Abstract:
:Respiration is a rhythmic motor behavior that appears in the fetus and acquires a vital importance at birth. It is generated within central pattern-generating neuronal networks of the hindbrain. This region of the brain is of particular interest since it is the most understood part with respect to the cellular and molecular mechanisms that underlie its development. Hox paralogs and Hox-regulating genes kreisler/mafB and Krox20 are required for the normal formation of rhombomeres in vertebrate embryos. From studies of rhombomeres r3 and r4, the authors review mechanisms whereby these developmental genes may govern the early embryonic development of para-facial neuronal networks and specify patterns of motor activities operating throughout life. A model whereby the regional identity of progenitor cells can be abnormally specified in r3 and r4 after a mutation of these genes is proposed. Novel neuronal circuits may develop from some of these misspecified progenitors while others are eliminated, eventually affecting respiration and survival after birth.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Chatonnet F,Domínguez del Toro E,Thoby-Brisson M,Champagnat J,Fortin G,Rijli FM,Thaëron-Antôno Cdoi
10.1385/mn:28:3:277subject
Has Abstractpub_date
2003-12-01 00:00:00pages
277-94issue
3eissn
0893-7648issn
1559-1182pii
MN:28:3:277journal_volume
28pub_type
杂志文章,评审abstract::Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9796-3
更新日期:2017-04-01 00:00:00
abstract::Hypertension is one of the co-morbid conditions for stroke and profoundly increases its incidence. Angiotensin II (AngII) is shown to be at the center stage in driving the renin angiotensin system via activation of angiotensin 1 receptor (AT1R). This makes the AT1R gene one of the candidates whose differential regulat...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9109-2
更新日期:2016-04-01 00:00:00
abstract::Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of multiple sclerosis (MS) for the development of new therapies. Dopamine receptors can modulate EAE and MS development, thus highlighting the potential use of dopaminergic agonists in the treatment of MS, which has been poorly explored. Her...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9717-5
更新日期:2017-03-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-016-0013-1
更新日期:2016-11-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0349-6
更新日期:2018-01-01 00:00:00
abstract::During development, neurons migrate to the cortex radially from periventricular germinative zones as well as tangentially from ganglionic eminences. The vast majority of cortical neurons settle radially in the cortical plate. Neuronal migration requires an exquisite regulation of leading edge extension, nuclear transl...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1385/MN:30:3:225
更新日期:2004-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01782-8
更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s12035-018-1031-y
更新日期:2018-12-01 00:00:00
abstract::Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. The similarities in pathogenesis have been confirmed by findings that ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8315-4
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abstract::Heat shock proteins (Hsps) are highly conserved proteins that are induced in response to various physiological and environmental stressors. HspB1 (Hsp27) is a prominent member of the small Hsps family and is strongly induced during the stress response. Notably, HspB1 has powerful neuroprotective effects, increasing th...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
abstract::Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9610-7
更新日期:2016-12-01 00:00:00
abstract::Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel's S4-S5 linker,...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0437-2
更新日期:2018-02-01 00:00:00
abstract::A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...
journal_title:Molecular neurobiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12035-015-9261-8
更新日期:2016-05-01 00:00:00
abstract::Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1444-7
更新日期:2019-07-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/BF02935552
更新日期:1991-01-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8924-1
更新日期:2015-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-8683-z
更新日期:2014-10-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-012-8383-5
更新日期:2013-06-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8740-7
更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2021-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章,meta分析,收录出版
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-020-02084-0
更新日期:2020-12-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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abstract::This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00
abstract::A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01819-y
更新日期:2020-03-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Molecular neurobiology
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00