LSD1 is Required for Hair Cell Regeneration in Zebrafish.

abstract：:Multiple players are involved in motor and sensory dysfunctions after spinal cord injury (SCI). Therefore, therapeutic approaches targeting these various players in the damage cascade hold considerable promise for the treatment of traumatic spinal cord injury. Soluble epoxide hydrolase (sEH) is an endogenous key enzym...

journal_title：Molecular neurobiology

authors： Chen X,Chen X,Huang X,Qin C,Fang Y,Liu Y,Zhang G,Pan D,Wang W,Xie M

更新日期：2016-04-01 00:00:00

abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...

journal_title：Molecular neurobiology

authors： Murphy M,Bartlett PF

更新日期：1993-07-01 00:00:00

abstract：:The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2...

journal_title：Molecular neurobiology

authors： Du N,Xu D,Hou X,Song X,Liu C,Chen Y,Wang Y,Li X

更新日期：2016-05-01 00:00:00

abstract：:Peripheral nerve injury requires optimal conditions in both macro-environment and microenvironment for promotion of axonal regeneration. However, most repair strategies of traumatic peripheral nerve injury often lead to dissatisfying results in clinical outcome. Though various strategies have been carried out to impro...

journal_title：Molecular neurobiology

authors： Bucan V,Vaslaitis D,Peck CT,Strauß S,Vogt PM,Radtke C

更新日期：2019-03-01 00:00:00

abstract：:GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...

journal_title：Molecular neurobiology

authors： Lu XL,Wang L,Chang SY,Shangguan SF,Wang Z,Wu LH,Zou JZ,Xiao P,Li R,Bao YH,Qiu ZY,Zhang T

更新日期：2016-10-01 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) is among the main causes of mortality and morbidity in newborns. Experimental studies show that the immature rat brain is less susceptible to HI injury, suggesting that changes that occur during the first days of life drastically alter its susceptibility. Among the main developmental cha...

journal_title：Molecular neurobiology

authors： Odorcyk FK,Ribeiro RT,Roginski AC,Duran-Carabali LE,Couto-Pereira NS,Dalmaz C,Wajner M,Netto CA

更新日期：2021-01-08 00:00:00

abstract：:Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the BK channel are enriched at the presynaptic nerve terminal, where CaMKII associates with synaptic vesicles whereas the BK channel colocalizes with voltage-sensitive Ca(2+) channels in the plasma membrane. Mounting evidence suggests that these two proteins p...

journal_title：Molecular neurobiology

authors： Wang ZW

更新日期：2008-10-01 00:00:00

abstract：:The infections of prion agents may cause progressive and fatal neurodegenerative diseases in humans and a serial of animal species. Previous studies have proposed that the levels of nitric oxide (NO) and nitric oxide synthase (NOS) in the brains of some neurodegeneration diseases changed, while S-nitrosylation (SNO) o...

journal_title：Molecular neurobiology

authors： Chen LN,Sun J,Yang XD,Xiao K,Lv Y,Zhang BY,Zhou W,Chen C,Gao C,Shi Q,Dong XP

更新日期：2017-04-01 00:00:00

abstract：:Microglial activation is a pathological feature of many neurodegenerative diseases and the role of cellular lipids in these diseases is mostly unknown. It was known that the special ether lipid plasmalogens (Pls) were reduced in the brain and blood samples of Alzheimer's disease (AD) patients. It has recently been rep...

journal_title：Molecular neurobiology

authors： Ali F,Hossain MS,Sejimo S,Akashi K

更新日期：2019-05-01 00:00:00

abstract：:Previous studies have demonstrated depressive or hibernation-like roles of phenothiazine neuroleptics [combined chlorpromazine and promethazine (C + P)] in brain activity. This ischemic stroke study aimed to establish neuroprotection by reducing oxidative stress and improving brain metabolism with post-ischemic C + P ...

journal_title：Molecular neurobiology

authors： Geng X,Li F,Yip J,Peng C,Elmadhoun O,Shen J,Ji X,Ding Y

更新日期：2017-12-01 00:00:00

abstract：:Atonal genes are basic helix-loop-helix transcription factors that were first identified as regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of vertebrate homologs of atonal genes has shown these transcription factors to play diverse roles in the development of neurons and their...

journal_title：Molecular neurobiology

authors： Cai T,Groves AK

更新日期：2015-12-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the several neurodegenerative diseases where accumulation of aggregated proteins like α-synuclein occurs. Dysfunction in autophagy leading to this protein build-up and subsequent dopaminergic neurodegeneration may be one of the causes of PD. The mechanisms that impair autophagy remai...

journal_title：Molecular neurobiology

authors： Selvakumar GP,Iyer SS,Kempuraj D,Ahmed ME,Thangavel R,Dubova I,Raikwar SP,Zaheer S,Zaheer A

更新日期：2019-06-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (AChRs) are a family of acetylcholine-gated cation channels that form the predominant excitatory neurotransmitter receptors on muscles and nerves in the peripheral nervous system. AChRs are also expressed on neurons in lower amounts throughout the central nervous system. AChRs are eve...

journal_title：Molecular neurobiology

authors： Lindstrom J

更新日期：1997-10-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible for the motor and non-motor symptoms in this disease. The main drug prescribed for Parkinsonian patients is L-dopa, which can be converted to dopamin...

journal_title：Molecular neurobiology

authors： Jamebozorgi K,Taghizadeh E,Rostami D,Pormasoumi H,Barreto GE,Hayat SMG,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...

journal_title：Molecular neurobiology

authors： Fonseca AC,Moreira PI,Oliveira CR,Cardoso SM,Pinton P,Pereira CF

更新日期：2015-04-01 00:00:00

abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...

journal_title：Molecular neurobiology

authors： da Encarnação TG,Portugal CC,Nogueira CE,Santiago FN,Socodato R,Paes-de-Carvalho R

更新日期：2018-10-01 00:00:00

abstract：:TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS; the commonest form of motor neuron disease) and in the majority of Tau-negative frontotemporal lobar degeneration (FTLD). There is currently no biochemical test or marker of disease activity for ALS or FTLD, and the clinical d...

journal_title：Molecular neurobiology

authors： Feneberg E,Gray E,Ansorge O,Talbot K,Turner MR

更新日期：2018-10-01 00:00:00

abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...

journal_title：Molecular neurobiology

authors： Shohayeb B,Lim NR,Ho U,Xu Z,Dottori M,Quinn L,Ng DCH

更新日期：2018-07-01 00:00:00

abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...

journal_title：Molecular neurobiology

authors： Doeppner TR,Traut V,Heidenreich A,Kaltwasser B,Bosche B,Bähr M,Hermann DM

更新日期：2017-03-01 00:00:00

abstract：:In neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (ER) stress, leading to neuronal injury and apoptosis. Homocysteine-induced endoplasmic reticulum protein (Herp), an E3 ubiquitin ligase, is an importan...

journal_title：Molecular neurobiology

authors： Luo H,Cao L,Liang X,Du A,Peng T,Li H

更新日期：2018-10-01 00:00:00

abstract：:CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecule. CX3CL1 discloses its bi...

journal_title：Molecular neurobiology

authors： Poniatowski ŁA,Wojdasiewicz P,Krawczyk M,Szukiewicz D,Gasik R,Kubaszewski Ł,Kurkowska-Jastrzębska I

更新日期：2017-04-01 00:00:00

abstract：:The Peruvian plant Lepidium meyenii (Maca) has been shown to possess neuroprotective activity both in vitro and in vivo. Previous studies have also demonstrated the activity of the pentane extract and its macamides, the most representative lipophilic constituents of Maca, in the endocannabinoid system as fatty acid am...

journal_title：Molecular neurobiology

authors： Almukadi H,Wu H,Böhlke M,Kelley CJ,Maher TJ,Pino-Figueroa A

更新日期：2013-10-01 00:00:00

abstract：:In the developing mammalian, neocortex gap junctions represent a transient, metabolic, and electrical communication system. These gap junctions may play a crucial role during the formation and refinement of neocortical synaptic circuitries. This article focuses on two major points. First, the influence of gap junction...

journal_title：Molecular neurobiology

authors： Rörig B,Sutor B

更新日期：1996-06-01 00:00:00

abstract：:The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this proc...

journal_title：Molecular neurobiology

authors： Gutiérrez IL,González-Prieto M,García-Bueno B,Caso JR,Feinstein DL,Madrigal JLM

更新日期：2018-10-01 00:00:00

abstract：:Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...

journal_title：Molecular neurobiology

authors： Montenegro-Burke JR,Woldstad CJ,Fang M,Bade AN,McMillan J,Edagwa B,Boska MD,Gendelman HE,Siuzdak G

更新日期：2019-04-01 00:00:00

abstract：:The complications caused by overweight, obesity and type 2 diabetes are one of the main problems that increase morbidity and mortality in developed countries. Hypothalamic metabolic sensors play an important role in the control of feeding and energy homeostasis. PAS kinase (PASK) is a nutrient sensor proposed as a reg...

journal_title：Molecular neurobiology

authors： Hurtado-Carneiro V,Roncero I,Egger SS,Wenger RH,Blazquez E,Sanz C,Alvarez E

更新日期：2014-10-01 00:00:00

abstract：:Previous studies have provided evidence for axon-to-myelin transfer of intact lipids and lipid precursors for reutilization by myelin enzymes. Several of the lipid constituents of myelin showed significant contralateral/ipsilateral ratios of incorporated radioactivity, indicative of axonal origin, whereas proteins and...

journal_title：Molecular neurobiology

authors： Ledeen RW,Golly F,Haley JE

更新日期：1992-07-01 00:00:00

abstract：:Cannabidiol (CBD), one of the most abundant Cannabis sativa-derived compounds, has been implicated with neuroprotective effect in several human pathologies. Until now, no undesired side effects have been associated with CBD. In this study, we evaluated CBD's neuroprotective effect in terminal differentiation (mature) ...

journal_title：Molecular neurobiology

authors： Schönhofen P,de Medeiros LM,Bristot IJ,Lopes FM,De Bastiani MA,Kapczinski F,Crippa JA,Castro MA,Parsons RB,Klamt F

更新日期：2015-08-01 00:00:00

abstract：:Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3CL1/CX3CR1 axis is associated with the development of ischemic oligodendrocyte and white matter injury. We inve...

journal_title：Molecular neurobiology

authors： Wu XM,Liu Y,Qian ZM,Luo QQ,Ke Y

更新日期：2016-08-01 00:00:00

abstract：:Microwave-induced learning and memory deficits in animal models have been gaining attention in recent years, largely because of increasing public concerns on growing environmental influences. The data from our group and others have showed that the injury of mitochondria, the major source of cellular adenosine triphosp...

journal_title：Molecular neurobiology

authors： Zhao L,Yang YF,Gao YB,Wang SM,Wang LF,Zuo HY,Dong J,Xu XP,Su ZT,Zhou HM,Zhu LL,Peng RY

更新日期：2014-12-01 00:00:00