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A short history of LIM domains (1993-2002): from protein interaction to degradation.

Abstract：

:The LIM domain is a cysteine-rich zinc-finger motif found in a large family of proteins. In LIM-homeodomain (LIM-hd) transcription factors and LIM-only (LMO) factors, the LIM domains are responsible for key interactions with co-activators, co-repressors, competitors, and other transcription factors, and are therefore of considerable importance for the regulation of associated transcriptional activity. In this review, the authors describe the progressive discoveries of NLI/Ldb/CLIM, LMO and RLIM, and discuss how the field was very recently updated by the finding that LIM-hd transcriptional activity is controlled by regulated degradation of cofactors and LIM-hd themselves.

journal_name

Mol Neurobiol

journal_title

Molecular neurobiology

authors

Rétaux S,Bachy I

doi

10.1385/MN:26:2-3:269

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

269-81

issue

2-3

eissn

0893-7648

issn

1559-1182

pii

MN:26:2-3:269

journal_volume

26

pub_type

杂志文章,评审

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