rTMS Ameliorates PTSD Symptoms in Rats by Enhancing Glutamate Transmission and Synaptic Plasticity in the ACC via the PTEN/Akt Signalling Pathway.

abstract：:Human hGDH2 arose via duplication in the apes and driven by positive selection acquired enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all mammals). To explore the biological advantage provided by the novel enzyme, we studied, by immunohistochemistry (IHC) and immunofluorescen...

journal_title：Molecular neurobiology

authors： Spanaki C,Kotzamani D,Kleopa K,Plaitakis A

更新日期：2016-10-01 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a member of NAD+-dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present study, we observed that ...

journal_title：Molecular neurobiology

authors： Xie XQ,Zhang P,Tian B,Chen XQ

更新日期：2017-11-01 00:00:00

abstract：:Extracellular nucleotides, particularly adenosine 5'-triphosphate (ATP), act as signaling molecules in the inner ear. Roles as neurotransmitters, neuromodulators, and as autocrine or paracrine humoral factors are evident. The diversity of the signaling pathways for nucleotides, which include a variety of ATP-gated ion...

journal_title：Molecular neurobiology

authors： Housley GD

更新日期：1998-02-01 00:00:00

abstract：:The neuronal-specific cholesterol 24S-hydroxylase (CYP46A1) is important for brain cholesterol elimination. Cyp46a1 null mice exhibit severe deficiencies in learning and hippocampal long-term potentiation, suggested to be caused by a decrease in isoprenoid intermediates of the mevalonate pathway. Conversely, transgeni...

journal_title：Molecular neurobiology

authors： Moutinho M,Nunes MJ,Gomes AQ,Gama MJ,Cedazo-Minguez A,Rodrigues CM,Björkhem I,Rodrigues E

更新日期：2015-01-01 00:00:00

abstract：:Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to ...

journal_title：Molecular neurobiology

authors： Geranmayeh MH,Nourazarian A,Avci ÇB,Rahbarghazi R,Farhoudi M

更新日期：2017-12-01 00:00:00

abstract：:Neurons are highly polarized cells displaying an elaborate architectural morphology. The design of their dendritic arborization and the distribution of their synapses contribute importantly to information processing in the brain. The growth and complexity of dendritic arbors are driven by the formation of synapses alo...

journal_title：Molecular neurobiology

authors： Lira M,Arancibia D,Orrego PR,Montenegro-Venegas C,Cruz Y,García J,Leal-Ortiz S,Godoy JA,Gundelfinger ED,Inestrosa NC,Garner CC,Zamorano P,Torres VI

更新日期：2019-07-01 00:00:00

abstract：:Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide association and other genetic studies have implicated at least 500+ genes associated with the occurrence of autism spectrum disorders (ASD) including the human semaphorin 3F (Sema 3F) and neuropilin 2 (NRP2) genes. However, the geneti...

journal_title：Molecular neurobiology

authors： Li Z,Jagadapillai R,Gozal E,Barnes G

更新日期：2019-08-01 00:00:00

abstract：:Long-lasting changes in dendritic spines provide a physical correlate for memory formation and persistence. LIM kinase (LIMK) plays a critical role in orchestrating dendritic actin dynamics during memory processing, since it is the convergent downstream target of both the Rac1/PAK and RhoA/ROCK pathways that in turn i...

journal_title：Molecular neurobiology

authors： Lunardi P,Sachser RM,Sierra RO,Pedraza LK,Medina C,de la Fuente V,Romano A,Quillfeldt JA,de Oliveira Alvares L

更新日期：2018-02-01 00:00:00

abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...

journal_title：Molecular neurobiology

authors： Chiang WC,Kroeger H,Sakami S,Messah C,Yasumura D,Matthes MT,Coppinger JA,Palczewski K,LaVail MM,Lin JH

更新日期：2015-08-01 00:00:00

abstract：:Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...

journal_title：Molecular neurobiology

authors： Islam A,Kagawa Y,Miyazaki H,Shil SK,Umaru BA,Yasumoto Y,Yamamoto Y,Owada Y

更新日期：2019-08-01 00:00:00

abstract：:Although statins, or hydroxymethylglutaryl coenzyme A (HMG-Co A) reductase inhibitors, are generally used to decrease levels of circulating cholesterol, they have also been reported to have neuroprotective effects through various mechanisms. However, recent results have indicated that they may be harmful in patients w...

journal_title：Molecular neurobiology

authors： Lee SH,Choi NY,Yu HJ,Park J,Choi H,Lee KY,Huh YM,Lee YJ,Koh SH

更新日期：2016-01-01 00:00:00

abstract：:Defect in brain microperfusion is increasingly recognized as an antecedent event to Alzheimer's disease (AD) and ischemia. Nevertheless, studies on the role of impaired microperfusion as a pathological trigger to neuroinflammation, Aβ deposition as well as blood-brain barrier (BBB) disruption, and the etiological link...

journal_title：Molecular neurobiology

authors： Amtul Z,Yang J,Nikolova S,Lee TY,Bartha R,Cechetto DF

更新日期：2018-10-01 00:00:00

abstract：:Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor ...

journal_title：Molecular neurobiology

authors： Velasco G,Carracedo A,Blázquez C,Lorente M,Aguado T,Haro A,Sánchez C,Galve-Roperh I,Guzmán M

更新日期：2007-08-01 00:00:00

abstract：:In Alzheimer's disease (AD), excessive amounts of quinolinic acid (QUIN) accumulate within the brain parenchyma and dystrophic neurons. QUIN also regulates glutamate uptake into neurons, which may be due to modulation of Na+-dependent excitatory amino acid transporters (EAATs). To determine the biological relationship...

journal_title：Molecular neurobiology

authors： Braidy N,Alicajic H,Pow D,Smith J,Jugder BE,Brew BJ,Nicolazzo JA,Guillemin GJ

更新日期：2021-01-01 00:00:00

abstract：:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...

journal_title：Molecular neurobiology

authors： Gutiérrez IL,González-Prieto M,García-Bueno B,Caso JR,Feinstein DL,Madrigal JLM

更新日期：2018-10-01 00:00:00

abstract：:After its discovery in 2000, the notion grew that neuroglobin, a neuronal specific heme protein, is involved in cytoprotection. To date, neuroglobin levels have been positively correlated with a beneficial outcome in a plethora of neurotoxic insults, e.g., ischemic and traumatic brain injuries and Alzheimer's disease....

journal_title：Molecular neurobiology

authors： Van Acker ZP,Luyckx E,Dewilde S

更新日期：2019-03-01 00:00:00

abstract：:Resveratrol is a natural compound that mimics the antioxidant and antiaging effects of caloric restriction, mainly mediated through SIRT1, a deacetylase that induces longevity and neuroprotection. We aimed to analyze the effects of resveratrol on the brain status of control non-transgenic (NoTg) and AD transgenic (3xT...

journal_title：Molecular neurobiology

authors： Corpas R,Griñán-Ferré C,Rodríguez-Farré E,Pallàs M,Sanfeliu C

更新日期：2019-02-01 00:00:00

abstract：:The identification of causative mutations in the (pro)granulin gene (GRN) has been a major breakthrough in the research on frontotemporal dementia (FTD). So far, all FTD-associated GRN mutations are leading to neurodegeneration through a "loss-of-function" mechanism, encouraging researchers to develop a growing number...

journal_title：Molecular neurobiology

authors： Kleinberger G,Capell A,Haass C,Van Broeckhoven C

更新日期：2013-02-01 00:00:00

abstract：:Long-term potentiation (LTP), a long-lasting, activity-dependent increase in the strength of synaptic transmission, is one of the most intensively studied forms of synaptic plasticity in the mammalian brain. In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium ...

journal_title：Molecular neurobiology

authors： Malenka RC

更新日期：1991-01-01 00:00:00

abstract：:Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...

journal_title：Molecular neurobiology

authors： Malan-Müller S,Hemmings SM,Seedat S

更新日期：2013-04-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common primary malignant cancer of brain, which is extremely aggressive and carries a dreadful prognosis. Current treatment protocol runs around radiotherapy, surgical resection, and temozolomide with median overall survival of around 12-15 months. Due to its heterogeneity and...

journal_title：Molecular neurobiology

authors： Jindal V

更新日期：2018-11-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in st...

journal_title：Molecular neurobiology

authors： Jiang S,Deng C,Lv J,Fan C,Hu W,Di S,Yan X,Ma Z,Liang Z,Yang Y

更新日期：2017-03-01 00:00:00

abstract：:The development of in vitro amplification systems allows detecting femtomolar amounts of prion protein scrapie (PrP(Sc)) in human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects of prion disease type, codon 129 genotype, PrP(Sc) type, and other disease-related factors on the real-time quak...

journal_title：Molecular neurobiology

authors： Cramm M,Schmitz M,Karch A,Zafar S,Varges D,Mitrova E,Schroeder B,Raeber A,Kuhn F,Zerr I

更新日期：2015-02-01 00:00:00

abstract：:Polyglutamine [poly(Q)] disorders are a class of trinucleotide repeat expansion neurodegenerative disorders which are dominantly inherited and progressively acquired with age. This group of disorders entail the characteristic formation of protein aggregates leading to widespread loss of neurons in different regions of...

journal_title：Molecular neurobiology

authors： Raj K,Sarkar S

更新日期：2019-02-01 00:00:00

abstract：:We present new ideas about motor control in the human central nervous system and about pathophysiological mechanisms of Parkinson's disease, and we describe the Posturo-Locomotion-Manual (PLM) method, which is a new technique utilizing optoelectronic camera recording for objective, fully quantitative, and standardized...

journal_title：Molecular neurobiology

authors： Steg G,Johnels B

更新日期：1994-08-01 00:00:00

abstract：:For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...

journal_title：Molecular neurobiology

authors： Leuner B,Shors TJ

更新日期：2004-04-01 00:00:00

abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...

journal_title：Molecular neurobiology

authors： Lu AQ,Barnstable CJ

更新日期：2019-09-01 00:00:00

abstract：:Growing evidence has indicated that iron deposition is one of the key factors leading to neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein composed of 24 subunits of two types, ferritin heavy chain (FTH) and ferritin light chain (FTL), which plays an important role in maintain...

journal_title：Molecular neurobiology

authors： Zhang N,Yu X,Xie J,Xu H

更新日期：2021-01-28 00:00:00

abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...

journal_title：Molecular neurobiology

authors： Ustyugov A,Shevtsova E,Bachurin S

更新日期：2015-10-01 00:00:00

abstract：:Studies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the bra...

journal_title：Molecular neurobiology

authors： Ren M,Li K,Wang D,Guo J,Li J,Yang G,Long X,Shen W,Hu R,Wang X,Zeng K

更新日期：2016-11-01 00:00:00