstract：:There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0795-9
更新日期：2018-07-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circR...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-01878-6
更新日期：2020-05-01 00:00:00
abstract：:Recent evidence suggests that blockade of normal excitation in the immature nervous system may have profound effects on neuronal survival during the period of natural cell death. Cell loss following depression of electrical activity in the central nervous system (CNS) may explain the neuropsychiatric deficits in human...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:22:1-3:041
更新日期：2000-08-01 00:00:00
abstract：:The benefits of programmed cell death by apoptosis are the safe and efficient clearance of damaged, infected, or surplus cells, primarily mediated by tissue-resident macrophages or tissue-infiltrating blood monocytes that differentiate into macrophages. Microglial cells are macrophages of the brain parenchyma, importa...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-010-8127-3
更新日期：2010-08-01 00:00:00
abstract：:Tonic inhibition mediated by ambient levels of GABA that activate extrasynaptic GABAA receptors emerges as an essential factor that tunes neuronal network excitability in vitro and shapes behavioral responses in vivo. To address the role of neuromodulatory transmitter systems on this type of inhibition, we employed pa...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0984-1
更新日期：2018-11-01 00:00:00
abstract：:The ubiquitin-proteasome system (UPS) is the main intracellular pathway for modulated protein turnover, playing an important role in the maintenance of cellular homeostasis. It also exerts a protein quality control through degradation of oxidized, mutant, denatured, or misfolded proteins and is involved in many biolog...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8391-5
更新日期：2013-04-01 00:00:00
abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0962-7
更新日期：2018-10-01 00:00:00
abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8379-1
更新日期：2013-06-01 00:00:00
abstract：:The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD) remain largely unclear. In the present study, we were aimed to identify the potential key molecules involved in spatial memory impairment in a triple transgenic (3xTg-AD) mouse model of AD. By employing two-dimensional fluorescence di...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9959-2
更新日期：2017-07-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12035-015-9271-6
更新日期：2016-05-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8667-z
更新日期：2014-12-01 00:00:00
abstract：:Thyroid hormone plays an important role in central nervous system (CNS) development, including the myelination of variable axonal calibers. It is well-established that thyroid hormone is required for the terminal differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes by inducing ra...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-016-0013-1
更新日期：2016-11-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8578-4
更新日期：2014-04-01 00:00:00
abstract：:Light triggers a sequence of events that damage photoreceptor cells within the superior central portion of the retina, resulting in apoptotic cell death. This damage is mediated by energy absorbed by rhodopsin and the intermediates of the rhodopsin-bleaching process. Furthermore, inhibition of the visual cycle and the...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:28:2:111
更新日期：2003-10-01 00:00:00
abstract：:Ryanodine receptors (RyRs) are intracellular calcium-release channels found on the endoplasmic reticulum of all cells. All three RyR isoforms, RyR1-3, are expressed in the brain, with RyR2 predominating. RyRs are localized within the soma, axons, dendritic spines, and presynaptic terminals of neurons. RyRs are highly ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-016-0375-4
更新日期：2018-02-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0280-x
更新日期：2017-12-01 00:00:00
abstract：:Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-1263-x
更新日期：2019-04-01 00:00:00
abstract：:CRMP1, a member of the collapsin response mediator protein family (CRMPs), was reported to regulate axon outgrowth in Sema3A signaling pathways via interactions with its co-receptor protein neuropilin-1 and plexin-As through the Fyn-cyclin-dependent kinase 5 (CDK5) cascade and the sequential phosphorylation of CRMP1 b...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9049-2
更新日期：2016-03-01 00:00:00
abstract：:Olfactory dysfunction is a recognized risk factor for the pathogenesis of Alzheimer's disease (AD), while the mechanisms are still not clear. Here, we applied bilateral olfactory bulbectomy (OBX), an olfactory deprivation surgery to cause permanent anosmia, in human tau-overexpressed mice (htau mice) to investigate ch...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9007-z
更新日期：2016-01-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8304-7
更新日期：2012-08-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8398-6
更新日期：2013-06-01 00:00:00
abstract：:Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis (ALS), while wild-type TDP-43 is a pathological hallmark of patients with sporadic ALS and frontotemporal lobar degeneration (FTLD). Various in vitro and in vivo studies have also demonstrated toxicity ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8427-5
更新日期：2013-08-01 00:00:00
abstract：:The 22q11.2 deletion has been identified as a risk factor for multiple neurodevelopmental disorders. Behavioral and cognitive impairments are common among carriers of the 22q11.2 deletion. Parvalbumin expressing (PV+) interneurons provide perisomatic inhibition of excitatory neuronal circuits through GABAA receptors, ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02067-1
更新日期：2020-12-01 00:00:00
abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-0002-5
更新日期：2007-08-01 00:00:00
