Effect of CR1 Genetic Variants on Cerebrospinal Fluid and Neuroimaging Biomarkers in Healthy, Mild Cognitive Impairment and Alzheimer's Disease Cohorts.

abstract：:A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis of infections, and interrogation of vaccine response. We hypothesized that there is an immunosignature specific...

journal_title：Molecular neurobiology

authors： Günther OP,Gardy JL,Stafford P,Fluge Ø,Mella O,Tang P,Miller RR,Parker SM,Johnston SA,Patrick DM

更新日期：2019-06-01 00:00:00

abstract：:The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD) remain largely unclear. In the present study, we were aimed to identify the potential key molecules involved in spatial memory impairment in a triple transgenic (3xTg-AD) mouse model of AD. By employing two-dimensional fluorescence di...

journal_title：Molecular neurobiology

authors： Ying M,Sui X,Zhang Y,Sun Q,Qu Z,Luo X,Chang RC,Ni J,Liu J,Yang X

更新日期：2017-07-01 00:00:00

abstract：:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...

journal_title：Molecular neurobiology

authors： Suvarna Y,Maity N,Shivamurthy MC

更新日期：2016-05-01 00:00:00

abstract：:We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized...

journal_title：Molecular neurobiology

authors： Steg G,Johnels B

更新日期：1994-08-01 00:00:00

abstract：:Extracellular nucleotides, particularly adenosine 5'-triphosphate (ATP), act as signaling molecules in the inner ear. Roles as neurotransmitters, neuromodulators, and as autocrine or paracrine humoral factors are evident. The diversity of the signaling pathways for nucleotides, which include a variety of ATP-gated ion...

journal_title：Molecular neurobiology

authors： Housley GD

更新日期：1998-02-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...

journal_title：Molecular neurobiology

authors： Schlief ML,Gitlin JD

更新日期：2006-04-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...

journal_title：Molecular neurobiology

authors： da Encarnação TG,Portugal CC,Nogueira CE,Santiago FN,Socodato R,Paes-de-Carvalho R

更新日期：2018-10-01 00:00:00

abstract：:YKL-40 is the most highly expressed gene in glioblastoma compared with normal brain tissues. Previous studies assessing the association between YKL-40 and survival in glioblastoma patients reported varying magnitude of estimates. The objective of this meta-analysis was to determine the prognostic value of YKL-40 in gl...

journal_title：Molecular neurobiology

authors： Qin G,Li X,Chen Z,Liao G,Su Y,Chen Y,Zhang W

更新日期：2017-07-01 00:00:00

abstract：:Neonatal hypoxic-ischemic (HI) injury still remains an important issue as it is a major cause of neonatal death and neurological dysfunctions. Currently, there are no well-established treatments to reduce brain damage and its long-term sequel in infants. Recently, reported data show that histone deacetylase inhibitors...

journal_title：Molecular neurobiology

authors： Ziemka-Nalecz M,Jaworska J,Sypecka J,Polowy R,Filipkowski RK,Zalewska T

更新日期：2017-09-01 00:00:00

abstract：:Ginsenoside Rg1 is efficient to prevent or treat mental disorders. However, the mechanisms underlying the effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD) are still not known. In this study, single-prolonged stress (SPS) regime, as well as injection of lipopolysaccharide (LPS), was used to produce P...

journal_title：Molecular neurobiology

authors： Zhang Z,Song Z,Shen F,Xie P,Wang J,Zhu AS,Zhu G

更新日期：2020-11-19 00:00:00

abstract：:Oxidative stress is a key component of the pathological cascade in subarachnoid hemorrhage (SAH). Fucoxanthin (Fx) possesses a strong antioxidant property and has shown neuroprotective effects in acute brain injuries such as ischemic stroke and traumatic brain injury. Here, we investigated the beneficial effects of Fx...

journal_title：Molecular neurobiology

authors： Zhang XS,Lu Y,Tao T,Wang H,Liu GJ,Liu XZ,Liu C,Xia DY,Hang CH,Li W

更新日期：2020-12-01 00:00:00

abstract：:Alzheimer's disease (AD) and diabetes are among the most common diseases associated with ageing. The pathology of AD is strongly associated with accumulated misfolding proteins that results in neuronal dysfunction within the brain. Diabetes, on the contrary, is characterised by altered insulin signaling that results i...

journal_title：Molecular neurobiology

authors： Ahmad W

更新日期：2013-02-01 00:00:00

abstract：:Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...

journal_title：Molecular neurobiology

authors： Weise SC,Arumugam G,Villarreal A,Videm P,Heidrich S,Nebel N,Dumit VI,Sananbenesi F,Reimann V,Craske M,Schilling O,Hess WR,Fischer A,Backofen R,Vogel T

更新日期：2019-07-01 00:00:00

abstract：:The use of statins for the prevention or treatment of different neurodegenerative diseases has generated considerable interest albeit with some controversy. Mechanisms of statin-induced neuroprotection are not well understood. Recently, we reported that simvastatin stimulated neuronal gene expression and protein level...

journal_title：Molecular neurobiology

authors： Butterick TA,Igbavboa U,Eckert GP,Sun GY,Weisman GA,Müller WE,Wood WG

更新日期：2010-06-01 00:00:00

abstract：:Military personnel are often subjected to sleep deprivation (SD) during combat operations. Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility exists that acute or long-term SD will influence blood-brain barrier (BBB) function and brain pathology. This hypothesis was examined in...

journal_title：Molecular neurobiology

authors： Sharma A,Muresanu DF,Lafuente JV,Patnaik R,Tian ZR,Buzoianu AD,Sharma HS

更新日期：2015-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...

journal_title：Molecular neurobiology

authors： Jindal V

更新日期：2018-11-01 00:00:00

abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...

journal_title：Molecular neurobiology

authors： Geng X,Li F,Yip J,Peng C,Elmadhoun O,Shen J,Ji X,Ding Y

更新日期：2017-12-01 00:00:00

abstract：:Previous studies have postulated that neuroinflammation can induce two different types of reactive astrocytes, A1 and A2. A1 astrocytes may be harmful, whereas A2 astrocytes may be protective. Specifically, prokineticin 2 (PK2) has been shown to regulate neuron-astrocyte signaling mechanism by promoting an alternative...

journal_title：Molecular neurobiology

authors： Ma M,Li H,Wu J,Zhang Y,Shen H,Li X,Wang Z,Chen G

更新日期：2020-09-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neurogenesis contributes to cognition. It is known that enriched environment (EE) enhances neurogenesis. We determined whether EE attenuated surgery-induced cognitive impairment and whether growth factors and neurogenesis played a role in t...

journal_title：Molecular neurobiology

authors： Fan D,Li J,Zheng B,Hua L,Zuo Z

更新日期：2016-01-01 00:00:00

abstract：:Stroke is the leading cause of severe disability, and lacunar stroke is related to cognitive decline and hemiparesis. There is no effective treatment for the majority of patients with stroke. Thus, stem cell-based regenerative medicine has drawn a growing body of attention due to the capabilities for trophic factor ex...

journal_title：Molecular neurobiology

authors： Jablonska A,Drela K,Wojcik-Stanaszek L,Janowski M,Zalewska T,Lukomska B

更新日期：2016-11-01 00:00:00

abstract：:Previous studies have provided evidence for axon-to-myelin transfer of intact lipids and lipid precursors for reutilization by myelin enzymes. Several of the lipid constituents of myelin showed significant contralateral/ipsilateral ratios of incorporated radioactivity, indicative of axonal origin, whereas proteins and...

journal_title：Molecular neurobiology

authors： Ledeen RW,Golly F,Haley JE

更新日期：1992-07-01 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1/KDM1A) plays an important role in complex cellular processes such as differentiation, proliferation, apoptosis, and cell cycle progression. It has recently been demonstrated that during development, downregulation of LSD1 inhibits cell proliferation, modulates the expression of cell...

journal_title：Molecular neurobiology

authors： He Y,Tang D,Cai C,Chai R,Li H

更新日期：2016-05-01 00:00:00

abstract：:The various cell types in the vertebrate retina arise from a pool of common progenitors. The way that the cell types are specified has been a long-standing issue. Decades of research have yielded a large body of information regarding the involvement of extrinsic factors, and only recently has the function of intrinsic...

journal_title：Molecular neurobiology

authors： Yan RT,Ma W,Liang L,Wang SZ

更新日期：2005-10-01 00:00:00

abstract：:Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable ...

journal_title：Molecular neurobiology

authors： Godoy JA,Valdivieso AG,Inestrosa NC

更新日期：2018-12-01 00:00:00

abstract：:Carbon monoxide (CO) is an endogenous gasotransmitter that limits inflammation and prevents apoptosis in several tissues, including the brain. Low concentrations of CO are cytoprotective in astrocytes, neurons, and microglia, but the underlying molecular mechanisms remain poorly understood. This work aims at identific...

journal_title：Molecular neurobiology

authors： Oliveira SR,Figueiredo-Pereira C,Duarte CB,Vieira HLA

更新日期：2019-05-01 00:00:00

abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

journal_title：Molecular neurobiology

authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

更新日期：2017-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...

journal_title：Molecular neurobiology

authors： Xiang Q,Bi R,Xu M,Zhang DF,Tan L,Zhang C,Fang Y,Yao YG

更新日期：2017-09-01 00:00:00

abstract：:The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgeni...

journal_title：Molecular neurobiology

authors： Moutinho M,Nunes MJ,Gomes AQ,Gama MJ,Cedazo-Minguez A,Rodrigues CM,Björkhem I,Rodrigues E

更新日期：2015-01-01 00:00:00