Abstract：
:The role of matrix metalloproteinase-12 (MMP-12) in the pathogenesis of several inflammatory diseases such as chronic obstructive pulmonary disease, emphysema, and asthma is well established. Several new studies and recent reports from our laboratory and others highlighted the detrimental role of MMP-12 in the pathogenesis of several neurological diseases. In this review, we discuss in detail the pathological role of MMP-12 and the possible underlying molecular mechanisms that contribute to disease pathogenesis in the context of central nervous system diseases such as stroke, spinal cord injury, and multiple sclerosis. The available information on the specific MMP-12 inhibitors used in several preclinical and clinical studies is also reviewed. Based on the reported studies to date, MMP-12 suppression could emerge as a promising therapeutic target for several CNS diseases that were discussed in this review.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Chelluboina B,Nalamolu KR,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KKdoi
10.1007/s12035-017-0418-5subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1405-1409issue
2eissn
0893-7648issn
1559-1182pii
10.1007/s12035-017-0418-5journal_volume
55pub_type
杂志文章,评审abstract：:In the developing mammalian, neocortex gap junctions represent a transient, metabolic, and electrical communication system. These gap junctions may play a crucial role during the formation and refinement of neocortical synaptic circuitries. This article focuses on two major points. First, the influence of gap junction...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02755590
更新日期：1996-06-01 00:00:00
abstract：:There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consum...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-0969-0
更新日期：2018-12-01 00:00:00
abstract：:Cytosolic phospholipase A2 (cPLA2) mediates oligomeric amyloid-β peptide (oAβ)-induced oxidative and inflammatory responses in glial cells. Increased activity of cPLA2 has been implicated in the neuropathology of Alzheimer's disease (AD), suggesting that cPLA2 regulation of oAβ-induced microglial activation may play a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1304-5
更新日期：2019-05-01 00:00:00
abstract：:Lafora progressive myoclonus epilepsy (Lafora disease, LD) is a fatal rare autosomal recessive neurodegenerative disorder characterized by the accumulation of insoluble ubiquitinated polyglucosan inclusions in the cytoplasm of neurons, which is most commonly associated with mutations in two genes: EPM2A, encoding the ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9884-4
更新日期：2017-07-01 00:00:00
abstract：:Endozepine has recently been isolated from various steroid-forming organs. The following article explores the role of endozepine in the regulation of steroid synthesis. Steroid hormone synthesis from cholesterol begins in the inner mitochondrial membrane, where cytochrome P450 converts cholesterol to pregnenolone. Sci...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02740835
更新日期：1995-02-01 00:00:00
abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-007-0002-5
更新日期：2007-08-01 00:00:00
abstract：:The melanocortin pathway has been implicated in both metabolism and sexual function. When the melanocortin 4 receptor (MC4R) is knocked out globally, male mice display obesity, low sexual desire, and copulatory difficulties; however, it is unclear whether these phenotypes are interdependent. To elucidate the neuronal ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1514-5
更新日期：2019-09-01 00:00:00
abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved with neurotransmitter release. Wit...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8887-2
更新日期：2015-08-01 00:00:00
abstract：:Alzheimer's disease (AD) is one of the most common forms of dementia among elder people, which is a progressive neurodegenerative disease that results from a chronic loss of cognitive activities. It has been observed that AD is multifactorial, hence diverse pharmacological targets that could be followed for the treatm...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02116-9
更新日期：2021-01-01 00:00:00
abstract：:The effects and mechanism of action of oligodeoxyribonucleotides containing CpG motif (CpG-ODNs) on neuron cells are largely unexamined. Here, we found that CpG-A ODNs but not other types of CpG-ODNs induced neurite retraction and cell apoptosis of rat embryonic neurons in a TLR9-independent manner. These effects of C...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8275-8
更新日期：2012-06-01 00:00:00
abstract：:α-Lipoic acid-plus (LAP), an amine derivative of α-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron. However, the application of LAP in experimental subarachnoid hemorrhage (SAH) is still not well known. This study was designed to evaluate the potential neuroprotection...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8846-y
更新日期：2015-08-01 00:00:00
abstract：:Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01849-6
更新日期：2020-04-01 00:00:00
abstract：:Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in numerous animal species. Although several studies have focused on the morphological fate of neurons dying acutely by GA-induced developmental neuroapoptos...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9246-7
更新日期：2015-10-01 00:00:00
abstract：:Rare coding variants in the phospholipase D3 (PLD3) gene, also known as HU-K4, have recently been identified to increase the risk for late-onset Alzheimer's disease (LOAD) by the whole exome sequencing (WES) in 14 large LOAD families and follow-up analyses of the candidate variants in several large independent LOAD ca...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8779-5
更新日期：2015-04-01 00:00:00
abstract：:Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0695-z
更新日期：2018-06-01 00:00:00
abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease that leads to neuronal cell loss. Cyclic AMP and its analogs are well known to decrease inflammation and apoptosis. In the present study, we examined the effects of bucladesine, a cell-permeable analogue of cyclic adenosine monophosphate (cAMP), on myeli...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8857-8
更新日期：2015-08-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was re...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0322-4
更新日期：2017-12-01 00:00:00
abstract：:One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the "second brain" and be responsible for neurodegenerative disorders ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-1188-4
更新日期：2019-03-01 00:00:00
abstract：:L-DOPA is the main pharmacological therapy for Parkinson's disease. However, long-term exposure to L-DOPA induces involuntary movements termed dyskinesia. Clinical trials show that dyskinesia is attenuated by metabotropic glutamate receptor type 5 (mGluR5) antagonists. Further, the onset of dyskinesia is delayed by ni...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1356-6
更新日期：2019-06-01 00:00:00
abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9465-y
更新日期：2016-10-01 00:00:00
abstract：:Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis (ALS), while wild-type TDP-43 is a pathological hallmark of patients with sporadic ALS and frontotemporal lobar degeneration (FTLD). Various in vitro and in vivo studies have also demonstrated toxicity ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8427-5
更新日期：2013-08-01 00:00:00
abstract：:Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0177-8
更新日期：2017-10-01 00:00:00
abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0280-x
更新日期：2017-12-01 00:00:00
abstract：:The development of in vitro amplification systems allows detecting femtomolar amounts of prion protein scrapie (PrP(Sc)) in human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects of prion disease type, codon 129 genotype, PrP(Sc) type, and other disease-related factors on the real-time quak...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8709-6
更新日期：2015-02-01 00:00:00
abstract：:The neurotoxicity of levodopa (L-DOPA) on neural stem cells (NSCs) and treatment strategies to protect NSCs from this neurotoxicity remain to be elucidated. Recently, an active form of vitamin D3 has been reported to display neuroprotective properties. Therefore, we investigated the protective effect of 1,25-dyhydroxy...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8835-1
更新日期：2015-04-01 00:00:00
abstract：:Metals perform important functions in the normal physiological system, and alterations in their levels may lead to a number of diseases. Aluminium (Al) has been implicated as a major risk factor, which is linked to several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. On the other h...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8643-7
更新日期：2014-10-01 00:00:00
abstract：:Hypertension is one of the co-morbid conditions for stroke and profoundly increases its incidence. Angiotensin II (AngII) is shown to be at the center stage in driving the renin angiotensin system via activation of angiotensin 1 receptor (AT1R). This makes the AT1R gene one of the candidates whose differential regulat...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9109-2
更新日期：2016-04-01 00:00:00
abstract：:(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9924-0
更新日期：2017-07-01 00:00:00
abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01774-8
更新日期：2020-02-01 00:00:00
abstract：:Impaired neurogenesis has been associated with several brain disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). The role of peroxiredoxin 6 (PRDX6) in neurodegenerative diseases is very controversial. To demonstrate the role of PRDX6 in neurogenesis, we compared the neurogenesis ability of PRDX6...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1287-2
更新日期：2019-05-01 00:00:00
