Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme.

abstract：:People suffering from Huntington's disease (HD) present cognitive deficits. Hippocampal dysfunction has been involved in the HD learning and memory impairment, but proteins leading this dysregulation are not fully characterized. Here, we studied the contribution of the family of transcription factors myocyte enhancer ...

journal_title：Molecular neurobiology

authors： Vidal-Sancho L,Fernández-García S,Solés-Tarrés I,Alberch J,Xifró X

更新日期：2020-11-01 00:00:00

abstract：:The chronic stage multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), remains refractory to current treatments. This refractory nature may be due to the fact that current treatments are primarily immunomodulatory, which prevent further demyelination but lack the capacity...

journal_title：Molecular neurobiology

authors： Li X,Zhang Y,Yan Y,Ciric B,Ma CG,Chin J,Curtis M,Rostami A,Zhang GX

更新日期：2017-08-01 00:00:00

abstract：:Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced quality of life. One factor that significantly contributes to the relevant disease burden of MDD is the heterogeneous treatment response patients experience with cu...

journal_title：Molecular neurobiology

authors： Ignácio ZM,da Silva RS,Plissari ME,Quevedo J,Réus GZ

更新日期：2019-12-01 00:00:00

abstract：:Information processing in neurobiological systems is commonly thought to rely on the assessment of a signal-to-noise ratio as the key mechanism of signal detection; it assumes and requires that both signal and noise are concurrently available. An alternative theory holds that detection proceeds by the system appreciat...

journal_title：Molecular neurobiology

authors： Colpaert FC,Frégnac Y

更新日期：2001-08-01 00:00:00

abstract：:The loss of dopaminergic (DA) neurons in the substantia nigra (SN) is a major feature in the pathology of Parkinson's disease (PD). Using neural stem or progenitor cells (NSC/NPCs), the prospect of replacing the missing or damaged DA neurons is very attractive for PD therapy. However, little is known about the endogen...

journal_title：Molecular neurobiology

authors： Zhou Y,Zhu J,Lv Y,Song C,Ding J,Xiao M,Lu M,Hu G

更新日期：2018-11-01 00:00:00

abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...

journal_title：Molecular neurobiology

authors： Slikker W Jr,Liu F,Rainosek SW,Patterson TA,Sadovova N,Hanig JP,Paule MG,Wang C

更新日期：2015-10-01 00:00:00

abstract：:The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that helps regulate inflammatory pain sensation and nociception and the development of inflammatory diseases. However, the potential role of the TRPA1 channel and the underlying mechanism in brain functions are not fully resol...

journal_title：Molecular neurobiology

authors： Lee KI,Lin HC,Lee HT,Tsai FC,Lee TS

更新日期：2017-07-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal dea...

journal_title：Molecular neurobiology

authors： Wu X,Walker CL,Lu Q,Wu W,Eddelman DB,Parish JM,Xu XM

更新日期：2017-11-01 00:00:00

abstract：:Although the use, and misuse, of methylphenidate is increasing in childhood and adolescence, there is little information about the consequences of this psychostimulant chronic use on brain and behavior during development. The aim of the present study was to investigate hippocampus biochemical, histochemical, and behav...

journal_title：Molecular neurobiology

authors： Schmitz F,Pierozan P,Rodrigues AF,Biasibetti H,Grunevald M,Pettenuzzo LF,Scaini G,Streck EL,Netto CA,Wyse ATS

更新日期：2017-08-01 00:00:00

abstract：:Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in...

journal_title：Molecular neurobiology

authors： Lee ST,Seo Y,Bae JY,Chu K,Kim JW,Choi SH,Kim TM,Kim IH,Park SH,Park CK

更新日期：2018-06-01 00:00:00

abstract：:Enriched environment (EE) protects the retina from adult rats against ischemia/reperfusion (I/R) injury; however, how the components of EE contribute to the recovery after retinal ischemic damage remains unclear. We analyzed the contribution of social, cognitive, and visual stimulation on functional and histological a...

journal_title：Molecular neurobiology

authors： Fleitas MFG,Aranda ML,Diéguez HH,Milne G,Langellotti L,Miranda M,Altschuler F,Dorfman D,Rosenstein RE

更新日期：2020-01-01 00:00:00

abstract：:The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...

journal_title：Molecular neurobiology

authors： Lee MJ,Jang M,Choi J,Lee G,Min HJ,Chung WS,Kim JI,Jee Y,Chae Y,Kim SH,Lee SJ,Cho IH

更新日期：2016-04-01 00:00:00

abstract：:The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved in mediating fast excitatory synaptic transmission. Recent studies in both heterologous expression systems and cultured neurons have shown that the AMPA recept...

journal_title：Molecular neurobiology

authors： Wang JQ,Arora A,Yang L,Parelkar NK,Zhang G,Liu X,Choe ES,Mao L

更新日期：2005-12-01 00:00:00

abstract：:Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...

journal_title：Molecular neurobiology

authors： Prestigio C,Ferrante D,Valente P,Casagrande S,Albanesi E,Yanagawa Y,Benfenati F,Baldelli P

更新日期：2019-09-01 00:00:00

abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...

journal_title：Molecular neurobiology

authors： Fonseca AC,Moreira PI,Oliveira CR,Cardoso SM,Pinton P,Pereira CF

更新日期：2015-04-01 00:00:00

abstract：:Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...

journal_title：Molecular neurobiology

authors： Malan-Müller S,Hemmings SM,Seedat S

更新日期：2013-04-01 00:00:00

abstract：:Recently, deregulated microRNA (miRNA) expression contributes to the development and progression of human glioblastoma. The aim of the present study was to evaluate the level of miR-154 and Wnt5a in glioblastoma tissues and cells. We further investigated the molecular mechanisms of miR-154 and Wnt5a in glioblastoma ce...

journal_title：Molecular neurobiology

authors： Zhao D,Wang R,Fang J,Ji X,Li J,Chen X,Sun G,Wang Z,Liu W,Wang Y,Cheng G,Zhen H,Sun C,Fei Z

更新日期：2017-05-01 00:00:00

abstract：:The original version of this article unfortunately contained mistake in its Funding inforation. ...

journal_title：Molecular neurobiology

authors： Alvarez-Ricartes N,Oliveros-Matus P,Mendoza C,Perez-Urrutia N,Echeverria F,Iarkov A,Barreto GE,Echeverria V

更新日期：2018-10-01 00:00:00

abstract：:Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects o...

journal_title：Molecular neurobiology

authors： Henn L,Zanta NC,Girardi CEN,Suchecki D

更新日期：2020-10-15 00:00:00

abstract：:Endozepine has recently been isolated from various steroid-forming organs. The following article explores the role of endozepine in the regulation of steroid synthesis. Steroid hormone synthesis from cholesterol begins in the inner mitochondrial membrane, where cytochrome P450 converts cholesterol to pregnenolone. Sci...

journal_title：Molecular neurobiology

authors： Hall PF

更新日期：1995-02-01 00:00:00

abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...

journal_title：Molecular neurobiology

authors： Fröhlich C,Zschiebsch K,Gröger V,Paarmann K,Steffen J,Thurm C,Schropp EM,Brüning T,Gellerich F,Radloff M,Schwabe R,Lachmann I,Krohn M,Ibrahim S,Pahnke J

更新日期：2016-09-01 00:00:00

abstract：:Neurotrophic factors are essential for neuronal survival, plasticity, and development and have been implicated in the action mechanism of antidepressants. In this study, we assessed the neurotrophic factor-inducing and neuroprotective properties of antidepressants. In the first part of the study, we found that fluoxet...

journal_title：Molecular neurobiology

authors： Shadfar S,Kim YG,Katila N,Neupane S,Ojha U,Bhurtel S,Srivastav S,Jeong GS,Park PH,Hong JT,Choi DY

更新日期：2018-01-01 00:00:00

abstract：:Maternal hypothyroxinemia can induce neurodevelopmental impairments in the developing fetus. We here review recent studies on the epidemiology and molecular mechanisms associated with this important public health issue. In 2011, the American Thyroid Association defined maternal hypothyroxinemia as low serum free thyro...

journal_title：Molecular neurobiology

authors： Min H,Dong J,Wang Y,Wang Y,Teng W,Xi Q,Chen J

更新日期：2016-04-01 00:00:00

abstract：:Accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in several neurodegenerative disorders. Therefore, development of methods for microglial inhibition is considered an important strategy in the search for neuroprotect...

journal_title：Molecular neurobiology

authors： Lu DY,Huang BR,Yeh WL,Lin HY,Huang SS,Liu YS,Kuo YH

更新日期：2013-12-01 00:00:00

abstract：:Neuronal plasticity can be defined as adaptive changes in structure and function of the nervous system, an obvious example of which is the capacity to remember and learn. Long-term potentiation and long-term depression are the experimental models of memory in the central nervous system (CNS), and have been frequently ...

journal_title：Molecular neurobiology

authors： Tokuda M,Hatase O

更新日期：1998-01-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...

journal_title：Molecular neurobiology

authors： Ettcheto M,Cano A,Manzine PR,Busquets O,Verdaguer E,Castro-Torres RD,García ML,Beas-Zarate C,Olloquequi J,Auladell C,Folch J,Camins A

更新日期：2020-04-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental cha...

journal_title：Molecular neurobiology

authors： Odorcyk FK,Ribeiro RT,Roginski AC,Duran-Carabali LE,Couto-Pereira NS,Dalmaz C,Wajner M,Netto CA

更新日期：2021-01-08 00:00:00

abstract：:Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal ...

journal_title：Molecular neurobiology

authors： Lima LCF,Saliba SW,Andrade JMO,Cunha ML,Cassini-Vieira P,Feltenberger JD,Barcelos LS,Guimarães ALS,de-Paula AMB,de Oliveira ACP,Santos SHS

更新日期：2017-07-01 00:00:00

abstract：:Mitochondria are widely recognized as fundamental organelles for cellular physiology and constitute the main energy source for different cellular processes. The location, morphology, and interactions of mitochondria with other organelles, such as the endoplasmic reticulum (ER), have emerged as critical events capable ...

journal_title：Molecular neurobiology

authors： Godoy JA,Valdivieso AG,Inestrosa NC

更新日期：2018-12-01 00:00:00