Abstract：
:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies have attempted to elucidate the biochemical and molecular mechanisms that inhibit neuronal repair with increasing evidence suggesting that several inhibitory factors and repulsive guidance cues active during development actually persist into adulthood and may be contributing to the inhibition of repair. For example, in the injured adult CNS, there are various inhibitory factors that impede the outgrowth of neurites from damaged neurons. One of the most potent of these neurite outgrowth inhibitors is the group of proteins known as the myelin-associated inhibitors (MAIs), present mainly on the membranes of oligodendroglia. Several studies have shown that interfering with these proteins can have positive outcomes in CNS injury models by promoting neurite outgrowth and improving functional recovery. As such, the MAIs, their receptors, and downstream effectors are valid drug targets for the treatment of CNS injury. This review will discuss the current literature on MAIs in the context of CNS development, plasticity, and injury. Molecules that interfere with the MAIs and their receptors as potential candidates for the treatment of CNS injury will additionally be introduced in the context of preclinical and clinical trials.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Boghdadi AG,Teo L,Bourne JAdoi
10.1007/s12035-017-0433-6subject
Has Abstractpub_date
2018-03-01 00:00:00pages
1831-1846issue
3eissn
0893-7648issn
1559-1182pii
10.1007/s12035-017-0433-6journal_volume
55pub_type
杂志文章,评审abstract：:Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects o...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02164-1
更新日期：2020-10-15 00:00:00
abstract：:Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy or early childhood. While several hypotheses have been proposed to explain the occurrence of IA, the neurobiological and molecular bases for this accelerated forgetting phenomenon remain elusive. Using hippocampus-depende...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1119-4
更新日期：2019-02-01 00:00:00
abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-019-1504-7
更新日期：2019-09-01 00:00:00
abstract：:The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal models of ischaemic str...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0697-x
更新日期：2018-06-01 00:00:00
abstract：:Thyroid hormone plays an important role in central nervous system (CNS) development, including the myelination of variable axonal calibers. It is well-established that thyroid hormone is required for the terminal differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes by inducing ra...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-016-0013-1
更新日期：2016-11-01 00:00:00
abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9249-4
更新日期：2015-10-01 00:00:00
abstract：:Neuroinflammation is the important pathological feature of Alzheimer's disease (AD). Legumain, a lysosomal cysteine protease, plays an important role in neuroinflammation during ischemic stroke and depressive disorder. Legumain is involved in AD process through cleaving APP; however, it is unclear if legumain can poss...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02219-3
更新日期：2020-11-21 00:00:00
abstract：:The study of sporadic Alzheimer's disease etiology, now more than ever, needs an infusion of new concepts. Despite ongoing interest in Alzheimer's disease, the basis of this entity is not yet clear. At present, the best-established and accepted "culprit" in Alzheimer's disease pathology by most scientists is the amylo...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8439-1
更新日期：2013-12-01 00:00:00
abstract：:Synaptic vesicle proton V-ATPase is an essential component in synaptic vesicle function. Active acidification of synaptic vesicles, triggered by the V-ATPase, is necessary for neurotransmitter storage. Independently from its proton transport activity, an additional important function of the membrane-embedded sector of...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1324-1
更新日期：2019-05-01 00:00:00
abstract：:Human hGDH2 arose via duplication in the apes and driven by positive selection acquired enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all mammals). To explore the biological advantage provided by the novel enzyme, we studied, by immunohistochemistry (IHC) and immunofluorescen...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9429-2
更新日期：2016-10-01 00:00:00
abstract：:The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9638-8
更新日期：2017-01-01 00:00:00
abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9748-y
更新日期：2017-03-01 00:00:00
abstract：:Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH,...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9242-y
更新日期：2016-07-01 00:00:00
abstract：:Establishment of appropriate neuronal connections during development and regeneration requires the extension of processes that must then grow in the correct direction, find and recognize their targets, and make synapses with them. During development, embryonic neurons gradually establish central and peripheral connect...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02816122
更新日期：1994-08-01 00:00:00
abstract：:Conventional antidepressant drugs elevate the availability of monoamine neurotransmitters. However, these pharmacological therapies have limited efficacy and a slow onset of action as main limitations. New glutamatergic drugs such as ketamine have shown promise as a rapid-acting antidepressant drugs although with adve...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-01954-x
更新日期：2020-08-01 00:00:00
abstract：:The connection between the endocannabinoid system (ECS) and schizophrenia is supported by a large body of research. The ECS is composed of two types cannabinoid (CB: CB1 and CB2) receptors and their endogenous ligands, endocannabinoids. The best-known endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1596-0
更新日期：2019-11-01 00:00:00
abstract：:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0960-9
更新日期：2018-10-01 00:00:00
abstract：:Prenatal ethanol exposure can cause extensive apoptotic neurodegeneration throughout the developing central nervous system (CNS), which results in cognitive deficits and memory decline. However, the underlying mechanisms need further study. Single-minded 2 (Sim2), a transcriptional repressor, is reportedly involved in...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8924-1
更新日期：2015-12-01 00:00:00
abstract：:The considerable roles of transcription factors, and the associated signaling molecules that activate them, are well deciphered in the context of various biological processes. One of the important transcription factors, the transforming growth factor-β (TGF-β) pathway, has a profound role in neuronal cell survival-a p...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8988-y
更新日期：2016-01-01 00:00:00
abstract：:Neurons with a desired neurotransmitter phenotype can be differentiated from induced pluripotent stem cells or from somatic cells only through tedious protocols with relatively low yield. Readily available cortical neurons isolated from embryonic rat brain, which have already undergone a complete neuronal differentiat...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01701-x
更新日期：2020-01-01 00:00:00
abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0144-4
更新日期：2017-10-01 00:00:00
abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8379-1
更新日期：2013-06-01 00:00:00
abstract：:Metals perform important functions in the normal physiological system, and alterations in their levels may lead to a number of diseases. Aluminium (Al) has been implicated as a major risk factor, which is linked to several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. On the other h...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8643-7
更新日期：2014-10-01 00:00:00
abstract：:Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide association and other genetic studies have implicated at least 500+ genes associated with the occurrence of autism spectrum disorders (ASD) including the human semaphorin 3F (Sema 3F) and neuropilin 2 (NRP2) genes. However, the geneti...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1450-9
更新日期：2019-08-01 00:00:00
abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9935-x
更新日期：2017-07-01 00:00:00
abstract：:TREK-1, a two-pore-domain K+ channel, is highly expressed in the central nervous system. Although aberrant expression of TREK-1 is implicated in cognitive impairment, the cellular and functional mechanism underlying this channelopathy is poorly understood. Here we examined TREK-1 contribution to neuronal morphology, e...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01828-x
更新日期：2020-03-01 00:00:00
abstract：:Depletion of oxygen and glucose even for brief periods is sufficient to cause cerebral ischemia, which is a predominant worldwide cause of motor deficits with the reduction of life quality and subsequently death. Hence, more insights regarding protective measures against ischemic events are becoming a major research g...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0240-5
更新日期：2017-11-01 00:00:00
abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...
journal_title：Molecular neurobiology
pub_type： 已发布勘误
doi：10.1007/s12035-018-1095-8
更新日期：2018-10-01 00:00:00
abstract：:In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0900-8
更新日期：2018-10-01 00:00:00
abstract：:Iron accumulates progressively in the brain with age, and iron-induced oxidative stress has been considered as one of the initial causes for Alzheimer's disease (AD) and Parkinson's disease (PD). Based on the role of hepcidin in peripheral organs and its expression in the brain, we hypothesized that this peptide has a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8847-x
更新日期：2015-08-01 00:00:00
