Abstract：
:The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved in mediating fast excitatory synaptic transmission. Recent studies in both heterologous expression systems and cultured neurons have shown that the AMPA receptor can be phosphorylated on their subunits (GluR1, GluR2, and GluR4). All phosphorylation sites reside at serine, threonine, or tyrosine on the intracellular C-terminal domain. Several key protein kinases, such as protein kinase A, protein kinase C, Ca2+/calmodulin-dependent protein kinase II, and tyrosine kinases (Trks; receptor or nonreceptor family Trks) are involved in the site-specific regulation of the AMPA receptor phosphorylation. Other glutamate receptors (N-methyl-d-aspartate receptors and metabotropic glutamate receptors) also regulate AMPA receptors through a protein phosphorylation mechanism. Emerging evidence shows that as a rapid and short-term mechanism, the dynamic protein phosphorylation directly modulates the electrophysiological, morphological (externalization and internalization trafficking and clustering), and biochemical (synthesis and subunit composition) properties of the AMPA receptor, as well as protein-protein interactions between the AMPA receptor subunits and various intracellular interacting proteins. These modulations underlie the major molecular mechanisms that ultimately affect many forms of synaptic plasticity.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wang JQ,Arora A,Yang L,Parelkar NK,Zhang G,Liu X,Choe ES,Mao Ldoi
10.1385/MN:32:3:237subject
Has Abstractpub_date
2005-12-01 00:00:00pages
237-49issue
3eissn
0893-7648issn
1559-1182pii
MN:32:3:237journal_volume
32pub_type
杂志文章,评审abstract：:The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析,评审
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更新日期：2016-05-01 00:00:00
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pub_type： 杂志文章,收录出版
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Molecular neurobiology
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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