Abstract：
:Recently, deregulated microRNA (miRNA) expression contributes to the development and progression of human glioblastoma. The aim of the present study was to evaluate the level of miR-154 and Wnt5a in glioblastoma tissues and cells. We further investigated the molecular mechanisms of miR-154 and Wnt5a in glioblastoma cell lines. In the present study, we found that miR-154 expression was downregulated in glioblastoma tissues and U87, U251, and A172 cells (all p < 0.001). By contrast, Wnt5a was upregulated. Furthermore, we found that overexpression of miR-154 suppressed cell migration and invasion of U87 and U251 cells. Mechanically, overexpression of miR-154 inhibited epithelial-to-mesenchymal transition (EMT) of U87 and U251 cells. Importantly, we identified that the 3' untranslated region (3'-UTR) of Wnt5a was a direct target of miR-154. Luciferase reporter assays confirmed that miR-154 binding to the 3'-UTR regions of Wnt5a inhibited the expression of Wnt5a in U87 and U251 cells. At the same time, overexpressed Wnt5a also reversed EMT inhibited by miR-154. In conclusion, this study suggested that high miR-154 expression suppressed glioblastoma cell migration, invasion, and EMT development through targeting Wnt5a, which may be recommended as a therapeutic target for glioblastoma.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Zhao D,Wang R,Fang J,Ji X,Li J,Chen X,Sun G,Wang Z,Liu W,Wang Y,Cheng G,Zhen H,Sun C,Fei Zdoi
10.1007/s12035-016-9867-5subject
Has Abstractpub_date
2017-05-01 00:00:00pages
2823-2830issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9867-5journal_volume
54pub_type
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