Spinal AMPA Receptor GluA1 Ser831 Phosphorylation Controls Chronic Alcohol Consumption-Produced Prolongation of Postsurgical Pain.

abstract：:Metabolic stress induced by high-fat (HF) diet leads to cognitive dysfunction and aging, but the physiological mechanisms are not fully understood. Senescence-accelerated prone mouse (SAMP8) models were conducted under metabolic stress conditions by feeding HF for 15 weeks, and the preventive effect of resveratrol was...

journal_title：Molecular neurobiology

authors： Palomera-Avalos V,Griñán-Ferré C,Puigoriol-Ilamola D,Camins A,Sanfeliu C,Canudas AM,Pallàs M

更新日期：2017-04-01 00:00:00

abstract：:Voltage-gated calcium channels (VGCCs) play a critical role in neuroinflammatory diseases, such as multiple sclerosis (MS). CTK 01512-2 is a recombinant version of the peptide Phα1β derived from the spider Phoneutria nigriventer, which inhibits N-type VGCC/TRPA1-mediated calcium influx. We investigated the effects of ...

journal_title：Molecular neurobiology

authors： Silva RBM,Greggio S,Venturin GT,da Costa JC,Gomez MV,Campos MM

更新日期：2018-12-01 00:00:00

abstract：:Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism spectrum disorders. The PSD is a thickness, detectable at electronic microscopy, localized at the postsynaptic membrane of glutamatergic syna...

journal_title：Molecular neurobiology

authors： de Bartolomeis A,Latte G,Tomasetti C,Iasevoli F

更新日期：2014-02-01 00:00:00

abstract：:CRMP1, a member of the collapsin response mediator protein family (CRMPs), was reported to regulate axon outgrowth in Sema3A signaling pathways via interactions with its co-receptor protein neuropilin-1 and plexin-As through the Fyn-cyclin-dependent kinase 5 (CDK5) cascade and the sequential phosphorylation of CRMP1 b...

journal_title：Molecular neurobiology

authors： Yao L,Liu YH,Li X,Ji YH,Yang XJ,Hang XT,Ding ZM,Liu F,Wang YH,Shen AG

更新日期：2016-03-01 00:00:00

abstract：:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...

journal_title：Molecular neurobiology

authors： Gutiérrez IL,González-Prieto M,García-Bueno B,Caso JR,Feinstein DL,Madrigal JLM

更新日期：2018-10-01 00:00:00

abstract：:This study examined the association between elevated plasma homocysteine (Hcy) levels and the risk of acute cerebral infarction in patients with carotid artery lesions. A total of 78 patients were divided into two groups, the high Hcy group (n = 38; Hcy levels >15 umol/L) and the low Hcy group (n = 40; Hcy levels ≤15 ...

journal_title：Molecular neurobiology

authors： Wu W,Guan Y,Xu K,Fu XJ,Lei XF,Lei LJ,Zhang ZQ,Cheng Y,Li YQ

更新日期：2016-05-01 00:00:00

abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...

journal_title：Molecular neurobiology

authors： Oliveira SR,Figueiredo-Pereira C,Duarte CB,Vieira HLA

更新日期：2019-05-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...

journal_title：Molecular neurobiology

authors： Boghdadi AG,Teo L,Bourne JA

更新日期：2018-03-01 00:00:00

abstract：:The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathoge...

journal_title：Molecular neurobiology

authors： Chelluboina B,Nalamolu KR,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

更新日期：2018-02-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) ...

journal_title：Molecular neurobiology

authors： Davis SM,Collier LA,Leonardo CC,Seifert HA,Ajmo CT Jr,Pennypacker KR

更新日期：2017-01-01 00:00:00

abstract：:Familial (FAD) and sporadic (SAD) Alzheimer's disease do not share all pathomechanisms, but knowledge on their molecular differences is limited. We previously reported that cell cycle control distinguishes lymphocytes from SAD and FAD patients. Significant differences were found in p21 levels of SAD compared to FAD ly...

journal_title：Molecular neurobiology

authors： Wojsiat J,Laskowska-Kaszub K,Alquézar C,Białopiotrowicz E,Esteras N,Zdioruk M,Martin-Requero A,Wojda U

更新日期：2017-09-01 00:00:00

abstract：:For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...

journal_title：Molecular neurobiology

authors： Leuner B,Shors TJ

更新日期：2004-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease that leads to neuronal cell loss. Cyclic AMP and its analogs are well known to decrease inflammation and apoptosis. In the present study, we examined the effects of bucladesine, a cell-permeable analogue of cyclic adenosine monophosphate (cAMP), on myeli...

journal_title：Molecular neurobiology

authors： Vakilzadeh G,Khodagholi F,Ghadiri T,Darvishi M,Ghaemi A,Noorbakhsh F,Gorji A,Sharifzadeh M

更新日期：2015-08-01 00:00:00

abstract：:Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elev...

journal_title：Molecular neurobiology

authors： Nelson TJ,Alkon DL

更新日期：1991-01-01 00:00:00

abstract：:The discovery of α-synuclein has had profound implications concerning our understanding of Parkinson's disease (PD) and other neurodegenerative disorders characterized by α-synuclein accumulation. In fact, as compared with pre-α-synuclein times, a "new" PD can now be described as a whole-body disease in which a progre...

journal_title：Molecular neurobiology

authors： Ulusoy A,Di Monte DA

更新日期：2013-04-01 00:00:00

abstract：:Regulatory mechanisms of the expression of interleukin-10 (IL-10) in brain inflammatory conditions remain elusive. To address this issue, we used multiple primary brain cell cultures to study the expression of IL-10 in lipopolysaccharide (LPS)-elicited inflammatory conditions. In neuron-glia cultures, LPS triggered we...

journal_title：Molecular neurobiology

authors： Chu CH,Chen SH,Wang Q,Langenbach R,Li H,Zeldin D,Chen SL,Wang S,Gao H,Lu RB,Hong JS

更新日期：2015-08-01 00:00:00

abstract：:Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals i...

journal_title：Molecular neurobiology

authors： Zhou Y,Yang T,Gong Y,Li W,Chen Y,Li J,Wang M,Yin X,Hu B,Lu Z

更新日期：2017-05-01 00:00:00

abstract：:Arduous efforts have been made in the last three decades to elucidate the role of insulin in the brain. A growing number of evidences show that insulin is involved in several physiological function of the brain such as food intake and weight control, reproduction, learning and memory, neuromodulation and neuroprotecti...

journal_title：Molecular neurobiology

authors： Ghasemi R,Dargahi L,Haeri A,Moosavi M,Mohamed Z,Ahmadiani A

更新日期：2013-06-01 00:00:00

abstract：:Fear is crucial for survival, whereas hypermnesia of fear can be detrimental. Inhibition of the Rac GTPase is recently reported to impair the forgetting of initially acquired memory in Drosophila. Here, we investigated whether inhibition of Rac1 activity in rat hippocampus could contribute to the hypermnesia of contex...

journal_title：Molecular neurobiology

authors： Jiang L,Mao R,Zhou Q,Yang Y,Cao J,Ding Y,Yang Y,Zhang X,Li L,Xu L

更新日期：2016-03-01 00:00:00

abstract：:Maternal hypothyroxinemia can induce neurodevelopmental impairments in the developing fetus. We here review recent studies on the epidemiology and molecular mechanisms associated with this important public health issue. In 2011, the American Thyroid Association defined maternal hypothyroxinemia as low serum free thyro...

journal_title：Molecular neurobiology

authors： Min H,Dong J,Wang Y,Wang Y,Teng W,Xi Q,Chen J

更新日期：2016-04-01 00:00:00

abstract：:The neuronal circuit remodels during development as well as in human neuropathologies such as epilepsy. Neurite outgrowth is an obligatory step in these events. We recently reported that alterations in the phosphorylation state of an axon specification/guidance protein, the collapsin response mediator protein 2 (CRMP2...

journal_title：Molecular neurobiology

authors： Moutal A,François-Moutal L,Perez-Miller S,Cottier K,Chew LA,Yeon SK,Dai J,Park KD,Khanna M,Khanna R

更新日期：2016-04-01 00:00:00

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational regulation, stress granule formation, cell cycle regulation, and axonal t...

journal_title：Molecular neurobiology

authors： Low YH,Asi Y,Foti SC,Lashley T

更新日期：2021-02-01 00:00:00

abstract：:Males are predominantly affected by autism spectrum disorders (ASD) with a prevalence ratio of 5:1. However, the underlying pathological mechanisms governing the male preponderance of ASD remain unclear. Recent studies suggested that epigenetic aberrations may cause synaptic dysfunctions, which might be related to the...

journal_title：Molecular neurobiology

authors： Kim KC,Choi CS,Kim JW,Han SH,Cheong JH,Ryu JH,Shin CY

更新日期：2016-01-01 00:00:00

abstract：:Accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in several neurodegenerative disorders. Therefore, development of methods for microglial inhibition is considered an important strategy in the search for neuroprotect...

journal_title：Molecular neurobiology

authors： Lu DY,Huang BR,Yeh WL,Lin HY,Huang SS,Liu YS,Kuo YH

更新日期：2013-12-01 00:00:00

abstract：:Dodecafluoropentane emulsion (DDFPe) in 250 nm nanodroplets seems to swell modestly to accept and carry large amounts of oxygen in the body at >29 °C. Small particle size allows oxygen delivery even into hypoxic tissue unreachable by erythrocytes. Using permanent cerebral embolic occlusion in rabbits, we assessed DDFP...

journal_title：Molecular neurobiology

authors： Woods SD,Skinner RD,Ricca AM,Brown AT,Lowery JD,Borrelli MJ,Lay JO,Culp WC

更新日期：2013-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by intelligence decline, behavioral disorders and cognitive disability. The purpose of this study was to investigate gene expression in AD, based on published microarray data on Tg2576 mice. Hierarchical Cluster Analysis and Gene Ontol...

journal_title：Molecular neurobiology

authors： Tan L,Wang X,Ni ZF,Zhu X,Wu W,Zhu LQ,Liu D

更新日期：2013-06-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a modern socioeconomic burden, mostly due to its long-term complications affecting nearly all tissues. One of them is the brain, whose dysfunctional intracellular quality control mechanisms (namely autophagy) may upregulate apoptosis, leading to cognitive dysfunction and Alzheimer disease (AD)...

journal_title：Molecular neurobiology

authors： Candeias E,Sebastião I,Cardoso S,Carvalho C,Santos MS,Oliveira CR,Moreira PI,Duarte AI

更新日期：2018-05-01 00:00:00

abstract：:Although in-hospital mortality rates for sepsis have decreased, survivors often experience lasting physical and cognitive deficits. Moreover, older adults are more vulnerable to long-term complications associated with sepsis. We employed a murine model to examine the influence of age and sex on the brain's response an...

journal_title：Molecular neurobiology

authors： Barter J,Kumar A,Stortz JA,Hollen M,Nacionales D,Efron PA,Moldawer LL,Foster TC

更新日期：2019-12-01 00:00:00