A neural systems analysis of adaptive navigation.

abstract：:People suffering from Huntington's disease (HD) present cognitive deficits. Hippocampal dysfunction has been involved in the HD learning and memory impairment, but proteins leading this dysregulation are not fully characterized. Here, we studied the contribution of the family of transcription factors myocyte enhancer ...

journal_title：Molecular neurobiology

authors： Vidal-Sancho L,Fernández-García S,Solés-Tarrés I,Alberch J,Xifró X

更新日期：2020-11-01 00:00:00

abstract：:Neonatal hypoxic-ischemic (HI) injury still remains an important issue as it is a major cause of neonatal death and neurological dysfunctions. Currently, there are no well-established treatments to reduce brain damage and its long-term sequel in infants. Recently, reported data show that histone deacetylase inhibitors...

journal_title：Molecular neurobiology

authors： Ziemka-Nalecz M,Jaworska J,Sypecka J,Polowy R,Filipkowski RK,Zalewska T

更新日期：2017-09-01 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that ...

journal_title：Molecular neurobiology

authors： Xie XQ,Zhang P,Tian B,Chen XQ

更新日期：2017-11-01 00:00:00

abstract：:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...

journal_title：Molecular neurobiology

authors： Gutiérrez IL,González-Prieto M,García-Bueno B,Caso JR,Feinstein DL,Madrigal JLM

更新日期：2018-10-01 00:00:00

abstract：:The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible...

journal_title：Molecular neurobiology

authors： Shen Y,Liu XL,Yang XL

更新日期：2006-12-01 00:00:00

abstract：:Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anx...

journal_title：Molecular neurobiology

authors： Feng B,Liu JC,Zhang J,Ozaki K,Guo YY,Yi DH,Li XQ,Zhao MG

更新日期：2013-06-01 00:00:00

abstract：:Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have shown promise as a rapid-acting antidepressant drugs although with adve...

journal_title：Molecular neurobiology

authors： Gordillo-Salas M,Pascual-Antón R,Ren J,Greer J,Adell A

更新日期：2020-08-01 00:00:00

abstract：:In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...

journal_title：Molecular neurobiology

authors： Castruccio Castracani C,Longhitano L,Distefano A,Di Rosa M,Pittalà V,Lupo G,Caruso M,Corona D,Tibullo D,Li Volti G

更新日期：2020-05-01 00:00:00

abstract：:The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...

journal_title：Molecular neurobiology

authors： Avolio E,Fazzari G,Mele M,Alò R,Zizza M,Jiao W,Di Vito A,Barni T,Mandalà M,Canonaco M

更新日期：2017-10-01 00:00:00

abstract：:Social isolation during the vulnerable period of adolescence produces emotional dysregulation that often manifests as abnormal behavior in adulthood. The enduring consequence of isolation might be caused by a weakened ability to forget unpleasant memories. However, it remains unclear whether isolation affects unpleasa...

journal_title：Molecular neurobiology

authors： Liu JH,You QL,Wei MD,Wang Q,Luo ZY,Lin S,Huang L,Li SJ,Li XW,Gao TM

更新日期：2015-12-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...

journal_title：Molecular neurobiology

authors： Liu S,Zhao Z,Guo Y,Shu H,Li C,Tang Y,Xing Y,Tao F

更新日期：2018-05-01 00:00:00

abstract：:Respiration is a rhythmic motor behavior that appears in the fetus and acquires a vital importance at birth. It is generated within central pattern-generating neuronal networks of the hindbrain. This region of the brain is of particular interest since it is the most understood part with respect to the cellular and mol...

journal_title：Molecular neurobiology

authors： Chatonnet F,Domínguez del Toro E,Thoby-Brisson M,Champagnat J,Fortin G,Rijli FM,Thaëron-Antôno C

更新日期：2003-12-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about ...

journal_title：Molecular neurobiology

authors： Li J,Li H,Liu J,Feng B,Feng M,Lv B,Cheng S,Yang X

更新日期：2016-07-01 00:00:00

abstract：:Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy or early childhood. While several hypotheses have been proposed to explain the occurrence of IA, the neurobiological and molecular bases for this accelerated forgetting phenomenon remain elusive. Using hippocampus-depende...

journal_title：Molecular neurobiology

authors： Tsai TC,Huang CC,Hsu KS

更新日期：2019-02-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that are normally transduced by endogenous ligands. Moreover, antibody binding ...

journal_title：Molecular neurobiology

authors： Dyer CA

更新日期：1993-04-01 00:00:00

abstract：:Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...

journal_title：Molecular neurobiology

authors： Boutin H,Kimber I,Rothwell NJ,Pinteaux E

更新日期：2003-06-01 00:00:00

abstract：:The aim of this work was to study the effect of glucagon-like peptide-2 (GLP-2) on the cyclic guanosine monophosphate (cGMP) signalling pathway and whether insulin or epidermal growth factor (EGF) might modulate the effects of GLP-2. GLP-2 produced a dose-dependent decrease in intracellular sodium nitroprusside-induce...

journal_title：Molecular neurobiology

authors： Velázquez E,Blázquez E,Ruiz-Albusac JM

更新日期：2012-10-01 00:00:00

abstract：:Morphine as an opioid is an important drug in the treatment of moderate to severe pain. Several stress factors via generation of nitric oxide (NO) and oxidative stress (OS) are responsible for the adverse effects of morphine-induced analgesia, addiction, and antinociceptive tolerance, including altered Ca2+ concentrat...

journal_title：Molecular neurobiology

authors： Osmanlıoğlu HÖ,Yıldırım MK,Akyuva Y,Yıldızhan K,Nazıroğlu M

更新日期：2020-08-01 00:00:00

abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

journal_title：Molecular neurobiology

authors： Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

更新日期：2020-11-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to play a critical role in the development of several malignancies. However, the potential molecular mechanism of MALAT1 in glioma remains unclear. In the present study, we found that the expression of MALAT1 wa...

journal_title：Molecular neurobiology

authors： Cheng H,Zhao H,Xiao X,Huang Q,Zeng W,Tian B,Ma T,Lu D,Jin Y,Li Y

更新日期：2020-10-19 00:00:00

abstract：:Atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their...

journal_title：Molecular neurobiology

authors： Cai T,Groves AK

更新日期：2015-12-01 00:00:00

abstract：:Accumulating evidence indicates a critical implication of DNA methylation in the brain development. We aim to determine whether the disruption of DNA methylation patterns in the developing brain adversely affects neurobehavioral phenotypes later in life in a sex-dependent manner. 5-Aza-2'-deoxycytidine (5-Aza), a DNA ...

journal_title：Molecular neurobiology

authors： Li Y,Ma Q,Dasgupta C,Halavi S,Hartman RE,Xiao D,Zhang L

更新日期：2017-08-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...

journal_title：Molecular neurobiology

authors： Nakka VP,Prakash-Babu P,Vemuganti R

更新日期：2016-01-01 00:00:00

abstract：:Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel's S4-S5 linker,...

journal_title：Molecular neurobiology

authors： Bu W,Liang Q,Zhi L,Maciunas L,Loll PJ,Eckenhoff RG,Covarrubias M

更新日期：2018-02-01 00:00:00

abstract：:Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. The similarities in pathogenesis have been confirmed by findings that ...

journal_title：Molecular neurobiology

authors： Figiel M,Szlachcic WJ,Switonski PM,Gabka A,Krzyzosiak WJ

更新日期：2012-10-01 00:00:00

abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...

journal_title：Molecular neurobiology

authors： Hochgräfe K,Mandelkow EM

更新日期：2013-06-01 00:00:00

abstract：:The chronic stage multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), remains refractory to current treatments. This refractory nature may be due to the fact that current treatments are primarily immunomodulatory, which prevent further demyelination but lack the capacity...

journal_title：Molecular neurobiology

authors： Li X,Zhang Y,Yan Y,Ciric B,Ma CG,Chin J,Curtis M,Rostami A,Zhang GX

更新日期：2017-08-01 00:00:00

abstract：:Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis (ALS), while wild-type TDP-43 is a pathological hallmark of patients with sporadic ALS and frontotemporal lobar degeneration (FTLD). Various in vitro and in vivo studies have also demonstrated toxicity ...

journal_title：Molecular neurobiology

authors： Janssens J,Wils H,Kleinberger G,Joris G,Cuijt I,Ceuterick-de Groote C,Van Broeckhoven C,Kumar-Singh S

更新日期：2013-08-01 00:00:00