Abstract：
:Tissues within the central nervous system (CNS) have generally been regarded as immunologically privileged. However, in recent decades, it has been shown that immune reactions in the CNS continuously occur via various types of inflammation following autoimmune diseases and mechanical insults such as spinal cord injury (SCI). Among the various inflammatory cells associated with CNS disease, activated macrophages are classically known to induce detrimental consequences that are mediated by the secretion of pro-inflammatory molecules. Alternatively activated macrophages have recently been shown to modulate various types of CNS inflammation, including SCI. This review summarizes the potential roles of alternatively activated macrophages in the course of CNS inflammation in rodent SCI models.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Shin T,Ahn M,Moon C,Kim S,Sim KBdoi
10.1007/s12035-013-8398-6subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1011-9issue
3eissn
0893-7648issn
1559-1182journal_volume
47pub_type
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