PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal.

abstract：:The transition from occasional to escalated psychostimulant use is accelerated by prior drug exposure. These behavioral observations may be related to long-lasting transcriptional and/or epigenetic changes induced by the drug pre-exposure. Herein, we investigated if a single methamphetamine (METH) injection would enha...

journal_title：Molecular neurobiology

authors： Jayanthi S,Torres OV,Ladenheim B,Cadet JL

更新日期：2020-03-01 00:00:00

abstract：:Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in autophagy/m...

journal_title：Molecular neurobiology

authors： Feng J,Chen X,Guan B,Li C,Qiu J,Shen J

更新日期：2018-08-01 00:00:00

abstract：:Three early signals of asymmetry have been described to occur in a single neurite of neurons at stage 2 of differentiation (before polarization) and shown to be essential for neuronal polarization: (i) accumulation of stable microtubules, (ii) enrichment of the plasma membrane with activatable IGF-1r, and (iii) polari...

journal_title：Molecular neurobiology

authors： Oksdath M,Guil AFN,Grassi D,Sosa LJ,Quiroga S

更新日期：2017-10-01 00:00:00

abstract：:Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...

journal_title：Molecular neurobiology

authors： Malenka RC

更新日期：1991-01-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in st...

journal_title：Molecular neurobiology

authors： Jiang S,Deng C,Lv J,Fan C,Hu W,Di S,Yan X,Ma Z,Liang Z,Yang Y

更新日期：2017-03-01 00:00:00

abstract：:In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...

journal_title：Molecular neurobiology

authors： Luo H,Cao L,Liang X,Du A,Peng T,Li H

更新日期：2018-10-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered as an intermediate zone between normal aging and dementia. The most prominent feature of MCI is an isolated mild decline in memory, whereas other cognitive functions remain intact. The symptoms of vascular cognitive impairment (VCI) range from MCI to dementia, and an anima...

journal_title：Molecular neurobiology

authors： Yang EJ,Cai M,Lee JH

更新日期：2016-12-01 00:00:00

abstract：:Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions. Although phosphat...

journal_title：Molecular neurobiology

authors： Paoletti L,Domizi P,Marcucci H,Montaner A,Krapf D,Salvador G,Banchio C

更新日期：2016-11-01 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK-3β) is a key element to phosphorylate tau and form neurofibrillary tangles (NFTs) found in tauopathies including Alzheimer's disease (AD). A current topic for AD therapy is focused upon how to prevent tau phosphorylation. In the present study, PKCε activated Akt and inactivated GSK-3β ...

journal_title：Molecular neurobiology

authors： Kanno T,Tsuchiya A,Tanaka A,Nishizaki T

更新日期：2016-09-01 00:00:00

abstract：:Epidemiological, population-based case-control, and experimental studies at the molecular, cellular, and organism levels revealed that exposure to various environmental agents, including a number of structurally different agrochemicals, may contribute to the pathogenesis of Parkinson's disease (PD) and several other n...

journal_title：Molecular neurobiology

authors： Silva BA,Breydo L,Fink AL,Uversky VN

更新日期：2013-04-01 00:00:00

abstract：:Mammalian brain contains high densities of angiotensin II (Ang II) type 1 (AT1) receptors, localized mainly to specific nuclei within the hypothalamus and brainstem regions. Neuronal AT1 receptors within these areas mediate the stimulatory actions of central Ang II on blood pressure, water and sodium intake, and vasop...

journal_title：Molecular neurobiology

authors： Richards EM,Raizada MK,Gelband CH,Sumners C

更新日期：1999-02-01 00:00:00

abstract：:Huntington's disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal ganglia nuclei. Despite the pathological importance of the striatal degenera...

journal_title：Molecular neurobiology

authors： Kim D,Jeon J,Cheong E,Kim DJ,Ryu H,Seo H,Kim YK

更新日期：2016-05-01 00:00:00

abstract：:Motilin is a 22-amino-acid gastrointestinal polypeptide that was first isolated from the porcine intestine. We identified that motilin receptor is highly expressed in GABAergic interneurons in the basolateral nucleus (BLA) of the amygdala, the structure of which is closely involved in assigning stress disorder and anx...

journal_title：Molecular neurobiology

authors： Feng B,Liu JC,Zhang J,Ozaki K,Guo YY,Yi DH,Li XQ,Zhao MG

更新日期：2013-06-01 00:00:00

abstract：:Tourette syndrome (TS) is a childhood-onset neurological disorder. To date, accurate TS diagnosis remains challenging due to its varied clinical expressions and dependency on qualitative description of symptoms. Therefore, identifying accurate and objective neuroimaging biomarkers may help improve early TS diagnosis. ...

journal_title：Molecular neurobiology

authors： Wen H,Liu Y,Rekik I,Wang S,Chen Z,Zhang J,Zhang Y,Peng Y,He H

更新日期：2018-04-01 00:00:00

abstract：:The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...

journal_title：Molecular neurobiology

authors： Cigliano L,Spagnuolo MS,Crescenzo R,Cancelliere R,Iannotta L,Mazzoli A,Liverini G,Iossa S

更新日期：2018-04-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Lafora progressive myoclonus epilepsy (Lafora disease, LD) is a fatal rare autosomal recessive neurodegenerative disorder characterized by the accumulation of insoluble ubiquitinated polyglucosan inclusions in the cytoplasm of neurons, which is most commonly associated with mutations in two genes: EPM2A, encoding the ...

journal_title：Molecular neurobiology

authors： López-González I,Viana R,Sanz P,Ferrer I

更新日期：2017-07-01 00:00:00

abstract：:Abnormal hippocampal neurogenesis is a prominent feature of temporal lobe epilepsy (TLE) models, which is thought to contribute to abnormal brain activity. Stromal cell-derived factor-1 (SDF-1) and its specific receptor CXCR4 play important roles in adult neurogenesis. We investigated whether treatment with the CXCR4 ...

journal_title：Molecular neurobiology

authors： Song C,Xu W,Zhang X,Wang S,Zhu G,Xiao T,Zhao M,Zhao C

更新日期：2016-04-01 00:00:00

abstract：:α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in Parkinson's disease (PD). The aggregation of α-synuclein is believed to be a critical event in the disease process. α-Synuclein is characterized by a remarkable conformational plasticity, adopting different conforma...

journal_title：Molecular neurobiology

authors： Berrocal R,Vasquez V,Rao Krs S,Gadad BS,Rao KS

更新日期：2015-01-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) exhibits neuropathological and immunological dysfunctions similar to those found in multiple sclerosis (MS) and has been used as an animal model of MS. Inflammatory infiltrates and oxidative stress have been linked to the development of both diseases. ...

journal_title：Molecular neurobiology

authors： Perianes-Cachero A,Lobo MVT,Hernández-Pinto AM,Busto R,Lasunción-Ripa MA,Arilla-Ferreiro E,Puebla-Jiménez L

更新日期：2020-02-01 00:00:00

abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

journal_title：Molecular neurobiology

authors： Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

更新日期：2020-11-01 00:00:00

abstract：:Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effect...

journal_title：Molecular neurobiology

authors： Li C,Zhou C,Li R

更新日期：2016-08-01 00:00:00

abstract：:Heat shock proteins (Hsps) are highly conserved proteins that are induced in response to various physiological and environmental stressors. HspB1 (Hsp27) is a prominent member of the small Hsps family and is strongly induced during the stress response. Notably, HspB1 has powerful neuroprotective effects, increasing th...

journal_title：Molecular neurobiology

authors： O'Reilly AM,Currie RW,Clarke DB

更新日期：2010-10-01 00:00:00

abstract：:Quite a number of studies have examined the effects of fish oil supplementation on cognitive performance in different transgenic animal models of Alzheimer's disease (AD). However, inconsistent and controversial outcomes have been derived from these experiments. In order to investigate whether the beneficial effect of...

journal_title：Molecular neurobiology

authors： Dong S,Huang X,Zhen J,Van Halm-Lutterodt N,Wang J,Zhou C,Yuan L

更新日期：2018-12-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circR...

journal_title：Molecular neurobiology

authors： Gasparini S,Del Vecchio G,Gioiosa S,Flati T,Castrignano T,Legnini I,Licursi V,Ricceri L,Scattoni ML,Rinaldi A,Presutti C,Mannironi C

更新日期：2020-05-01 00:00:00

abstract：:Tissue acidosis is a common feature in many pathological conditions. Activation of acid-sensing ion channel 1a (ASIC1a) plays a key role in acidosis-mediated neurotoxicity. Protein kinase C (PKC) activity has been proved to be associated with many physiological processes and pathological conditions; however, whether P...

journal_title：Molecular neurobiology

authors： Zhang L,Leng TD,Yang T,Li J,Xiong ZG

更新日期：2020-11-01 00:00:00

abstract：:Disturbance of neuregulin-1β/ErbB4 signaling is considered to be associated with brain ischemia, but the mechanisms of this disruption are largely unknown. In the present study, we provide evidence that degradation of ErbB4 is involved in neuronal cell death in response to ischemia. Our data showed that the applicatio...

journal_title：Molecular neurobiology

authors： Lu YM,Gao YP,Tao RR,Liao MH,Huang JY,Wu G,Han F,Li XM

更新日期：2016-05-01 00:00:00

abstract：:A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...

journal_title：Molecular neurobiology

authors： Zhang G,Xia F,Zhang Y,Zhang X,Cao Y,Wang L,Liu X,Zhao G,Shi M

更新日期：2016-05-01 00:00:00

abstract：:Accumulating evidences indicate that endogenous modulators of excitatory synapses in the mammalian brain are potential targets for treating neuropsychiatric disorders. Indeed, glutamatergic and adenosinergic neurotransmissions were recently highlighted as potential targets for developing innovative anxiolytic drugs. A...

journal_title：Molecular neurobiology

authors： Almeida RF,Comasseto DD,Ramos DB,Hansel G,Zimmer ER,Loureiro SO,Ganzella M,Souza DO

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have shown that excessive alcohol drinking is associated with chronic pain development; however, the molecular mechanism underlying this association is poorly understood. In this study, we investigated the effect of chronic alcohol consumption on plantar incision-induced postsurgical pain. We observed...

journal_title：Molecular neurobiology

authors： Liu S,Zhao Z,Guo Y,Shu H,Li C,Tang Y,Xing Y,Tao F

更新日期：2018-05-01 00:00:00