Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke.

abstract：:Apoptosis plays a crucial role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). However, the exact molecular mechanisms underlying neuronal apoptosis in EBI after SAH have not been fully elucidated. The present study showed that EBI induced significantly neuronal apoptosis activ...

journal_title：Molecular neurobiology

authors： Feng D,Wang B,Ma Y,Shi W,Tao K,Zeng W,Cai Q,Zhang Z,Qin H

更新日期：2016-10-01 00:00:00

abstract：:TREK-1, a two-pore-domain K+ channel, is highly expressed in the central nervous system. Although aberrant expression of TREK-1 is implicated in cognitive impairment, the cellular and functional mechanism underlying this channelopathy is poorly understood. Here we examined TREK-1 contribution to neuronal morphology, e...

journal_title：Molecular neurobiology

authors： Wang W,Kiyoshi CM,Du Y,Taylor AT,Sheehan ER,Wu X,Zhou M

更新日期：2020-03-01 00:00:00

abstract：:Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still u...

journal_title：Molecular neurobiology

authors： de Almeida-Pereira L,Repossi MG,Magalhães CF,Azevedo RF,Corrêa-Velloso JDC,Ulrich H,Ventura ALM,Fragel-Madeira L

更新日期：2018-11-01 00:00:00

abstract：:Maternal deprivation (MD) induces behavioral changes and impacts brain circuits that could be associated with the pathophysiology of depression. This study investigated the markers of microglia and astrocyte activation as well as indoleamine 2,3-dioxygenase (IDO) expression in developmental programming after early lif...

journal_title：Molecular neurobiology

authors： Réus GZ,Silva RH,de Moura AB,Presa JF,Abelaira HM,Abatti M,Vieira A,Pescador B,Michels M,Ignácio ZM,Dal-Pizzol F,Quevedo J

更新日期：2019-02-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a catechin found in green tea, has been previously investigated for its neuroprotective effects in vitro and in vivo. In the present study, we aimed to evaluate its possible beneficial effects in a well-established preclinical mixed model of familial Alzheimer's disease (AD) and type...

journal_title：Molecular neurobiology

authors： Ettcheto M,Cano A,Manzine PR,Busquets O,Verdaguer E,Castro-Torres RD,García ML,Beas-Zarate C,Olloquequi J,Auladell C,Folch J,Camins A

更新日期：2020-04-01 00:00:00

abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...

journal_title：Molecular neurobiology

authors： Souslova T,Mirédin K,Millar AM,Albert PR

更新日期：2017-12-01 00:00:00

abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...

journal_title：Molecular neurobiology

authors： Johnson AM,Sugo E,Barreto D,Hiew CC,Lawson JA,Connolly AM,Somerville E,Hasic E,Bye AM,Cunningham AM

更新日期：2016-10-01 00:00:00

abstract：:Maternal hypothyroxinemia can induce neurodevelopmental impairments in the developing fetus. We here review recent studies on the epidemiology and molecular mechanisms associated with this important public health issue. In 2011, the American Thyroid Association defined maternal hypothyroxinemia as low serum free thyro...

journal_title：Molecular neurobiology

authors： Min H,Dong J,Wang Y,Wang Y,Teng W,Xi Q,Chen J

更新日期：2016-04-01 00:00:00

abstract：:The purpose of this study was to determine whether or not aquaporin-4 (AQP4) gene mutations are related to the pathogenesis of inflammatory demyelinating diseases in the central nervous system. Polymorphisms of AQP4 exons 1-5 were determined by sequencing DNA from 67 patients with central nervous system inflammatory d...

journal_title：Molecular neurobiology

authors： Chu L,Dai Q,Xu Z,He D,Wang H,Wang Q,Zhang Y,Zhu Y,Li Y,Cai G,Slavica K,Allan K

更新日期：2016-07-01 00:00:00

abstract：:Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultim...

journal_title：Molecular neurobiology

authors： Paredes MF,Baraban SC

更新日期：2002-08-01 00:00:00

abstract：:Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced quality of life. One factor that significantly contributes to the relevant disease burden of MDD is the heterogeneous treatment response patients experience with cu...

journal_title：Molecular neurobiology

authors： Ignácio ZM,da Silva RS,Plissari ME,Quevedo J,Réus GZ

更新日期：2019-12-01 00:00:00

abstract：:Interleukin-1 (IL-1) has been implicated in neuroimmune responses and has pleiotropic actions in the brain. Compelling evidence has shown that IL-1 is a major mediator of inflammation and the progression of cell death in response to brain injury and cerebral ischemia. Its expression is strongly increased in these path...

journal_title：Molecular neurobiology

authors： Boutin H,Kimber I,Rothwell NJ,Pinteaux E

更新日期：2003-06-01 00:00:00

abstract：:Stroke is the leading cause of severe disability, and lacunar stroke is related to cognitive decline and hemiparesis. There is no effective treatment for the majority of patients with stroke. Thus, stem cell-based regenerative medicine has drawn a growing body of attention due to the capabilities for trophic factor ex...

journal_title：Molecular neurobiology

authors： Jablonska A,Drela K,Wojcik-Stanaszek L,Janowski M,Zalewska T,Lukomska B

更新日期：2016-11-01 00:00:00

abstract：:The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...

journal_title：Molecular neurobiology

authors： Lee MJ,Jang M,Choi J,Lee G,Min HJ,Chung WS,Kim JI,Jee Y,Chae Y,Kim SH,Lee SJ,Cho IH

更新日期：2016-04-01 00:00:00

abstract：:The induction of synthesis or release of endogenous neurotrophic factors in the brain by low-molecular-weight drugs could be a feasible alternative for the direct administration of neurotrophic factors for the treatment of central nervous system disorders. Recent data suggest that several drugs already in clinical use...

journal_title：Molecular neurobiology

authors： Castrén E

更新日期：2004-06-01 00:00:00

abstract：:A recent genome-wide association study conducted in Caucasians has identified glutaminyl-peptide cyclotransferase (QPCT) gene as a susceptibility gene for schizophrenia, as its common single nucleotide polymorphism (SNP) rs2373000 was significantly associated with the risk of this disease. To date, this finding has no...

journal_title：Molecular neurobiology

authors： Zhang QQ,Jiang T,Gu LZ,Zhu XC,Zhao HD,Gao Q,Zhu HQ,Zhou JS,Zhang YD

更新日期：2016-11-01 00:00:00

abstract：:Beta-amyloid (Aβ) in the brain is a key pathological feature of certain neurodegenerative diseases. Recent studies using graph theory have shown that Aβ brain networks are of pathological significance in Alzheimer's disease (AD). However, the characteristics of Aβ brain networks in Parkinson's disease (PD) are unknown...

journal_title：Molecular neurobiology

authors： Kim J,Ghadery C,Cho SS,Mihaescu A,Christopher L,Valli M,Houle S,Strafella AP

更新日期：2019-11-01 00:00:00

abstract：:Sonic hedgehog (Shh) has been found to regulate the angiogenic growth factor such as VEGF, Ang-1, and Ang-2 during ischemic insults, but the underlying mechanism is not fully understood. In this study, we employed oxygen-glucose deprivation (OGD) in astrocytes to mimic the ischemia in vitro. We found that OGD could in...

journal_title：Molecular neurobiology

authors： Li Y,Xia Y,Wang Y,Mao L,Gao Y,He Q,Huang M,Chen S,Hu B

更新日期：2013-06-01 00:00:00

abstract：:Phospholipase C beta 1 (PLCβ1) expresses in gliomas and cultured glial cells, but its expression is barely detectable in normal glial cells. We analyzed data from Gene Expression Omnibus (GEO-GDSxxx), The Cancer Genome Atlas (TCGA), and the Repository for Molecular Brain Neoplasia Data (REMBRANDT) to explore the poten...

journal_title：Molecular neurobiology

authors： Lu G,Chang JT,Liu Z,Chen Y,Li M,Zhu JJ

更新日期：2016-11-01 00:00:00

abstract：:The glutamate N-methyl-D-aspartate receptor (NMDAR) plays an essential role in the excitotoxic neural damage that follows ischaemic stroke. Because the sigma-1 receptor (σ1R) can regulate NMDAR transmission, exogenous and putative endogenous regulators of σ1R have been investigated using animal models of ischaemic str...

journal_title：Molecular neurobiology

authors： Sánchez-Blázquez P,Pozo-Rodrigálvarez A,Merlos M,Garzón J

更新日期：2018-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent type of dementia in elderly people. There are decreased melatonin levels in the serum of AD patients, and melatonin supplements are able to reverse AD pathology and memory deficits in many animal experiments and clinical trials. However, the underlying mechanism regarding...

journal_title：Molecular neurobiology

authors： Wang X,Wang ZH,Wu YY,Tang H,Tan L,Wang X,Gao XY,Xiong YS,Liu D,Wang JZ,Zhu LQ

更新日期：2013-02-01 00:00:00

abstract：:Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...

journal_title：Molecular neurobiology

authors： Montenegro-Burke JR,Woldstad CJ,Fang M,Bade AN,McMillan J,Edagwa B,Boska MD,Gendelman HE,Siuzdak G

更新日期：2019-04-01 00:00:00

abstract：:Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in unrelated human causative genes, neurological character, and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. The similarities in pathogenesis have been confirmed by findings that ...

journal_title：Molecular neurobiology

authors： Figiel M,Szlachcic WJ,Switonski PM,Gabka A,Krzyzosiak WJ

更新日期：2012-10-01 00:00:00

abstract：:The infections of prion agents may cause progressive and fatal neurodegenerative diseases in humans and a serial of animal species. Previous studies have proposed that the levels of nitric oxide (NO) and nitric oxide synthase (NOS) in the brains of some neurodegeneration diseases changed, while S-nitrosylation (SNO) o...

journal_title：Molecular neurobiology

authors： Chen LN,Sun J,Yang XD,Xiao K,Lv Y,Zhang BY,Zhou W,Chen C,Gao C,Shi Q,Dong XP

更新日期：2017-04-01 00:00:00

abstract：:The use of statins for the prevention or treatment of different neurodegenerative diseases has generated considerable interest albeit with some controversy. Mechanisms of statin-induced neuroprotection are not well understood. Recently, we reported that simvastatin stimulated neuronal gene expression and protein level...

journal_title：Molecular neurobiology

authors： Butterick TA,Igbavboa U,Eckert GP,Sun GY,Weisman GA,Müller WE,Wood WG

更新日期：2010-06-01 00:00:00

abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...

journal_title：Molecular neurobiology

authors： Chiang WC,Kroeger H,Sakami S,Messah C,Yasumura D,Matthes MT,Coppinger JA,Palczewski K,LaVail MM,Lin JH

更新日期：2015-08-01 00:00:00

abstract：:We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3 -/-) mice exhibit abnormal dopamine-related behaviors such as enhanced dopamine D2 receptor antagonist-induced catalepsy behaviors. Here, we report that Fabp3 null mice exhibit cognitive deficits, hyperlocomotion and impaired fear extinct...

journal_title：Molecular neurobiology

authors： Yabuki Y,Takahata I,Matsuo K,Owada Y,Fukunaga K

更新日期：2018-04-01 00:00:00

abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...

journal_title：Molecular neurobiology

authors： da Encarnação TG,Portugal CC,Nogueira CE,Santiago FN,Socodato R,Paes-de-Carvalho R

更新日期：2018-10-01 00:00:00

abstract：:The development of technologies for high-resolution nucleic acid localization in cells and tissues has contributed significantly to our understanding of transcriptional and translational regulation in eukaryotic cells. These methods include nonisotopic in situ hybridization methods for light and electron microscopy, a...

journal_title：Molecular neurobiology

authors： Martone ME,Pollock JA,Ellisman MH

更新日期：1998-12-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...

journal_title：Molecular neurobiology

authors： Kira J

更新日期：1994-04-01 00:00:00