Correction to: Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System.

abstract：:Prenatal ethanol exposure can cause extensive apoptotic neurodegeneration throughout the developing central nervous system (CNS), which results in cognitive deficits and memory decline. However, the underlying mechanisms need further study. Single-minded 2 (Sim2), a transcriptional repressor, is reportedly involved in...

journal_title：Molecular neurobiology

authors： Wang X,Yang Z,Sun Y,Zhou H,Chu G,Zhang J,Meng X

更新日期：2015-12-01 00:00:00

abstract：:Brain GABAA/benzodiazepine receptors are highly heterogeneous. This heterogeneity is largely derived from the existence of many pentameric combinations of at least 16 different subunits that are differentially expressed in various brain regions and cell types. This molecular heterogeneity leads to binding differences ...

journal_title：Molecular neurobiology

authors： De Blas AL

更新日期：1996-02-01 00:00:00

abstract：:Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...

journal_title：Molecular neurobiology

authors： Taha AY,Blanchard HC,Cheon Y,Ramadan E,Chen M,Chang L,Rapoport SI

更新日期：2017-08-01 00:00:00

abstract：:Alzheimer's disease is the most common dementia afflicting the elderly in modern society. This disease arises from the neurotoxicity elicited by abnormal aggregates of amyloid-β (Aβ) protein. Such aggregates form through the cleavage of amyloid precursor protein (APP) by β-secretase and the subsequent proteolysis of t...

journal_title：Molecular neurobiology

authors： Lai WB,Wang BJ,Hu MK,Hsu WM,Her GM,Liao YF

更新日期：2014-04-01 00:00:00

abstract：:Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...

journal_title：Molecular neurobiology

authors： Sun F,Johnson SR,Jin K,Uteshev VV

更新日期：2017-04-01 00:00:00

abstract：:Autism spectrum disorders (ASD) comprise a complex of neurodevelopmental disorders caused by a variety of genetic defects and characterized by alterations in social communication and repetitive behavior. Since the mechanisms leading to early neuronal degeneration remain elusive, we chose to examine the properties of N...

journal_title：Molecular neurobiology

authors： Grasselli C,Carbone A,Panelli P,Giambra V,Bossi M,Mazzoccoli G,De Filippis L

更新日期：2020-03-01 00:00:00

abstract：:Olfactory dysfunction is a recognized risk factor for the pathogenesis of Alzheimer's disease (AD), while the mechanisms are still not clear. Here, we applied bilateral olfactory bulbectomy (OBX), an olfactory deprivation surgery to cause permanent anosmia, in human tau-overexpressed mice (htau mice) to investigate ch...

journal_title：Molecular neurobiology

authors： Li K,Liu FF,He CX,Huang HZ,Xie AJ,Hu F,Liu D,Wang JZ,Zhu LQ

更新日期：2016-01-01 00:00:00

abstract：:Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could be associated with the pathophysiology of depression. This study investigated the markers of microglia and astrocyte activation as well as indoleamine 2,3-dioxygenase (IDO) expression in developmental programming after early lif...

journal_title：Molecular neurobiology

authors： Réus GZ,Silva RH,de Moura AB,Presa JF,Abelaira HM,Abatti M,Vieira A,Pescador B,Michels M,Ignácio ZM,Dal-Pizzol F,Quevedo J

更新日期：2019-02-01 00:00:00

abstract：:Myeloperoxidase (MPO) has paradoxically been found to be able to both activate matrix metalloproteinases (MMPs) as well as inhibit MMPs. However, these regulatory effects have not yet been observed in vivo, and it is unclear which pathway is relevant in vivo. We aim to track MPO regulation of MMP activity in living an...

journal_title：Molecular neurobiology

authors： Zhang Y,Dong H,Seeburg DP,Wojtkiewicz GR,Waterman P,Pulli B,Forghani R,Ali M,Iwamoto Y,Swirski FK,Chen JW

更新日期：2019-02-01 00:00:00

abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...

journal_title：Molecular neurobiology

authors： Boghdadi AG,Teo L,Bourne JA

更新日期：2018-03-01 00:00:00

abstract：:Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons of substantia nigra projecting to striatum. The cause of idiopathic PD is obscure, and most cases are sporadic. It is widely accepted that there is a genetic component of the disease, and the earlier the age of onset, the greater the likeli...

journal_title：Molecular neurobiology

authors： Fernandez-Espejo E

更新日期：2004-02-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder accompanied by depletion of dopamine and loss of dopaminergic neurons in the brain that is believed to be responsible for the motor and non-motor symptoms in this disease. The main drug prescribed for Parkinsonian patients is L-dopa, which can be converted to dopamin...

journal_title：Molecular neurobiology

authors： Jamebozorgi K,Taghizadeh E,Rostami D,Pormasoumi H,Barreto GE,Hayat SMG,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy or early childhood. While several hypotheses have been proposed to explain the occurrence of IA, the neurobiological and molecular bases for this accelerated forgetting phenomenon remain elusive. Using hippocampus-depende...

journal_title：Molecular neurobiology

authors： Tsai TC,Huang CC,Hsu KS

更新日期：2019-02-01 00:00:00

abstract：:There is accumulating evidence on the use of N-acetylcysteine (NAC) in the treatment of patients with neuropsychiatric disorders. As a multi-target drug and a glutathione precursor, NAC is a promising molecule in the management of stress-related disorders, for which there is an expanding field of research investigatin...

journal_title：Molecular neurobiology

authors： Mocelin R,Marcon M,D'ambros S,Mattos J,Sachett A,Siebel AM,Herrmann AP,Piato A

更新日期：2019-02-01 00:00:00

abstract：:Topoisomerase I (topo I) is a nuclear enzyme which participates in most DNA transactions. It was shown to be inhibited in depolarized neurons by poly adenosine diphosphate (ADP)-ribosylation of the enzyme protein. We demonstrated previously an age and sex dependent topo I activity and enzyme protein level in the vario...

journal_title：Molecular neurobiology

authors： Zehorai E,Eitan E,Hershfinkel M,Sekler I,Priel E

更新日期：2008-12-01 00:00:00

abstract：:Many neurotransmitters and hormones activate receptors that are known to be coupled to their effectors by GTP-binding regulatory proteins, G proteins. Activation of many of these same receptors elicits arachidonate release and metabolism. During the past few years, novel experimental techniques have revealed that in m...

journal_title：Molecular neurobiology

authors： Burch RM

更新日期：1989-10-01 00:00:00

abstract：:Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism spectrum disorders. The PSD is a thickness, detectable at electronic microscopy, localized at the postsynaptic membrane of glutamatergic syna...

journal_title：Molecular neurobiology

authors： de Bartolomeis A,Latte G,Tomasetti C,Iasevoli F

更新日期：2014-02-01 00:00:00

abstract：:Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...

journal_title：Molecular neurobiology

authors： Hochgräfe K,Mandelkow EM

更新日期：2013-06-01 00:00:00

abstract：:Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate ...

journal_title：Molecular neurobiology

authors： Pasqualetti F,Orlandi P,Simeon V,Cantarella M,Giuliani D,Di Desidero T,Gonnelli A,Delishaj D,Lombardi G,Sechi A,Sanson M,Zagonel V,Paiar F,Danesi R,Guarini S,Bocci G

更新日期：2018-02-01 00:00:00

abstract：:The escalating burden of type 2 diabetes (T2D) and its related complications has become a major public health challenge worldwide. Substantial evidence indicates that T2D is one of the culprits for the high prevalence of Alzheimer's disease (AD) in diabetic subjects. This study aimed to investigate the possible mitoch...

journal_title：Molecular neurobiology

authors： Bhatti JS,Thamarai K,Kandimalla R,Manczak M,Yin X,Kumar S,Vijayan M,Reddy PH

更新日期：2021-02-01 00:00:00

abstract：:The signaling cascades triggered by neurotrophins such as BDNF and by several neurotransmitters and hormones lead to the rapid induction of gene transcription by increasing the intracellular concentration of cAMP and Ca2+. This review examines the mechanisms by which these second messengers control transcriptional ini...

journal_title：Molecular neurobiology

authors： Gabellini N

更新日期：2004-08-01 00:00:00

abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...

journal_title：Molecular neurobiology

authors： Oo TT,Pratchayasakul W,Chattipakorn N,Chattipakorn SC

更新日期：2020-11-01 00:00:00

abstract：:The aim of this work was to study the effect of glucagon-like peptide-2 (GLP-2) on the cyclic guanosine monophosphate (cGMP) signalling pathway and whether insulin or epidermal growth factor (EGF) might modulate the effects of GLP-2. GLP-2 produced a dose-dependent decrease in intracellular sodium nitroprusside-induce...

journal_title：Molecular neurobiology

authors： Velázquez E,Blázquez E,Ruiz-Albusac JM

更新日期：2012-10-01 00:00:00

abstract：:It has been proposed that after nerve injury or tissue inflammation, fractalkine (CX3CL1) released from dorsal root ganglion neurons acts on satellite glial cells (SGCs) through CX3C receptor 1 (CX3CR1) to induce neuroplastic changes. The existence and importance of fractalkine/CX3CR1 signaling in the trigeminal gangl...

journal_title：Molecular neurobiology

authors： Cairns BE,O'Brien M,Dong XD,Gazerani P

更新日期：2017-07-01 00:00:00

abstract：:There is increasing evidence suggesting that one of the most relevant pathophysiological features of Alzheimer's disease (AD) is neuroinflammation, which plays an important role in the production and regulation of AD-related proteins (amyloid beta (Aβ) and Tau) and exacerbates AD pathology. Neuroinflammation can also ...

journal_title：Molecular neurobiology

authors： Magalhães TNC,Weiler M,Teixeira CVL,Hayata T,Moraes AS,Boldrini VO,Dos Santos LM,de Campos BM,de Rezende TJR,Joaquim HPG,Talib LL,Forlenza OV,Cendes F,Balthazar MLF

更新日期：2018-07-01 00:00:00

abstract：:Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD). Recently, we identified and characterized naturally occurring autoantibodies against PrP from IVIG. Although autoantibodies in IVIG blocked PrP fibril formation and ...

journal_title：Molecular neurobiology

authors： Gu H,Kirchhein Y,Zhu T,Zhao G,Peng H,Du E,Liu J,Mastrianni JA,Farlow MR,Dodel R,Du Y

更新日期：2019-04-01 00:00:00

abstract：:Defect in brain microperfusion is increasingly recognized as an antecedent event to Alzheimer's disease (AD) and ischemia. Nevertheless, studies on the role of impaired microperfusion as a pathological trigger to neuroinflammation, Aβ deposition as well as blood-brain barrier (BBB) disruption, and the etiological link...

journal_title：Molecular neurobiology

authors： Amtul Z,Yang J,Nikolova S,Lee TY,Bartha R,Cechetto DF

更新日期：2018-10-01 00:00:00

abstract：:While prion diseases have been described in numerous species, some, including those of the Canidae family, appear to show resistance or reduced susceptibility. A better understanding of the factors underlying prion susceptibility is crucial for the development of effective treatment and control measures. We recently d...

journal_title：Molecular neurobiology

authors： Otero A,Bolea R,Hedman C,Fernández-Borges N,Marín B,López-Pérez Ó,Barrio T,Eraña H,Sánchez-Martín MA,Monzón M,Badiola JJ,Castilla J

更新日期：2018-07-01 00:00:00

abstract：:It is important to understand the molecular mechanisms of barrier disruption in the central nervous system (CNS) of patients with multiple sclerosis (MS). The purpose of the present study was to clarify whether claudin-11 is involved in the disruption of two endothelial barriers (blood-brain barrier (BBB) and blood-sp...

journal_title：Molecular neurobiology

authors： Uchida Y,Sumiya T,Tachikawa M,Yamakawa T,Murata S,Yagi Y,Sato K,Stephan A,Ito K,Ohtsuki S,Couraud PO,Suzuki T,Terasaki T

更新日期：2019-03-01 00:00:00

abstract：:PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellula...

journal_title：Molecular neurobiology

authors： Mincheva-Tasheva S,Nieto Guil AF,Homan CC,Gecz J,Thomas PQ

更新日期：2021-01-07 00:00:00