Thrombin mediates migration of rat brain astrocytes via PLC, Ca²⁺, CaMKII, PKCα, and AP-1-dependent matrix metalloproteinase-9 expression.

abstract：:Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...

journal_title：Molecular neurobiology

authors： Taha AY,Blanchard HC,Cheon Y,Ramadan E,Chen M,Chang L,Rapoport SI

更新日期：2017-08-01 00:00:00

abstract：:The present investigation is an expansion of previous studies which all share a basic experimental protocol of a porcine-induced cardiac arrest (CA) of 12 min followed by 8 min of cardiopulmonary resuscitation (CPR), different experimental treatments (immediate as well as postponed induced mild hypothermia and adminis...

journal_title：Molecular neurobiology

authors： Wiklund L,Patnaik R,Sharma A,Miclescu A,Sharma HS

更新日期：2018-01-01 00:00:00

abstract：:Morphine as an opioid is an important drug in the treatment of moderate to severe pain. Several stress factors via generation of nitric oxide (NO) and oxidative stress (OS) are responsible for the adverse effects of morphine-induced analgesia, addiction, and antinociceptive tolerance, including altered Ca2+ concentrat...

journal_title：Molecular neurobiology

authors： Osmanlıoğlu HÖ,Yıldırım MK,Akyuva Y,Yıldızhan K,Nazıroğlu M

更新日期：2020-08-01 00:00:00

abstract：:Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal dea...

journal_title：Molecular neurobiology

authors： Wu X,Walker CL,Lu Q,Wu W,Eddelman DB,Parish JM,Xu XM

更新日期：2017-11-01 00:00:00

abstract：:Structural rearrangements of chromosome 10 are frequently observed in glioblastoma multiforme and over 80 % of tumour samples archived in the catalogue of somatic mutations in cancer database had gene copy number loss for PI4K2A which encodes phosphatidylinositol 4-kinase type IIalpha. PI4K2A loss of heterozygosity mi...

journal_title：Molecular neurobiology

authors： Waugh MG

更新日期：2016-01-01 00:00:00

abstract：:Prion replication results from the autocatalytic templated assisted conversion of the host-encoded prion protein PrPC into misfolded, polydisperse PrPSc conformers. Structurally distinct PrPSc conformers can give rise to multiple prion strains. Within and between prion strains, the biological activity (replicative eff...

journal_title：Molecular neurobiology

authors： Igel-Egalon A,Laferrière F,Tixador P,Moudjou M,Herzog L,Reine F,Torres JM,Laude H,Rezaei H,Béringue V

更新日期：2020-06-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...

journal_title：Molecular neurobiology

authors： Kira J

更新日期：1994-04-01 00:00:00

abstract：:PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellula...

journal_title：Molecular neurobiology

authors： Mincheva-Tasheva S,Nieto Guil AF,Homan CC,Gecz J,Thomas PQ

更新日期：2021-01-07 00:00:00

abstract：:Recently, deregulated microRNA (miRNA) expression contributes to the development and progression of human glioblastoma. The aim of the present study was to evaluate the level of miR-154 and Wnt5a in glioblastoma tissues and cells. We further investigated the molecular mechanisms of miR-154 and Wnt5a in glioblastoma ce...

journal_title：Molecular neurobiology

authors： Zhao D,Wang R,Fang J,Ji X,Li J,Chen X,Sun G,Wang Z,Liu W,Wang Y,Cheng G,Zhen H,Sun C,Fei Z

更新日期：2017-05-01 00:00:00

abstract：:Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...

journal_title：Molecular neurobiology

authors： Zhang M,Gong JX,Wang JL,Jiang MY,Li L,Hu YY,Qi J,Zhang LY,Zhao H,Cui X,Xian XH,Li WB

更新日期：2017-01-01 00:00:00

abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...

journal_title：Molecular neurobiology

authors： Oksdath M,Guil AFN,Grassi D,Sosa LJ,Quiroga S

更新日期：2017-10-01 00:00:00

abstract：:Tonic inhibition mediated by ambient levels of GABA that activate extrasynaptic GABAA receptors emerges as an essential factor that tunes neuronal network excitability in vitro and shapes behavioral responses in vivo. To address the role of neuromodulatory transmitter systems on this type of inhibition, we employed pa...

journal_title：Molecular neurobiology

authors： Meis S,Endres T,Munsch T,Lessmann V

更新日期：2018-11-01 00:00:00

abstract：:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...

journal_title：Molecular neurobiology

authors： Kruk-Slomka M,Banaszkiewicz I,Slomka T,Biala G

更新日期：2019-11-01 00:00:00

abstract：:Neonatal hypoxic-ischemic (HI) injury still remains an important issue as it is a major cause of neonatal death and neurological dysfunctions. Currently, there are no well-established treatments to reduce brain damage and its long-term sequel in infants. Recently, reported data show that histone deacetylase inhibitors...

journal_title：Molecular neurobiology

authors： Ziemka-Nalecz M,Jaworska J,Sypecka J,Polowy R,Filipkowski RK,Zalewska T

更新日期：2017-09-01 00:00:00

abstract：:During development, neurons migrate to the cortex radially from periventricular germinative zones as well as tangentially from ganglionic eminences. The vast majority of cortical neurons settle radially in the cortical plate. Neuronal migration requires an exquisite regulation of leading edge extension, nuclear transl...

journal_title：Molecular neurobiology

authors： Jossin Y

更新日期：2004-12-01 00:00:00

abstract：:Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...

journal_title：Molecular neurobiology

authors： Matthys A,Haegeman G,Van Craenenbroeck K,Vanhoenacker P

更新日期：2011-06-01 00:00:00

abstract：:Recent evidence suggests that hypoxia preconditioning can alter the microRNA (miRNA) profile of extracellular vesicles (EVs) and has better neuroprotective effects when enriched miRs are delivered to recipients. However, the roles of exosomal miRNAs in regulating ischaemia-reperfusion (IR)-induced pain hypersensitivit...

journal_title：Molecular neurobiology

authors： Wang H,Chen FS,Zhang ZL,Zhou HX,Ma H,Li XQ

更新日期：2021-02-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The Fig. 7 sub-panel "f" was missing in the figure of the online first proofs of this article. The corrected Fig. 7 is hereby given below. ...

journal_title：Molecular neurobiology

authors： Zieger E,Candiani S,Garbarino G,Croce JC,Schubert M

更新日期：2018-06-01 00:00:00

abstract：:Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...

journal_title：Molecular neurobiology

authors： Wang J,Yu JT,Tan L

更新日期：2015-04-01 00:00:00

abstract：:Evidence indicates that adverse experiences in early life may be a factor for immune disturbances leading to the depression in adulthood. Recently, a pivotal role in the pathogenesis of depression has been assigned to the activation of the brain Nod-like receptor pyrin-containing 3 (NLRP3) inflammasome. We investigate...

journal_title：Molecular neurobiology

authors： Trojan E,Chamera K,Bryniarska N,Kotarska K,Leśkiewicz M,Regulska M,Basta-Kaim A

更新日期：2019-08-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) is an inborn error of metabolism caused by a severe deficiency in the activity of the branched-chain α-keto acid dehydrogenase complex, leading to accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine. Infections have a significant role in precipitating ...

journal_title：Molecular neurobiology

authors： Scaini G,Morais MO,Galant LS,Vuolo F,Dall'Igna DM,Pasquali MA,Ramos VM,Gelain DP,Moreira JC,Schuck PF,Ferreira GC,Soriano FG,Dal-Pizzol F,Streck EL

更新日期：2014-10-01 00:00:00

abstract：:Dendritic spines, a special kind of structure in nerve cells, play a key role in performing cellular function. Structural abnormalities of the dendritic spine may contribute to synaptic dysfunction and have been implicated in memory formation. However, the molecular mechanisms that trigger dendritic spine loss remain ...

journal_title：Molecular neurobiology

authors： Liu Q,Feng R,Chen Y,Luo G,Yan H,Chen L,Lin R,Ding Y,Wen T

更新日期：2018-01-01 00:00:00

abstract：:Major depression is a serious side effect of interferon-α (IFN-α), which is used in the therapy of hepatitis C virus (HCV) infection. Due to the lack of reproducible animal models, the mechanisms underlying IFN-α-related depression are largely unknown. We herein established a mouse model, in which murine IFN-α (250 IU...

journal_title：Molecular neurobiology

authors： Hoyo-Becerra C,Liu Z,Yao J,Kaltwasser B,Gerken G,Hermann DM,Schlaak JF

更新日期：2015-08-01 00:00:00

abstract：:Alpha synuclein (α-synuclein) is a neuronal protein found predominately in presynaptic terminals. While the pathological effect of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention has been placed on changes in monomeric α-synuclein and related physiologic...

journal_title：Molecular neurobiology

authors： Carlson SW,Yan HQ,Li Y,Henchir J,Ma X,Young MS,Ikonomovic MD,Dixon CE

更新日期：2021-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As the basis of learning and memory, the plasticity of synapse and dendritic spine has been impaired during...

journal_title：Molecular neurobiology

authors： Huang L,Lan J,Tang J,Kang Y,Feng X,Wu L,Peng Y

更新日期：2020-11-03 00:00:00

abstract：:The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...

journal_title：Molecular neurobiology

authors： Cigliano L,Spagnuolo MS,Crescenzo R,Cancelliere R,Iannotta L,Mazzoli A,Liverini G,Iossa S

更新日期：2018-04-01 00:00:00

abstract：:In the field of the neurobiology of learning, significant emphasis has been placed on understanding neural plasticity within a single structure (or synapse type) as it relates to a particular type of learning mediated by a particular brain area. To appreciate fully the breadth of the plasticity responsible for complex...

journal_title：Molecular neurobiology

authors： Mizumori SJ,Cooper BG,Leutgeb S,Pratt WE

更新日期：2000-02-01 00:00:00

abstract：:Establishment of appropriate neuronal connections during development and regeneration requires the extension of processes that must then grow in the correct direction, find and recognize their targets, and make synapses with them. During development, embryonic neurons gradually establish central and peripheral connect...

journal_title：Molecular neurobiology

authors： Kuffler DP

更新日期：1994-08-01 00:00:00

abstract：:Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule...

journal_title：Molecular neurobiology

authors： Mata A,Urrea L,Vilches S,Llorens F,Thüne K,Espinosa JC,Andréoletti O,Sevillano AM,Torres JM,Requena JR,Zerr I,Ferrer I,Gavín R,Del Río JA

更新日期：2017-10-01 00:00:00