Abstract:
:Recent evidence suggests that blockade of normal excitation in the immature nervous system may have profound effects on neuronal survival during the period of natural cell death. Cell loss following depression of electrical activity in the central nervous system (CNS) may explain the neuropsychiatric deficits in humans exposed to alcohol or other CNS depressants during development. Thus, understanding the role of electrical activity in the survival of young neurons is an important goal of modern basic and clinical neuroscience. Here we review the evidence from in vivo and in vitro model systems that electrical activity participates in promoting neuronal survival. We discuss the potential role of moderate elevations of intracellular calcium in promoting survival, and we address the possible ways in which activity and conventional trophic factors may interact.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Mennerick S,Zorumski CFdoi
10.1385/MN:22:1-3:041subject
Has Abstractpub_date
2000-08-01 00:00:00pages
41-54issue
1-3eissn
0893-7648issn
1559-1182pii
MN:22:1-3:041journal_volume
22pub_type
杂志文章,评审abstract::Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy or early childhood. While several hypotheses have been proposed to explain the occurrence of IA, the neurobiological and molecular bases for this accelerated forgetting phenomenon remain elusive. Using hippocampus-depende...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1119-4
更新日期:2019-02-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF), in addition to its neurotrophic action, also possesses antioxidant activities. However, the underlying mechanisms remain to be fully defined. Sestrin2 is a stress-responsive gene implicated in the cellular defense against oxidative stress. Currently, the potential functions of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9357-1
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9927-x
更新日期:2017-07-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1387-z
更新日期:2019-06-01 00:00:00
abstract::Fenpropathrin is one of the widely used pyrethroids in agriculture and household and also reported to have neurotoxic effects in rodent models. In our Parkinson's disease (PD) clinic, there was a unique patient with a history of daily exposure to fenpropathrin for 6 months prior to developing Parkinsonian symptoms pro...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9057-2
更新日期:2016-03-01 00:00:00
abstract::Several studies support a protective effect of vitamin D on multiple sclerosis and experimental allergic encephalomyelitis (EAE), but the mechanisms of these favorable effects are unclear. Our study demonstrates that sphingosine 1-phosphate (S1P) is upregulated in the serum and spinal cords of EAE rats, but that vitam...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8686-9
更新日期:2014-12-01 00:00:00
abstract::YKL-40 is the most highly expressed gene in glioblastoma compared with normal brain tissues. Previous studies assessing the association between YKL-40 and survival in glioblastoma patients reported varying magnitude of estimates. The objective of this meta-analysis was to determine the prognostic value of YKL-40 in gl...
journal_title:Molecular neurobiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-07-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/BF02740686
更新日期:1995-08-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8917-0
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-0969-0
更新日期:2018-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:27:1:13
更新日期:2003-02-01 00:00:00
abstract::Involvement of membrane mineralocorticoid (MC) and glucocorticoid (GC) receptors in synaptic Zn2+ dynamics remains unclear. Here, we tested whether synaptic plasticity is affected by rapid intracellular Zn2+ dysregulation via membrane MC and GC receptor activation, in comparison with intracellular Ca2+ dysregulation. ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1159-9
更新日期:2019-02-01 00:00:00
abstract::Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01701-x
更新日期:2020-01-01 00:00:00
abstract::Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a severe deficiency in the activity of the branched-chain α-keto acid dehydrogenase complex, leading to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine. Infections have a significant role in precipitating ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8618-0
更新日期:2014-10-01 00:00:00
abstract::Sonic hedgehog (Shh) has been found to regulate the angiogenic growth factor such as VEGF, Ang-1, and Ang-2 during ischemic insults, but the underlying mechanism is not fully understood. In this study, we employed oxygen-glucose deprivation (OGD) in astrocytes to mimic the ischemia in vitro. We found that OGD could in...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-013-8395-9
更新日期:2013-06-01 00:00:00
abstract::Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH,...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9242-y
更新日期:2016-07-01 00:00:00
abstract::Due to the prevalence of neuromuscular disorders such as amyotrophic lateral sclerosis and spinal muscular atrophy in modern societies, defining new and efficient strategies for the treatment of these two neurodegenerative diseases has become a vital and still unfulfilled urge. Several lines of experimental evidence h...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-007-0027-9
更新日期:2007-06-01 00:00:00
abstract::The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1596-0
更新日期:2019-11-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0171-1
更新日期:2017-10-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8828-0
更新日期:2015-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8847-x
更新日期:2015-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s12035-020-02041-x
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9102-9
更新日期:2016-04-01 00:00:00
abstract::Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0144-4
更新日期:2017-10-01 00:00:00
abstract::This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9226-y
更新日期:2016-05-01 00:00:00
abstract::Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental cha...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02261-1
更新日期:2021-01-08 00:00:00
abstract::The aim of this study was to examine if nicotine was able to improve cognition deficits in a mouse model of chronic mild stress. Twenty-four male C57BL/6 mice were divided into three groups: control, stress, and stress with nicotine treatment. The animal model was established by combining chronic unpredictable mild st...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0012-2
更新日期:2017-08-01 00:00:00
abstract::In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...
journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
abstract::Amyloid-β oligomers (AβOs) toxicity causes mitochondrial dysfunction, leading to synaptic failure in Alzheimer's disease (AD). Considering presynaptic high energy demand and tight Ca2+ regulation, impairment of mitochondrial function can lead to deteriorated neural activity and cell death. In this study, an AD mouse m...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02064-4
更新日期:2020-11-01 00:00:00
abstract::Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-010-8121-9
更新日期:2010-06-01 00:00:00