Oxidative Stress and Lymphocyte Alterations in Chronic Relapsing Experimental Allergic Encephalomyelitis in the Rat Hippocampus and Protective Effects of an Ethanolamine Phosphate Salt.

abstract：:A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (AβO) and endogenously liberated Aβ peptides on transcription of genes for...

journal_title：Molecular neurobiology

authors： Cieślik M,Czapski GA,Wójtowicz S,Wieczorek I,Wencel PL,Strosznajder RP,Jaber V,Lukiw WJ,Strosznajder JB

更新日期：2020-03-01 00:00:00

abstract：:Dodecafluoropentane emulsion (DDFPe) in 250 nm nanodroplets seems to swell modestly to accept and carry large amounts of oxygen in the body at >29 °C. Small particle size allows oxygen delivery even into hypoxic tissue unreachable by erythrocytes. Using permanent cerebral embolic occlusion in rabbits, we assessed DDFP...

journal_title：Molecular neurobiology

authors： Woods SD,Skinner RD,Ricca AM,Brown AT,Lowery JD,Borrelli MJ,Lay JO,Culp WC

更新日期：2013-10-01 00:00:00

abstract：:A great deal of attention has been paid to neuroprotective therapies for cerebral ischemic stroke. Our two recent clinical trials showed that ginsenoside Rd (Rd), a kind of monomeric compound extracted from Chinese herbs, Panax ginseng and Panax notoginseng, was safe and efficacious for the treatment of ischemic strok...

journal_title：Molecular neurobiology

authors： Zhang G,Xia F,Zhang Y,Zhang X,Cao Y,Wang L,Liu X,Zhao G,Shi M

更新日期：2016-05-01 00:00:00

abstract：:After its discovery in 2000, the notion grew that neuroglobin, a neuronal specific heme protein, is involved in cytoprotection. To date, neuroglobin levels have been positively correlated with a beneficial outcome in a plethora of neurotoxic insults, e.g., ischemic and traumatic brain injuries and Alzheimer's disease....

journal_title：Molecular neurobiology

authors： Van Acker ZP,Luyckx E,Dewilde S

更新日期：2019-03-01 00:00:00

abstract：:Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular aspects that precede or accompany the deposit of β-amyloid in senile plaques attract attention, such as calcium dysregulation and neuroinflammation. It has been suggested that the Ca2+/calmodulin-dependent protein phosphatase, calcin...

journal_title：Molecular neurobiology

authors： Dos Santos JPA,Vizuete AF,Gonçalves CA

更新日期：2020-01-01 00:00:00

abstract：:The 22q11.2 deletion has been identified as a risk factor for multiple neurodevelopmental disorders. Behavioral and cognitive impairments are common among carriers of the 22q11.2 deletion. Parvalbumin expressing (PV+) interneurons provide perisomatic inhibition of excitatory neuronal circuits through GABAA receptors, ...

journal_title：Molecular neurobiology

authors： Al-Absi AR,Qvist P,Okujeni S,Khan AR,Glerup S,Sanchez C,Nyengaard JR

更新日期：2020-12-01 00:00:00

abstract：:The LIM domain is a cysteine-rich zinc-finger motif found in a large family of proteins. In LIM-homeodomain (LIM-hd) transcription factors and LIM-only (LMO) factors, the LIM domains are responsible for key interactions with co-activators, co-repressors, competitors, and other transcription factors, and are therefore ...

journal_title：Molecular neurobiology

authors： Rétaux S,Bachy I

更新日期：2002-10-01 00:00:00

abstract：:The neuroprotective potential of 3,3'-diindolylmethane (DIM), which is a selective aryl hydrocarbon receptor modulator, has recently been shown in cellular and animal models of Parkinson's disease and lipopolysaccharide-induced inflammation. However, there are no data concerning the protective capacity and mechanisms ...

journal_title：Molecular neurobiology

authors： Rzemieniec J,Litwa E,Wnuk A,Lason W,Krzeptowski W,Kajta M

更新日期：2016-10-01 00:00:00

abstract：:Neurons are able to adjust the sensitivity of receptor-mediated processes according to the level of receptor activation. Extrapolating from our knowledge of other cellular proteins, regulation of receptor mRNA availability would provide a highly economical means of achieving this objective. Epidermal growth factor is ...

journal_title：Molecular neurobiology

authors： Morris BJ

更新日期：1993-10-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the appearance of motor symptoms many years after the onset of neurodegeneration, which explains low efficiency of therapy. Therefore, one of the priorities in neurology is to develop an early diagnosis and preventive treatment of PD, based on knowledge of molecular mechani...

journal_title：Molecular neurobiology

authors： Mingazov ER,Khakimova GR,Kozina EA,Medvedev AE,Buneeva OA,Bazyan AS,Ugrumov MV

更新日期：2018-04-01 00:00:00

abstract：:Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxi...

journal_title：Molecular neurobiology

authors： Kupershmidt L,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2012-08-01 00:00:00

abstract：:The striatum is divided into two compartments, the striosomes and extrastriosomal matrix, which differ in several cytochemical markers, input-output connections, and time of neurogenesis. Since it is thought that limbic, reward-related information and executive aspects of behavioral information may be differentially p...

journal_title：Molecular neurobiology

authors： Miura M,Masuda M,Aosaki T

更新日期：2008-04-01 00:00:00

abstract：:Regulatory mechanisms of the expression of interleukin-10 (IL-10) in brain inflammatory conditions remain elusive. To address this issue, we used multiple primary brain cell cultures to study the expression of IL-10 in lipopolysaccharide (LPS)-elicited inflammatory conditions. In neuron-glia cultures, LPS triggered we...

journal_title：Molecular neurobiology

authors： Chu CH,Chen SH,Wang Q,Langenbach R,Li H,Zeldin D,Chen SL,Wang S,Gao H,Lu RB,Hong JS

更新日期：2015-08-01 00:00:00

abstract：:People suffering from Huntington's disease (HD) present cognitive deficits. Hippocampal dysfunction has been involved in the HD learning and memory impairment, but proteins leading this dysregulation are not fully characterized. Here, we studied the contribution of the family of transcription factors myocyte enhancer ...

journal_title：Molecular neurobiology

authors： Vidal-Sancho L,Fernández-García S,Solés-Tarrés I,Alberch J,Xifró X

更新日期：2020-11-01 00:00:00

abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...

journal_title：Molecular neurobiology

authors： Marcello E,Musardo S,Vandermeulen L,Pelucchi S,Gardoni F,Santo N,Antonucci F,Di Luca M

更新日期：2019-10-01 00:00:00

abstract：:PCDH19 encodes for protocadherin-19 (PCDH19), a cell-adhesion molecule of the cadherin superfamily preferentially expressed in the brain. PCDH19 mutations cause a neurodevelopmental syndrome named epileptic encephalopathy, early infantile, 9 (EIEE9) characterized by seizures associated with cognitive and behavioral de...

journal_title：Molecular neurobiology

authors： Serratto GM,Pizzi E,Murru L,Mazzoleni S,Pelucchi S,Marcello E,Mazzanti M,Passafaro M,Bassani S

更新日期：2020-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was re...

journal_title：Molecular neurobiology

authors： Heitzer M,Kaiser S,Kanagaratnam M,Zendedel A,Hartmann P,Beyer C,Johann S

更新日期：2017-12-01 00:00:00

abstract：:Germline and somatic mutations in key genes of the mammalian target of rapamycin (mTOR) pathway have been identified in seizure-associated disorders. mTOR mutations lead to aberrant activation of mTOR signaling, and, although affected neurons are critical for epileptogenesis, the role of mTOR activation in glial cells...

journal_title：Molecular neurobiology

authors： Wang X,Sha L,Sun N,Shen Y,Xu Q

更新日期：2017-01-01 00:00:00

abstract：:The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that helps regulate inflammatory pain sensation and nociception and the development of inflammatory diseases. However, the potential role of the TRPA1 channel and the underlying mechanism in brain functions are not fully resol...

journal_title：Molecular neurobiology

authors： Lee KI,Lin HC,Lee HT,Tsai FC,Lee TS

更新日期：2017-07-01 00:00:00

abstract：:Focal cortical dysplasia (FCD) is a major cause for drug-resistant epilepsies. The molecular and cellular mechanisms of epileptogenesis in FCD are still poorly understood. Some studies have suggested that deficiencies of γ-aminobutyric acid (GABA) system may play an important role in type II FCD, but it remains contro...

journal_title：Molecular neurobiology

authors： Zhong S,Zhao Z,Xie W,Cai Y,Zhang Y,Ding J,Wang X

更新日期：2021-01-01 00:00:00

abstract：:Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-month-old male tau kn...

journal_title：Molecular neurobiology

authors： Hull C,Dekeryte R,Koss DJ,Crouch B,Buchanan H,Delibegovic M,Platt B

更新日期：2020-01-01 00:00:00

abstract：:Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintain...

journal_title：Molecular neurobiology

authors： Zhang N,Yu X,Xie J,Xu H

更新日期：2021-01-28 00:00:00

abstract：:Accumulating evidence demonstrated that GABAergic dysfunction contributes to the pathogenesis of Alzheimer's disease (AD). The GABA aminotransferase (ABAT) gene encodes a mitochondrial GABA transaminase and plays key roles in the biogenesis and metabolism of gamma-aminobutyric acid (GABA), which is a major inhibitory ...

journal_title：Molecular neurobiology

authors： Zheng Q,Bi R,Xu M,Zhang DF,Tan LW,Lu YP,Yao YG

更新日期：2021-01-06 00:00:00

abstract：:Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research ...

journal_title：Molecular neurobiology

authors： Tibullo D,Giallongo C,Puglisi F,Tomassoni D,Camiolo G,Cristaldi M,Brundo MV,Anfuso CD,Lupo G,Stampone T,Li Volti G,Amenta F,Avola R,Bramanti V

更新日期：2018-04-01 00:00:00

abstract：:Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...

journal_title：Molecular neurobiology

authors： Matthys A,Haegeman G,Van Craenenbroeck K,Vanhoenacker P

更新日期：2011-06-01 00:00:00

abstract：:The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal models of ischaemic str...

journal_title：Molecular neurobiology

authors： Sánchez-Blázquez P,Pozo-Rodrigálvarez A,Merlos M,Garzón J

更新日期：2018-06-01 00:00:00

abstract：:Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate ...

journal_title：Molecular neurobiology

authors： Pasqualetti F,Orlandi P,Simeon V,Cantarella M,Giuliani D,Di Desidero T,Gonnelli A,Delishaj D,Lombardi G,Sechi A,Sanson M,Zagonel V,Paiar F,Danesi R,Guarini S,Bocci G

更新日期：2018-02-01 00:00:00

abstract：:Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor-positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effect...

journal_title：Molecular neurobiology

authors： Li C,Zhou C,Li R

更新日期：2016-08-01 00:00:00

abstract：:γ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer's disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase subunit, presenilin-1 (PS1). Acute treatment o...

journal_title：Molecular neurobiology

authors： Sogorb-Esteve A,García-Ayllón MS,Llansola M,Felipo V,Blennow K,Sáez-Valero J

更新日期：2018-06-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous compound emerging as a possible toxicant during embryonic development. Human embryonic stem cell (hESC) promises a valuable model for evaluating the effects of environmental chemicals on human prenatal development. In our study, 1 μM BPA were applied to hESC-derived embryoid bodies (h...

journal_title：Molecular neurobiology

authors： Huang B,Ning S,Zhang Q,Chen A,Jiang C,Cui Y,Hu J,Li H,Fan G,Qin L,Liu J

更新日期：2017-07-01 00:00:00