Infantile Amnesia Is Related to Developmental Immaturity of the Maintenance Mechanisms for Long-Term Potentiation.

abstract：:There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk....

journal_title：Molecular neurobiology

authors： Mullin AP,Gokhale A,Larimore J,Faundez V

更新日期：2011-08-01 00:00:00

abstract：:Vimentin is an intermediate filament (also known as nanofilament) protein expressed in several cell types of the central nervous system, including astrocytes and neural stem/progenitor cells. Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibr...

journal_title：Molecular neurobiology

authors： Chen M,Puschmann TB,Marasek P,Inagaki M,Pekna M,Wilhelmsson U,Pekny M

更新日期：2018-07-01 00:00:00

abstract：:Neuronal plasticity can be defined as adaptive changes in structure and function of the nervous system, an obvious example of which is the capacity to remember and learn. Long-term potentiation and long-term depression are the experimental models of memory in the central nervous system (CNS), and have been frequently ...

journal_title：Molecular neurobiology

authors： Tokuda M,Hatase O

更新日期：1998-01-01 00:00:00

abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...

journal_title：Molecular neurobiology

authors： Ustyugov A,Shevtsova E,Bachurin S

更新日期：2015-10-01 00:00:00

abstract：:Atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their...

journal_title：Molecular neurobiology

authors： Cai T,Groves AK

更新日期：2015-12-01 00:00:00

abstract：:The chronic stage multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), remains refractory to current treatments. This refractory nature may be due to the fact that current treatments are primarily immunomodulatory, which prevent further demyelination but lack the capacity...

journal_title：Molecular neurobiology

authors： Li X,Zhang Y,Yan Y,Ciric B,Ma CG,Chin J,Curtis M,Rostami A,Zhang GX

更新日期：2017-08-01 00:00:00

abstract：:The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic...

journal_title：Molecular neurobiology

authors： Yan RT,Ma W,Liang L,Wang SZ

更新日期：2005-10-01 00:00:00

abstract：:Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elev...

journal_title：Molecular neurobiology

authors： Nelson TJ,Alkon DL

更新日期：1991-01-01 00:00:00

abstract：:Hippocampus-dependent memories, such as social recognition (SRM), are modulated by neurogenesis. However, the precise role of newborn neurons in social memory processing is still unknown. We showed previously that 1 week of enriched environment (EE) is sufficient to increase neurogenesis in the hippocampus (HIP) and t...

journal_title：Molecular neurobiology

authors： Pereira-Caixeta AR,Guarnieri LO,Pena RR,Dias TL,Pereira GS

更新日期：2017-07-01 00:00:00

abstract：:A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis of infections, and interrogation of vaccine response. We hypothesized that there is an immunosignature specific...

journal_title：Molecular neurobiology

authors： Günther OP,Gardy JL,Stafford P,Fluge Ø,Mella O,Tang P,Miller RR,Parker SM,Johnston SA,Patrick DM

更新日期：2019-06-01 00:00:00

abstract：:While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...

journal_title：Molecular neurobiology

authors： Otero A,Bolea R,Hedman C,Fernández-Borges N,Marín B,López-Pérez Ó,Barrio T,Eraña H,Sánchez-Martín MA,Monzón M,Badiola JJ,Castilla J

更新日期：2018-07-01 00:00:00

abstract：:Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the physiological mechanisms are not fully understood. Senescence-accelerated prone mouse (SAMP8) models were conducted under metabolic stress conditions by feeding HF for 15 weeks, and the preventive effect of resveratrol was...

journal_title：Molecular neurobiology

authors： Palomera-Avalos V,Griñán-Ferré C,Puigoriol-Ilamola D,Camins A,Sanfeliu C,Canudas AM,Pallàs M

更新日期：2017-04-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...

journal_title：Molecular neurobiology

authors： Schlief ML,Gitlin JD

更新日期：2006-04-01 00:00:00

abstract：:Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects o...

journal_title：Molecular neurobiology

authors： Henn L,Zanta NC,Girardi CEN,Suchecki D

更新日期：2020-10-15 00:00:00

abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

journal_title：Molecular neurobiology

authors： Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

更新日期：2020-11-01 00:00:00

abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...

journal_title：Molecular neurobiology

authors： Oksdath M,Guil AFN,Grassi D,Sosa LJ,Quiroga S

更新日期：2017-10-01 00:00:00

abstract：:Cerebrolysin is a peptide mixture able to ameliorate symptomatology and delay progression of neurological disorders such as Alzheimer's disease and dementia. The administration of this drug in humans presents several criticisms due to its short half-life, poor stability, and high doses needed to achieve the effect. Th...

journal_title：Molecular neurobiology

authors： Ruozi B,Belletti D,Sharma HS,Sharma A,Muresanu DF,Mössler H,Forni F,Vandelli MA,Tosi G

更新日期：2015-10-01 00:00:00

abstract：:We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized...

journal_title：Molecular neurobiology

authors： Steg G,Johnels B

更新日期：1994-08-01 00:00:00

abstract：:Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal dea...

journal_title：Molecular neurobiology

authors： Wu X,Walker CL,Lu Q,Wu W,Eddelman DB,Parish JM,Xu XM

更新日期：2017-11-01 00:00:00

abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...

journal_title：Molecular neurobiology

authors： Oliveira SR,Figueiredo-Pereira C,Duarte CB,Vieira HLA

更新日期：2019-05-01 00:00:00

abstract：:Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals i...

journal_title：Molecular neurobiology

authors： Zhou Y,Yang T,Gong Y,Li W,Chen Y,Li J,Wang M,Yin X,Hu B,Lu Z

更新日期：2017-05-01 00:00:00

abstract：:The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD) remain largely unclear. In the present study, we were aimed to identify the potential key molecules involved in spatial memory impairment in a triple transgenic (3xTg-AD) mouse model of AD. By employing two-dimensional fluorescence di...

journal_title：Molecular neurobiology

authors： Ying M,Sui X,Zhang Y,Sun Q,Qu Z,Luo X,Chang RC,Ni J,Liu J,Yang X

更新日期：2017-07-01 00:00:00

abstract：:Germline and somatic mutations in key genes of the mammalian target of rapamycin (mTOR) pathway have been identified in seizure-associated disorders. mTOR mutations lead to aberrant activation of mTOR signaling, and, although affected neurons are critical for epileptogenesis, the role of mTOR activation in glial cells...

journal_title：Molecular neurobiology

authors： Wang X,Sha L,Sun N,Shen Y,Xu Q

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have postulated that neuroinflammation can induce two different types of reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may be protective. Specifically, prokineticin 2 (PK2) has been shown to regulate neuron-astrocyte signaling mechanism by promoting an alternative...

journal_title：Molecular neurobiology

authors： Ma M,Li H,Wu J,Zhang Y,Shen H,Li X,Wang Z,Chen G

更新日期：2020-09-01 00:00:00

abstract：:α-Synuclein (α-syn) has been recognized to induce neuroinflammation and to disturb nerve repair process in Parkinson's disease. However, the potential mechanisms underlying α-syn-induced impairment of adult neurogenesis remain unclear. In the present study, A53T mutant α--synuclein transgenic (A53Ttg/tg) mice, caspase...

journal_title：Molecular neurobiology

authors： Fan Z,Lu M,Qiao C,Zhou Y,Ding JH,Hu G

更新日期：2016-12-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...

journal_title：Molecular neurobiology

authors： Kira J

更新日期：1994-04-01 00:00:00

abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...

journal_title：Molecular neurobiology

authors： Johnson AM,Sugo E,Barreto D,Hiew CC,Lawson JA,Connolly AM,Somerville E,Hasic E,Bye AM,Cunningham AM

更新日期：2016-10-01 00:00:00

abstract：:Prion diseases are transmissible neurodegenerative disorders of humans and animals, which are characterized by the aggregation of abnormal prion protein (PrPSc) in the central nervous system. Although several small compounds that bind to normal PrP (PrPC) have been shown to inhibit structural conversion of the protein...

journal_title：Molecular neurobiology

authors： Miyazaki Y,Ishikawa T,Kamatari YO,Nakagaki T,Takatsuki H,Ishibashi D,Kuwata K,Nishida N,Atarashi R

更新日期：2019-01-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Her...

journal_title：Molecular neurobiology

authors： Lieberknecht V,Junqueira SC,Cunha MP,Barbosa TA,de Souza LF,Coelho IS,Santos AR,Rodrigues AL,Dafré AL,Dutra RC

更新日期：2017-03-01 00:00:00