Abstract:
:Synaptic vesicle proton V-ATPase is an essential component in synaptic vesicle function. Active acidification of synaptic vesicles, triggered by the V-ATPase, is necessary for neurotransmitter storage. Independently from its proton transport activity, an additional important function of the membrane-embedded sector of the V-ATPase has been uncovered over recent years. Subunits a and c of the membrane sector of this multi-molecular complex have been shown to interact with SNARE proteins and to be involved in modulating neurotransmitter release. The c-subunit interacts with the v-SNARE VAMP2 and facilitates neurotransmission. In this study, we used chromophore-assisted light inactivation and monitored the consequences on neurotransmission on line in CA3 pyramidal neurons. We show that V-ATPase c-subunit V0c is a key element in modulating neurotransmission and that its specific inactivation rapidly inhibited neurotransmission.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Rama S,Boumedine-Guignon N,Sangiardi M,Youssouf F,Maulet Y,Lévêque C,Belghazi M,Seagar M,Debanne D,El Far Odoi
10.1007/s12035-018-1324-1subject
Has Abstractpub_date
2019-05-01 00:00:00pages
3591-3602issue
5eissn
0893-7648issn
1559-1182pii
10.1007/s12035-018-1324-1journal_volume
56pub_type
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